A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia

Non-obstructive azoospermia (NOA) is one of the most severe forms of male infertility. Its pathophysiology is largely unknown, and few genetic influences have been defined. To identify common variants contributing to NOA in Han Chinese men, we performed a three-stage genome-wide association study of 2,927 individuals with NOA and 5,734 controls. The combined analyses identified significant (P < 5.0 × 10(-8)) associations between NOA risk and common variants near PRMT6 (rs12097821 at 1p13.3: odds ratio (OR) = 1.25, P = 5.7 × 10(-10)), PEX10 (rs2477686 at 1p36.32: OR = 1.39, P = 5.7 × 10(-12)) and SOX5 (rs10842262 at 12p12.1: OR = 1.23, P = 2.3 × 10(-9)). These findings implicate genetic variants at 1p13.3, 1p36.32 and 12p12.1 in the etiology of NOA in Han Chinese men.     

Deep structure at northern margin of Tarim Basin

In this paper, a 2D velocity structure of the crust and the upper mantle of the northern margin of the Tarim Basin （TB） has been obtained by ray tracing and theoretical seismogram calculation under the condition of 2D lateral inhomogeneous medium using the data of seismic wide angle reflection/refraction profile from Baicheng to Da Qaidam crossing the Kuqa Depression （KD） and Tabei Uplift （TU）. And along the Baicheng to Da Qaidam profile, 4 of the 10 shot points are located in the northern margin of the TB. The results show that the character of the crust is uniform on the whole between the KD and TU, but the depth of the layers, thickness of the crust and the velocity obviously vary along the profile. Thereinto, the variation of the crust thickness mainly occurs in the middle and lower crust. The Moho has an uplifting trend near the Baicheng shot point in KD and Luntai shot point in TU, and the thickness of the crust reduces to 42 km and 47 km in these two areas, respectively. The transition zone between the KD and TU has a thickest crust, up to 52 km. In this transition zone, there are high velocity anoma- lies in the upper crust, and low velocity anomalies in the lower crust, these velocity anomalies zone is near vertical, and the sediment above them is thicker than the other areas. According to the velocity distributions, the profile can be divided into three sections： KD, TU and transition zone between them. Each section has a special velocity structural feature, the form of the crystalline basement and the relationship between the deep structure and the shallow one. The differences of velocity and tectonic between eastern and western profile in the northern margin of the Tarim Basin （NMTB） may suggest different speed and intensity of the subduction from the Tarim basin to the Tianshan orogenic belt （TOB）.     

生物补钙和磷

钙是人体必须的基本元素之一,作为一种营养元素,它对生命有有着不可低估的作用,钙缺乏常会引起多种疾病的发生,成人体内钙总量为1000---1200克。然而,在对全国膳食调查中却发现,国人膳食中钙的摄入量还达不到每日供给需要的一半,仅为400mg左右。而磷则主要组成骨、牙,维护体液的酸碱平衡。本实验通过化学与生物的有机连续,将骨骼中的钙、磷通过简单的化学处理使人们在膳食的过程中补充钙和磷,该方法经济实惠,又易于操作和掌握,是一个具有较大潜力的科研项目。     

行星际日冕物质抛射中的磁流体波动观测

日冕物质抛射（CME）是最大尺度的太阳活动现象,灾害性空间天气的主要驱动源．行星际日冕物质抛射（ICME）中的等离子体波动性质与ICME的演化密切相关．由于ICME中的平均磁场较大,其中的Alfven低频扰动研究较少．前人的研究只分析了0．3AU和0．68AU处的个别ICME中的Alfven波动．ICME在1AU处的Alfven波观测较少．本文对第23太阳周1995—2006年期间所有引起大磁暴（Dst≤－100nT）的单个ICME事件进行统计分析,结果表明：（1）大约30％的ICME中长时间存在Alfven波（超过ICME持续时间的30％）;（2）约一半的ICME的鞘层中存在快磁声波;（3）所有ICME中都存在短时间段的慢磁声波．这些观测结果为研究CME在行星际传播过程时其中的Alfven波演化机制及其动力学演化提供了观测基础．     

高升力多段机翼的转捩预测研究

本文采用Menter等发展的基于局部变量的γ-Reθt湍流转捩模式对平板和NLR7301翼型开展了转捩模式验证工作,进而对带有前、后缘襟翼的多段机翼流动转捩进行了数值模拟.研究结果表明,转捩对于多段机翼的气动特性具有较大影响,数值模拟可为多段机翼中襟翼偏角、间距等设计提供有益指导.