High critical current density and enhanced irreversibility field in superconducting MgB2 thin films

The discovery of superconductivity at 39 K in magnesium diboride offers the possibility of a new class of low-cost, high-performance superconducting materials for magnets and electronic applications. This compound has twice the transition temperature of Nb3Sn and four times that of Nb-Ti alloy, and the vital prerequisite of strongly linked current flow has already been demonstrated. One possible drawback, however, is that the magnetic field at which superconductivity is destroyed is modest. Furthermore, the field which limits the range of practical applications-the irreversibility field H*(T)-is approximately 7 T at liquid helium temperature (4.2 K), significantly lower than about 10 T for Nb-Ti (ref. 6) and approximately 20 T for Nb3Sn (ref. 7). Here we show that MgB2 thin films that are alloyed with oxygen can exhibit a much steeper temperature dependence of H*(T) than is observed in bulk materials, yielding an H* value at 4.2 K greater than 14 T. In addition, very high critical current densities at 4.2 K are achieved: 1 MA cm-2 at 1 T and 105 A cm-2 at 10 T. These results demonstrate that MgB2 has potential for high-field superconducting applications.     

The recent expansion of Pluto's atmosphere

Stellar occultations--the passing of a relatively nearby body in front of a background star--can be used to probe the atmosphere of the closer body with a spatial resolution of a few kilometres (ref. 1). Such observations can yield the scale height, temperature profile, and other information about the structure of the occulting atmosphere. Occultation data acquired for Pluto's atmosphere in 1988 revealed a nearly isothermal atmosphere above a radius of approximately 1,215 km. Below this level, the data could be interpreted as indicating either an extinction layer or the onset of a large thermal gradient, calling into question the fundamental structure of this atmosphere. Another question is to what extent Pluto's atmosphere might be collapsing as it recedes from the Sun (passing perihelion in 1989 in its 248-year orbital period), owing to the extreme sensitivity of the equilibrium surface pressure to the surface temperature. Here we report observations at a variety of visible and infrared wavelengths of an occultation of a star by Pluto in August 2002. These data reveal evidence for extinction in Pluto's atmosphere and show that it has indeed changed, having expanded rather than collapsed, since 1988.     

Ozone production by a corona-type loudspeaker and its toxic effects in mice

Résumé L'ionophone est un émetteur sonique et ultra-sonique qui utilise la particularité qu'ont les gaz d'être ionisés sous l'effet d'une tension électrique très élevée et de haute fréquence. Ce générateur est aussi un ozoniseur efficient et il est nécessaire de ne l'employer qu'avec une ventilation appropriée.

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Paper No. 2397 in the Journal Series of the Agricultural Experiment Station.     

Charon's radius and atmospheric constraints from observations of a stellar occultation

The physical characteristics of Pluto and its moon, Charon, provide insight into the evolution of the outer Solar System. Although previous measurements have constrained the masses of these bodies, their radii and densities have remained uncertain. The observation of a stellar occultation by Charon in 1980 established a lower limit on its radius of 600 km (ref. 3) (later refined to 601.5 km; ref. 4) and suggested a possible atmosphere. Subsequent, mutual event modelling yielded a range of 600-650 km (ref. 5), corresponding to a density of 1.56 +/- 0.22 g cm(-3) (refs 2, 5). Here we report multiple-station observations of a stellar occultation by Charon. From these data, we find a mean radius of 606 +/- 8 km, a bulk density of 1.72 +/- 0.15 g cm(-3), and rock-mass fraction 0.63 +/- 0.05. We do not detect a significant atmosphere and place 3sigma upper limits on atmospheric number densities for candidate gases. These results seem to be consistent with collisional formation for the Pluto-Charon system in which the precursor objects may have been differentiated, and they leave open the possibility of atmospheric retention by the largest objects in the outer Solar System.     

