基于码头闸口数据的集卡周转时间短时预测方法

为给车辆调度优化以及集卡预约系统设计提供重要参考,利用所采集的深圳市某港口的码头闸口数据,建立一种基于数据挖掘的集卡周转时间短时预测方法.首先,通过对码头闸口数据进行分析,获取车辆到达时间分布、任务类型、作业方式等集卡作业特征以及集卡在码头内的周转时间;在此基础上,利用循环神经网络并结合训练集数据,建立集卡作业特征与其周转时间之间的映射关系.其次,为减少随机波动对周转时间预测效果的影响,利用小波分解算法对循环神经网络拟合结果的残差进行高频噪声分离,并通过自回归模型拟合过滤后的低频序列.最后,将拟合后的循环神经网络与自回归模型进行结合,建立一种支持集卡周转时间短时预测的组合模型,并利用测试集数据进行有效性验证.结果 表明,相比单一的循环神经网络,该组合模型可以大幅提升预测精度.     

Predictive Event-Triggered Control for Disturbanced Wireless Networked Control Systems

The control and scheduling for wireless networked control system with packet dropout and disturbance are investigated. A prediction based event triggered control is proposed to reduce data transmissions while preserving the robustness against external disturbance. First, a trigger threshold is especially designed to maintain the difference of the estimated and actual states below a proper boundary when system suffers from packet dropout. Then a predictive controller is designed to compensate for packet dropouts by utilizing the packet-based control approach. The sufficient conditions to ensure the closed-loop system being uniformly ultimately bounded are derived, with consequently the controller gain method. Numerical examples illustrate the effectiveness of the proposed approach.     

目标电磁散射的面中心立方体网格FDTD方法

基于面中心立方体(face-centered cube, FCC)网格的空间结构, 由麦克斯韦方程出发, 推导了基于FCC网格的单轴各向异性介质完全匹配层(uniaxial anisotropic media perfectly matched layer, UPML)吸收边界条件以及近-远场外推边界条件的三维迭代式。通过典型算例, 先后验证了基于面中心立方体网格的时域有限差分(FCC-finite difference time domain, FCC-FDTD)方法的UPML吸收边界条件和近远场外推边界条件的正确性。最后通过计算金属球的后向雷达散射截面(radar cross section, RCS)比较了FCC-FDTD方法与传统FDTD方法的计算精度, 结果显示FCC-FDTD方法具有更高的计算精度。     

孕早期睡眠时长与午睡频次对妊娠糖尿病的影响

目的探讨孕早期睡眠时长和午睡频次对妊娠糖尿病(GDM)的影响。方法采用病例对照研究设计,选取2018年4月至2019年5月在安徽省妇幼保健院、吉安市妇幼保健院产检的孕妇作为研究对象。通过问卷调查收集研究对象的睡眠和午睡等信息,GDM的诊断来自孕中期常规口服葡萄糖耐量试验结果。结果共纳入500名研究对象,其中病例组196人,对照组304人。多元Logistic回归分析结果显示,与睡眠时长7～8.9 h/晚相比,睡眠7、9～9.9、≥10 h/晚的孕妇发生GDM的风险均显著上升;与午睡频次≤5 d/周相比,5 d/周的孕妇发生GDM的风险更高。相比孕早期午睡频率≤5 d/周的孕妇,孕早期睡眠时长不足(7 h/晚)对GDM的影响在午睡频率5 d/周的孕妇中更弱,交互作用具有统计学意义(P=0.002)。结论孕早期睡眠时长、午睡频次均与GDM发病相关,且二者在GDM的发生中存在交互作用。     

基于知识图谱的核电设备健康管理知识建模与分析

随着信息技术发展,设备健康数据与知识图谱技术结合为设备健康发展带来新的发展机遇,知识图谱利用其多种特异性优势,使企业系统中积累的海量设备维修数据得到有效整合利用.本文提出基于知识图谱的核电设备健康管理知识建模与分析方法,并根据实体关系模型构建维修知识图谱本体框架,同时基于核电企业实际的维修工单数据,从统计分析和关联分析两方面取得良好的实践效果.研究结果表明,知识图谱能够在设备维修知识的集成上解决传统的数据孤岛问题,同时能基于故障的可视化分析为维修人员和管理人员提供决策和知识支持.     

Impact of the RMB Joining in the SDR Basket on Its Internationalization from the Perspective of Risk Spillover

For evaluating the influence of the Chinese renminbi(RMB) joining in the special drawing right(SDR) basket on RMB's internationalization, the authors systemically study the risk spillover networks and examine the dynamic relationship of exchange rates among the SDR currencies including the US dollar(USD), European Union euro(EUR), Japanese yen(JPY) and British pound(GBP).The empirical results demonstrate that the USD takes a dominant position and holds the biggest risk spillover to other currencies, and the RMB's inclusion to the SDR basket makes the risk spillover to get average, giving rise to the SDR currency system more stable to a certain degree. The inclusion of the RMB in the SDR not only can reduce the systematic risk of the SDR, but also has a certain impact on the international exchange rate markets. Nowadays, in front of the growing trade friction, more such researches could help to effectively deal with the currency disputes.     

Molecular function of the novel α7β2 nicotinic receptor

The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs.     

Macropinocytosis,mTORC1 and cellular growth control

The growth and proliferation of metazoan cells are driven by cellular nutrient status and by extracellular growth factors. Growth factor receptors on cell surfaces initiate biochemical signals that increase anabolic metabolism and macropinocytosis, an actin-dependent endocytic process in which relatively large volumes of extracellular solutes and nutrients are internalized and delivered efficiently into lysosomes. Macropinocytosis is prominent in many kinds of cancer cells, and supports the growth of cells transformed by oncogenic K-Ras. Growth factor receptor signaling and the overall metabolic status of the cell are coordinated in the cytoplasm by the mechanistic target-of-rapamycin complex-1 (mTORC1), which positively regulates protein synthesis and negatively regulates molecular salvage pathways such as autophagy. mTORC1 is activated by two distinct Ras-related small GTPases, Rag and Rheb, which associate with lysosomal membranes inside the cell. Rag recruits mTORC1 to the lysosomal surface where Rheb directly binds to and activates mTORC1. Rag is activated by both lysosomal luminal and cytosolic amino acids; Rheb activation requires phosphoinositide 3-kinase, Akt, and the tuberous sclerosis complex-1/2. Signals for activation of Rag and Rheb converge at the lysosomal membrane, and several lines of evidence support the idea that growth factor-dependent endocytosis facilitates amino acid transfer into the lysosome leading to the activation of Rag. This review summarizes evidence that growth factor-stimulated macropinocytosis is essential for amino acid-dependent activation of mTORC1, and that increased solute accumulation by macropinocytosis in transformed cells supports unchecked cell growth.