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排序方式: 共有128条查询结果,搜索用时 267 毫秒
1.
A. V. Meera S. Sen P. Raghupathy D. Walter M. Chandy H. Krishnaswami J. Chacko N. Zachariah K. E. Mammen 《Pediatric surgery international》1995,10(5-6):389-390
We present two children with massive bleeding into the serous body cavities accompanied by intractable consumption coagulopathy. One had a large spleen palpable at admission, the other developed progressive splenomegaly while in hospital. Neither child had any external evidence of angiomatous lesions. A splenic hemangioma was suspected clinically and on abdominal ultrasound; the diagnosis was confirmed at laparotomy. Splenectomy resulted in a prompt cure in both cases. 相似文献
2.
Jebaraj R Cherian T Raghupathy P Brahmadathan KN Lalitha MK Thomas K Steinhoff MC 《Epidemiology and infection》1999,123(3):383-388
To investigate the dynamics of nasopharyngeal colonization with Streptococcus pneumoniae, and to determine the prevalent serogroups/types (SGT) and their antimicrobial susceptibility, we studied 100 infants attending our well-baby clinic. Nasopharyngeal swab specimens were obtained at 6, 10, 14, 18 and 22 weeks and at 9 and 18 months of age and submitted for culture, serotyping and antimicrobial susceptibility testing of S. pneumoniae. Colonization with pneumococcus was seen on at least one occasion in 81 infants. The median age of acquisition was 11 weeks and the median duration of carriage was 1 3 months. The common SGTs identified were 6, 19, 14 and 15. SGT 1, which was a common invasive isolate in children in our hospital during this period, was not isolated from these children. Sequential colonization by 2, 3 or 4 SGTs was observed in 18, 5 and 2 children, respectively. Resistance to penicillin, chloramphenicol, cotrimoxazole and erythromycin was observed in 0, 13 (6%) 11 (5 %) and 5 (3 %) isolates, respectively. There was a significant difference in susceptibility to cotrimoxazole between colonizing and invasive isolates (5 % vs. 40 %, P<0.0001). 相似文献
3.
Stimulation of adrenergic activity by desipramine enhances hematopoietic stem and progenitor cell mobilization along with G‐CSF in multiple myeloma: A pilot study 下载免费PDF全文
Aditi Shastri Anjali Budhathoki Stefan K. Barta Noah Kornblum Olga Derman Ramakrishna Battini Radha Raghupathy Amit K. Verma Paul S. Frenette Ira Braunschweig Murali Janakiram 《American journal of hematology》2017,92(10):1047-1051
Hematopoietic stem cell (HSC) release is positively regulated by the sympathetic nervous system through the β3 adrenergic receptor. Preclinical studies have demonstrated that the combination of desipramine and G‐CSF resulted in improved HSC mobilization. Here, we present the results of an open‐label single‐arm pilot study in patients with multiple myeloma undergoing autologous stem cell transplantation (ASCT) to assess the safety and efficacy of desipramine combined with G‐SCF to induce HSC mobilization. The primary endpoint was safety of the combination including engraftment kinetics. The secondary endpoint was the proportion of patients who collected ≥5 × 106 CD34+ cells/kg. Outcomes were compared with historical matched controls during the same time period with multiple myeloma mobilized with G‐CSF. All study patients received desipramine 100 mg daily for 7 days, starting 4 days prior to G‐CSF administration (D‐3) and continued taking it along with G‐CSF for a total of 7 days. Six of ten patients enrolled completed the protocol with minimal side effects. All of them achieved the target collection of 5 × 106 CD34 cells/kg in a median of 1.5 apheresis session with two patients needing additional plerixafor (16%), while 11 out of 13 patients (85%) achieved the target of 5 × 106 CD34 cells/kg in the historical control group in a median of 2 apheresis procedures and seven patients needed plerixafor (54%). The combination of desipramine and G‐CSF is safe and signals improved mobilization over G‐CSF alone, providing a possible alternative means of mobilization that needs further investigation. 相似文献
4.
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Imayavaramban Lakshmanan Sanjib Chaudhary Raghupathy Vengoji Parthasarathy Seshacharyulu Satyanarayana Rachagani Joseph Carmicheal Rahat Jahan Pranita Atri Ramakanth ChirravuriVenkata Rohitesh Gupta Saravanakumar Marimuthu Naveenkumar Perumal Sanchita Rauth Sukhwinder Kaur Kavita Mallya Lynette M. Smith Subodh M. Lele Moorthy P. Ponnusamy Mohd W. Nasser Ravi Salgia Surinder K. Batra Apar Kishor Ganti 《Molecular oncology》2021,15(7):1866
6.
A. P. Patel Mammen Chandy P. Raghupathy Chellam Kirubakaran Uma Khanduri 《Indian journal of pediatrics》1993,60(3):441-444
Twelve cases of hereditary factor XIII (FX III) deficiency diagnosed over five years (1986–1990) at Christian Medical College
and Hospital, Vellore are presented here. Although all the cases had a history of umbilical cord bleeding and subsequent frequent
bleeding episodes, diagnosis was considerably delayed. All but two patients required transfusions for bleeding episodes. Ten
patients had a history of consanguinity in parents. Clinical features and family history are described in detail here. The
ease of performing the Urea solubility test and problems in it's interpretation are highlighted. The role of prophylactic
transfusion is also discussed. 相似文献
7.
Bhasker B Raghupathy P Nair TM Ahmed SR deSilva V Bhuyan BC Al Khusaiby SM 《Archives of disease in childhood》1999,81(6):505-507
This paper reports a new finding in two siblings with primary hypomagnesaemia as a result of renal magnesium wasting, namely, rapidly increasing head size. External hydrocephalus and brain shrinkage in primary hypomagnesaemia seen on computed tomography of the brain with reversibility after magnesium treatment has not been reported previously. 相似文献
8.
We report a case of aspiration of calcium carbonate powder by a toddler. Bronchoscopic removal of aspirated contents resulted in favourable outcome. 相似文献
9.
Makhseed M Raghupathy R El-Shazly S Azizieh F Al-Harmi JA Al-Azemi MM 《American journal of reproductive immunology (New York, N.Y. : 1989)》2003,49(5):308-318
PROBLEM: The objective of this study was to determine the levels of cytokines produced by maternal peripheral blood mononuclear cells (PBMC) upon stimulation with a mitogen, with autologous placental cells and with a trophoblast antigen extract. METHOD OF STUDY: Peripheral blood mononuclear cells from 54 women with a history of successful pregnancy and 30 women undergoing preterm delivery (PTD) were stimulated with the mitogen and antigens, and the cytokine levels in mitogen-stimulated culture supernatants assessed. RESULTS: Significantly higher levels of the type 1 cytokines, interferon (IFN)-gamma and interleukin (IL)-2, were produced by the PTD group than by the normal pregnancy group, which on the contrary showed significantly greater production of the type 2 cytokines, IL-4, IL-5 and IL-10. A comparison of the ratios of type 2 to type 1 cytokines is indicative of a type 1 cytokine bias in PTD. CONCLUSIONS: These data are suggestive of a maternal type 1 cytokine bias in PTD. 相似文献
10.
Seventy-eight children were treated for the haemolytic-uraemic syndrome complicating bacillary dysentery over a ten-year period. Early dialysis favoured survival significantly. The renal status of 22 of the 28 survivors was re-evaluated 18-84 months after initial hospitalization. Complete recovery was found in all except two patients; one of them had neurological sequelae and the other a glomerulonephritic disease. 相似文献