环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

乳腺癌组织中CacyBP/SIP的表达情况及临床病理意义

目的:探讨钙周期素结合蛋白(Cacy BP/SIP)在乳腺癌组织中的表达及临床病理意义。方法:应用免疫组织化学染色检测Cacy BP/SIP在86例乳腺癌组织、20例癌旁相对正常乳腺组织及16例乳腺腺病组织中的表达情况并分析临床病理意义。结果:免疫组织化学结果显示,在86例乳腺癌组织、20例癌旁组织、16例乳腺腺病组织中Cacy BP/SIP蛋白的阳性表达率分别为75.6%(65/86)、30.0%(6/20)和43.8%(7/16),差异有统计学意义(P<0.05);Cacy BP/SIP蛋白在乳腺癌组织中的表达与组织学分级、淋巴结转移及TNM分期有统计学意义(P<0.05);Cacy BP/SIP蛋白表达与ER(r=0.275)、HER2(r=0.256)有相关性(P<0.05)。结论:Cacy BP/SIP在乳腺癌组织中高表达,且与ER、HER2的表达呈正相关,可能作为癌基因参与乳腺癌的恶性表型。     

海洛因依赖者环境线索诱发心理生理反应

目的：了解海洛因依赖者对吸毒相关环境线索诱发反应。方法：对来自自愿戒毒机构的36例刚完成生理脱毒（康复早期）的海洛因依赖者和劳教戒毒机构112例康复期满1年的海洛因依赖者观看吸毒相关视频同时给予海洛因模拟物及吸毒用具刺激,于暴露前后自评渴求程度、情绪以及戒断症状反应;用生物反馈仪自动记录暴露前后的生理反应。结果：环境线索暴露后海洛因依赖者心理渴求、害怕／焦虑、抑郁／悲伤、戒断症状、心率、皮肤导电和肌电增高（P〈0．05）,中性／放松／自然降低（P〈0．05）。自愿戒毒机构康复早期海洛因依赖者环境诱发心率增高,比康复期满一年以上者更明显（P〈0．05）,其余与康复期长短无显著关系。结论：海洛因依赖者戒断康复期的延长并不会使渴求和环境诱发心理生理反应减弱或消褪。     

电缆T接线路故障测寻方法的探讨

本文对电缆T接线路的几种方式和常见的几种T接线路故障测寻方法进行了介绍。通过广州供电局110kV三景桂线T接电缆虚拟故障的测寻案例,采用几种故障测寻方法配合使用的方式,探讨了如何采取便捷方法对T接线路进行故障测寻的可能途径。同时对电缆线路的设计规划提出了作者自己的观点和建议。     

生物反馈结合线索暴露治疗降低海洛因依赖者药物线索反应

目的:了解生物反馈结合线索暴露治疗是否降低海洛因依赖者环境线索诱发渴求及心理生理反应.方法:采用前瞻性的队列研究将60例环境线索诱发心理渴求增高的康复期海洛因依赖者分成实验组(n=36)与对照组(n=24),对照组只进行劳教场所的常规帮教,实验组除帮教外进行12次生物反馈结合线索暴露治疗,评估治疗前后环境线索诱发心理渴求与心理生理反应情况.结果:两组治疗结束后,实验组环境诱发前、后的心理渴求,肌电和皮导得分均低于对照组[诱发前:心理渴求(3.06±7.26)mm vs.(22.32±20.26)mm、肌电(8.52±4.23)μV vs.(12.06±5.17)μV、皮导(2.14±1.43)μS vs.(4.61±2.24)μS;诱发后:心理渴求(6.97±10.30)vs.(33.14±25.40)mm、肌电(8.72±4.31)vs.(14.79±5.86)μV、皮导(2.15±1.33)vs.(4.49±2.59)μS,P≤0.01].结论:生物反馈结合线索暴露治疗可降低康复期海洛因依赖者渴求及环境诱发心理生理反应.     

