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1.
Epigenetic asymmetry of imprinted genes in plant gametes   总被引:12,自引:0,他引:12  
Plant imprinted genes show parent-of-origin expression in seed endosperm, but little is known about the nature of parental imprints in gametes before fertilization. We show here that single differentially methylated regions (DMRs) correlate with allele-specific expression of two maternally expressed genes in the seed and that one DMR is differentially methylated between gametes. Thus, plants seem to have developed similar strategies as mammals to epigenetically mark imprinted genes.  相似文献   
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Mitogenic stimulation of the host enhances susceptibility to scrapie   总被引:2,自引:0,他引:2  
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Reduced susceptibility to scrapie in mice after steroid administration   总被引:3,自引:0,他引:3  
G W Outram  A G Dickinson  H Fraser 《Nature》1974,249(460):855-856
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Elimination of ribosomes during meiotic prophase   总被引:3,自引:0,他引:3  
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The source of Galactic cosmic rays (with energies up to 10(15) eV) remains unclear, although it is widely believed that they originate in the shock waves of expanding supernova remnants. At present the best way to investigate their acceleration and propagation is by observing the gamma-rays produced when cosmic rays interact with interstellar gas. Here we report observations of an extended region of very-high-energy (> 10(11) eV) gamma-ray emission correlated spatially with a complex of giant molecular clouds in the central 200 parsecs of the Milky Way. The hardness of the gamma-ray spectrum and the conditions in those molecular clouds indicate that the cosmic rays giving rise to the gamma-rays are likely to be protons and nuclei rather than electrons. The energy associated with the cosmic rays could have come from a single supernova explosion around 10(4) years ago.  相似文献   
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Distribution of experimentally induced scrapie lesions in the brain   总被引:2,自引:0,他引:2  
H Fraser  A G Dickinson 《Nature》1967,216(5122):1310-1311
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