Mutations in LMF1 cause combined lipase deficiency and severe hypertriglyceridemia

Hypertriglyceridemia is a hallmark of many disorders, including metabolic syndrome, diabetes, atherosclerosis and obesity. A well-known cause is the deficiency of lipoprotein lipase (LPL), a key enzyme in plasma triglyceride hydrolysis. Mice carrying the combined lipase deficiency (cld) mutation show severe hypertriglyceridemia owing to a decrease in the activity of LPL and a related enzyme, hepatic lipase (HL), caused by impaired maturation of nascent LPL and hepatic lipase polypeptides in the endoplasmic reticulum (ER). Here we identify the gene containing the cld mutation as Tmem112 and rename it Lmf1 (Lipase maturation factor 1). Lmf1 encodes a transmembrane protein with an evolutionarily conserved domain of unknown function that localizes to the ER. A human subject homozygous for a deleterious mutation in LMF1 also shows combined lipase deficiency with concomitant hypertriglyceridemia and associated disorders. Thus, through its profound effect on lipase activity, LMF1 emerges as an important candidate gene in hypertriglyceridemia.     

岷江上游花椒地/林地边界土壤水分分布及影响域

在岷江上游干旱河谷区选取典型的花椒地,林地边界,利用TDR仪测定干旱条件下和雨后0-15cm表土层水分体积分数,刻画沿样带梯度土壤水分分布以及不同时段土壤水分变化,同时用移动窗口法判定土壤水分的边界影响域。结果表明,在干旱河谷区土壤水分体积分数较低并沿样带存在明显的变化,从林地到边界到花椒地土壤水分体积分数基本呈“V”字型变化;而在林地和花椒地内部,水分体积分数呈“W”型波动。干旱时土壤水分体积分数日间变化不大,而雨后水分体积分数逐日递减。土壤水分的影响域在雨后可达14m,干旱时为8m。     

基于3D-CDF(2,2)和3D SPIHT的序列图像压缩编码研究

研究了3D DWT和3D SPIHT算法,用CDF（2,2）双正交小波为帧内小波变换的小波基,考虑到边界延拓效应,时间维小波变换也选用CDF（2,2）双正交小波为时间维小波变换的小波基,实验结果表明算法对于视频序列图像压缩是非常有效的,其压缩效果明显优于基于3D-DCT的压缩编码算法.