上海地区海洛因注射者的HIV高危性行为分析

目的 我国爱滋病感染者中43%是海洛因注射者（IDUs），既往研究多关其高危注射行为，本研究将对IDUs中的高危性行为情况进行分析。方法 收集了上海141名住院戒毒者的临床资料、HIV、HBV、HCV感染情况、性行为、艾滋病毒/艾滋病（HIV/AIDS）相关知识和态度及其他社会心理学因素，并分析了海洛因注射者高危性行为的影响因素。结果 IDUs中高危性行为非常普遍：77%不能坚持使用避孕套，25.5%有多个性伙伴，48.2%有IDUs性伙伴，75.9%不了解对方HIV感染情况；首次吸毒年龄小、注射过量次数多、对避孕套的否定态度、共用不洁注射工具与不安全性行为有关的因素有，而未婚、继续使用避孕套意愿、自愿HIV检测等与安全性行为有关。结论 上海地区IDUs中高危性行为普遍存在，不能忽视对IDUs中高危行为的研究。     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

环境线索对戒断期海洛因依赖者神经电生理的影响

Objective To explore the changes of craving and neuro-electrophysiological reactions under the exposure of heroin-related cues in abstinent heroin dependents.Methods In this self-controlled study,382 abstinent heroin dependent patients watched video of heroin smoking and injecting situations,and in the meantime were exposed to herein simulacrum and apparatus after relaxation exercises.The neuroelectrophysiological reactions were mcagured with a multi-biofeedback instrument before and after the cue exposed.Self-reported craving was also assessed before and after cue exposed.Results The craving were increased[(18±22)mm vs.(29±29)mm,P＜0.01]after cue exposures compared to pre-exposure,EMG[(12±7)μN vs.(14±10)μV,P＜0.01]and SC[(6.8±4.3)μS vs.(7.4±4.3)μS,P＜0.01]also increased.But the percentages of δ,θ,α,SMR,low β,high β decreased compared to that under the cue exposures[8:(10.8±4.7)%vs.(9.7±4.4)%,P＜0.01;0:(6.8±2.0)%vs.(6.3±2.0)%,P＜0.01;α:(4.8±1.8)%vs.(4.5±1.7)%,P＜0.01;SMR:(3.0 ±1.2)%vs.(2.8±1.2)%,P＜0.01;low β:(2.6±1.1)%vs.(2.5±1.1)%,P＜0.01 and high β:(4.6 ±1.5)%vs.(4.5±1.5)%.P＜0.05].Conclusions The results indicate that drug-related cue induce heroin craving and electrophysiological reactions.     

子宫颈鳞状细胞癌中HIF-1α、VEGF的表达及微血管密度测定

目的:探讨缺氧诱导因子-1α(HIF-1α)、血管内皮细胞生长因子(VEGF)、微血管密度(MVD)在不同宫颈病变组织中的表达特点及与临床病理特征的关系。方法:应用免疫组织化学SP法检测14例慢性宫颈炎、16例CINⅠ级、19例CINⅡ~Ⅲ级和65例宫颈鳞癌组织中HIF-1α和VEGF的表达情况,用CD34检测微血管密度。结果:HIF-1α在慢性宫颈炎、CINⅠ级、CINⅡ~Ⅲ级和宫颈鳞癌中的阳性率分别为0.00%、12.50%、31.58%和75.38%;VEGF在以上病变中的阳性率分别为0.00%、18.75%、36.84%和72.31%。HIF-1α和VEGF在宫颈鳞癌中的表达明显高于炎症组、CINⅠ级组和CINⅡ~Ⅲ级组,差异有统计学意义(P<0.05)。HIF-1α和VEGF的表达与患者临床分期、病理组织分型和淋巴结转移有关(P<0.05),与患者年龄无关。MVD和HIF-1α、VEGF的表达特点相同,在子宫颈鳞癌中HIF-1α、VEGF和MVD的表达水平呈正相关(P<0.01)。结论:HIF-1α和VEGF在子宫颈鳞癌中的高表达、MVD值的高水平可能在子宫颈鳞癌的发生、发展和转移中发挥重要作用,可以作为诊断和治疗的新靶点。     

苯丙胺类物质滥用者大脑结构改变的磁共振成像研究进展

苯丙胺类物质主要是指于上世纪末开始出现的甲基苯丙胺(冰毒)、3,4-亚甲基二氧基甲基苯丙胺(摇头丸)等新型毒品.同海洛因、可卡因等传统毒品相比,新型毒品具有精神依赖性强、认知功能损害明显等特点[1].