Initiation and re-initiation of DNA unwinding by the Escherichia coli Rep helicase

Helicases are motor proteins that couple conformational changes induced by ATP binding and hydrolysis with unwinding of duplex nucleic acid, and are involved in several human diseases. Some function as hexameric rings, but the functional form of non-hexameric helicases has been debated. Here we use a combination of a surface immobilization scheme and single-molecule fluorescence assays--which do not interfere with biological activity--to probe DNA unwinding by the Escherichia coli Rep helicase. Our studies indicate that a Rep monomer uses ATP hydrolysis to move toward the junction between single-stranded and double-stranded DNA but then displays conformational fluctuations that do not lead to DNA unwinding. DNA unwinding initiates only if a functional helicase is formed via additional protein binding. Partial dissociation of the functional complex during unwinding results in interruptions ('stalls') that lead either to duplex rewinding upon complete dissociation of the complex, or to re-initiation of unwinding upon re-formation of the functional helicase. These results suggest that the low unwinding processivity observed in vitro for Rep is due to the relative instability of the functional complex. We expect that these techniques will be useful for dynamic studies of other helicases and protein-DNA interactions.     

Effects of intense noise on adrenal and plasma cholesterol of mice

Résumé Nos expériences sur l'effet du bruit intense sur l'activité des surrénales des souris ont donné les résultats suivants: 1° la cholestérine des surrénales et la cholestérine sanguine demeurent inchangées, 2° nous n'avons pas pu obtenir les signes d'hypertrophie de la surrénale ou d'atrophie du thymus après 1 à 4 semaines d'excitations par le bruit (5 min par jour). On constate done que chez les souris périodiquement soumises à un bruit intense mais de courte durée, le cortex surrénalien ne subit pas d'augmentation excessive.     

Mutations in MYH9 result in the May-Hegglin anomaly, and Fechtner and Sebastian syndromes. The May-Heggllin/Fechtner Syndrome Consortium

The autosomal dominant, giant-platelet disorders, May-Hegglin anomaly (MHA; MIM 155100), Fechtner syndrome (FTNS; MIM 153640) and Sebastian syndrome (SBS), share the triad of thrombocytopenia, large platelets and characteristic leukocyte inclusions ('D?hle-like' bodies). MHA and SBS can be differentiated by subtle ultrastructural leukocyte inclusion features, whereas FTNS is distinguished by the additional Alport-like clinical features of sensorineural deafness, cataracts and nephritis. The similarities between these platelet disorders and our recent refinement of the MHA (ref. 6) and FTNS (ref. 7) disease loci to an overlapping region of 480 kb on chromosome 22 suggested that all three disorders are allelic. Among the identified candidate genes is the gene encoding nonmuscle myosin heavy chain 9 (MYH9; refs 8-10), which is expressed in platelets and upregulated during granulocyte differentiation. We identified six MYH9 mutations (one nonsense and five missense) in seven unrelated probands from MHA, SBS and FTNS families. On the basis of molecular modelling, the two mutations affecting the myosin head were predicted to impose electrostatic and conformational changes, whereas the truncating mutation deleted the unique carboxy-terminal tailpiece. The remaining missense mutations, all affecting highly conserved coiled-coil domain positions, imparted destabilizing electrostatic and polar changes. Thus, our results suggest that mutations in MYH9 result in three megakaryocyte/platelet/leukocyte syndromes and are important in the pathogenesis of sensorineural deafness, cataracts and nephritis.     

A new section of Kaili Formation (Cambrian) and a biostratigraphic study of the boundary interval across the undefined Cambrian Series 2 and Series 3 at Jianshan, Jianhe County,China with a discussion of global correlation based on the first appearance datum of Oryctocephalus indicus(Reed,1910)

A trilobite biostratigraphic study of a new section of the Kaili Formation at Jianshan,Chuandong Village,Jianhe County,Guizhou is reported.Additional occurrences of key species associated with the Ovatoryctocara granulata-Bathynotus holopygus Zone and the overlying Oryctocephalus indicus Zone that were originally defined from the trilobite assemblages at the Wuliu-Zengjiayan section of the Kaili are reported from this new section.The first appearance datum (FAD) of Oryctocephalus indicus occurs at the 44.52 m above the base of the unit.Based on study of abundant specimens (n = 800) from the Kaili Formation,we argue that Oryctocephalus indicus is a widespread taxon with a global distribution.O.Reticulatus (Lermontova,1940) from the middle part of the Kounamkites Zone of the Amganian Stage in the Molodo River region of Siberia and O.Americanus (Sundberg and McCollum,2003) from Nevada,North America are similar to representatives of O.Indicus which occur in the O.Indicus Zone of the Kaili Formation.O.Reticulatus and O.Americanus are here synonymized with O.Indicus (Reed,1910).This study strengthens the Wuliu-Zengjiayan section of the Kaili Formation as a candidate section for a Global Stratotype for the base of the unnamed Cambrian Series 3.