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Marta Gabasa Marselina Arshakyan Alejandro Llorente Lourdes Chuli-Peris Irina Pavelescu Antoni Xaubet Javier Pereda Jordi Alcaraz 《International journal of molecular sciences》2020,21(22)
Pro-inflammatory cytokines like interleukin-1β (IL-1β) are upregulated during early responses to tissue damage and are expected to transiently compromise the mechanical microenvironment. Fibroblasts are key regulators of tissue mechanics in the lungs and other organs. However, the effects of IL-1β on fibroblast mechanics and functions remain unclear. Here we treated human pulmonary fibroblasts from control donors with IL-1β and used Atomic Force Microscopy to unveil that IL-1β significantly reduces the stiffness of fibroblasts concomitantly with a downregulation of filamentous actin (F-actin) and alpha-smooth muscle (α-SMA). Likewise, COL1A1 mRNA was reduced, whereas that of collagenases MMP1 and MMP2 were upregulated, favoring a reduction of type-I collagen. These mechanobiology changes were functionally associated with reduced proliferation and enhanced migration upon IL-1β stimulation, which could facilitate lung repair by drawing fibroblasts to sites of tissue damage. Our observations reveal that IL-1β may reduce local tissue rigidity by acting both intracellularly and extracellularly through the downregulation of fibroblast contractility and type I collagen deposition, respectively. These IL-1β-dependent mechanical effects may enhance lung repair further by locally increasing pulmonary tissue compliance to preserve normal lung distension and function. Moreover, our results support that IL-1β provides innate anti-fibrotic protection that may be relevant during the early stages of lung repair. 相似文献
3.
Konstantin V. Dergilev Evgeny K. Shevchenko Zoya I. Tsokolaeva Irina B. Beloglazova Ekaterina S. Zubkova Maria A. Boldyreva Mikhail Yu. Menshikov Elizaveta I. Ratner Dmitry Penkov Yelena V. Parfyonova 《International journal of molecular sciences》2020,21(24)
Cell therapy of the post-infarcted myocardium is still far from clinical use. Poor survival of transplanted cells, insufficient regeneration, and replacement of the damaged tissue limit the potential of currently available cell-based techniques. In this study, we generated a multilayered construct from adipose-derived mesenchymal stromal cells (MSCs) modified to secrete stem cell factor, SCF. In a rat model of myocardium infarction, we show that transplantation of SCF producing cell sheet induced activation of the epicardium and promoted the accumulation of c-kit positive cells in ischemic muscle. Morphometry showed the reduction of infarct size (16%) and a left ventricle expansion index (0.12) in the treatment group compared to controls (24–28%; 0.17–0.32). The ratio of viable myocardium was more than 1.5-fold higher, reaching 49% compared to the control (28%) or unmodified cell sheet group (30%). Finally, by day 30 after myocardium infarction, SCF-producing cell sheet transplantation increased left ventricle ejection fraction from 37% in the control sham-operated group to 53%. Our results suggest that, combining the genetic modification of MSCs and their assembly into a multilayered construct, we can provide prolonged pleiotropic effects to the damaged heart, induce endogenous regenerative processes, and improve cardiac function. 相似文献
4.
Felix Rivkin Irina Kuznetsova Nadezhda Ivanova Sergey Suhodolsky 《Soil Mechanics and Foundation Engineering》2002,39(1):42-43
Soil Mechanics and Foundation Engineering - 相似文献
5.
A novel approach is presented to calculate the sensitivities of the scattering parameters of microwave filters obtained with the full‐wave mode‐matching (MM) technique. Using only the MM simulation of the original network, the sensitivities of the scattering parameters with respect to all designable parameters are obtained. The adjoint network method (ANM) is applied to the generalized scattering matrices of the different filter components. This guarantees good accuracy of the calculated sensitivities. The implementation details are discussed for N‐resonator ridge waveguide filters. Excellent agreement is obtained between the sensitivities calculated using ANM and those obtained using the expensive central differences. © 2006 Wiley Periodicals, Inc. Int J RF and Microwave CAE, 2006. 相似文献
6.
Kouzaev G.A. Deen M.J. Nikolova N.K. Rahal A.H. 《Microwave and Wireless Components Letters, IEEE》2004,14(6):265-267
We study the influence of the technologically caused eccentricity of a circular-pad via-hole. We derive an eigenvalue equation using a rigorous method based on a linear transformation of the via-hole polar coordinates. The eigenvalue equation is used to compute the modal resonant frequencies and the modal fields of the eccentric via. It is shown that the via-hole misalignment shifts the modal frequencies and influences its frequency band. The proposed model is verified with published experimental data, and is also compared with results generated with the full-wave simulator Agilent Momentum-2002. 相似文献
7.
The standard impact factor as an evaluation tool of science fields and scientific journals 总被引:2,自引:2,他引:0
Irina Marshakova-Shaikevich 《Scientometrics》1996,35(2):283-290
The standard impact factor for particular fields of science (Ig) and the relative impact factor K for scientific journals are introduced. The technique of calculation of standard impact factor (Ig) for a field is an inherent part of a method which allows a cross-field evaluation of scientific journals. This method for evaluating scientific journals elaborated in 1988 was aimed at the analysis of Russian journals covered by the SCI database, it was also used for chemical journals (more that 300) and for journals in the Life sciences (more than 1000). The results are discussed. 相似文献
8.
Quantum-mechanical reaction rate constants were calculated from centroid molecular dynamics (CMD) simulations, for the case of barrier crossing in an asymmetrical double-well potential bilinearly coupled to a harmonic bath. The calculation is based on a recently proposed formulation of the reaction rate constant in terms of the position—flux correlation function, which can be approximated via CMD in a well-defined manner. The predictions of CMD and various simplified versions of it are compared to exact results, which were obtained via the quasi-adiabatic propagator path integral (QUAPI) method, and/or path integral quantum transition state theory (PI-QTST). The predictions based on CMD are found to be in good agreement with both. 相似文献
9.
Irina Naydenova Torleiv Klove 《IEEE transactions on information theory / Professional Technical Group on Information Theory》2007,53(3):1188-1193
Bose and Lin introduced a class of systematic codes for detection of binary asymmetric errors. In this note, we describe a generalization to q-ary asymmetric error detecting codes. For these codes, the possible undetectable errors are characterized and the undetectable errors of minimum weight are determined 相似文献
10.