鼻腔鼻窦黑色素瘤（附4例报告）

鼻腔鼻窦黑色素瘤（附４例报告）杨恩英，张燕，范呈晓，张杰英，魏守礼附属二院耳鼻咽喉科（０５００００）附属二院病理科关键词鼻科；副鼻窦；肿瘤；恶性原发鼻腔、鼻窦黑色素瘤少见，尤其无色黑色素瘤临床常误诊为息肉。本文统计７年鼻腔，鼻窦恶性肿瘤１６９例，其中...     

头颅、椎管内原发性滑膜肉瘤二例

例1 男,26岁。腰痛伴双下肢麻木40天,下肢瘫痪,小便失禁20天。检查:腰_3棘突叩击痛,胸_(11)以下浅感觉消失,双下肢软瘫。X线平片示胸_8下缘骨质破坏。脊髓碘油造影:腰_3完全梗阻。术中见腰_(1～4)硬脊膜外烂鱼肉样肿瘤,两端未见正常     

胃肠道正常组织与癌组织超氧化物歧化酶免疫组织化学及体视 …

自由基与肿瘤的发生、发展密切相关,近年来许多学者在这方面进行深入的研究.本文利用兔抗人超氧化物歧化酶(superoxide dismutase,SOD)抗血清对正常胃、小肠、结肠与对应癌组织SOD分布,进行免疫组化定位分析,且进一步利用体视学特征图像分析技术,定量分析各种组织的形态特征及其相关性.从另一角度探讨自由基与癌组织之间某些联系.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

胎膜早破孕妇羊水、血清中IL-6、IL-8与基质金属蛋白酶的相关性研究

目的探讨胎膜早破患者羊水及血清中IL-6、IL-8的水平,胎膜组织中基质金属蛋白酶(MMP-9)的表达情况,IL-6、IL-8与MMP-9是否有相关性.方法随机选择胎膜早破孕妇37例为实验组,其中Ⅰ组为足月胎膜早破22例,Ⅱ组为未足月胎膜早破患者15例,正常足月孕妇25例Ⅲ组作为对照组,用酶联免疫吸附实验测定母血及羊水中IL-6、IL-8水平,用免疫组化(SP)法测定胎膜中MMP-9的水平.结果实验组羊水及血清中IL-6、IL-8的水平明显高于对照组,具有显著性差异(P＜0.01);实验组胎膜组织中MMP-9表达水平高于对照组(P＜0.05);实验组母血及羊水中IL-6、IL-8均与胎膜组织中MMP-9有相关性(相关系数分别为0.882,0.729).结论母血及羊水中IL-6、IL-8水平变化可作为胎膜早破合并绒毛膜羊膜炎的诊断指标之一,基质金属蛋白酶(MMP-9)在感染引起的胎膜早破中起关键性作用,炎性细胞因子IL-6、Ⅱ-8通过诱导MMP-9的合成和活化,间接导致胎膜早破.     

脑星形细胞瘤中TIP30、VEGF和CD34的表达及其相关性研究

Objective To investigate the expression and relationship of TIP30(HIV-1 Tat interactive protein 2), vascular endothelial growth factor (VEGF) and MVD (detected by CD34) in the angiogenesis of human brain astrocytomas. Methods Expression of TIP30, VEGF and CD34 in 19 cases of normal brain tissue and 71 cases of astrocytoma were immunohistochemically examined with Elivision plus two-step method. Results The positive expression of TIP30 could be seen in cytoplasm of neuroglial cells and neurons of 19 normal brain tissues. The positive expression rate of TIP30 in 71 cases of astrocytoma was 33.80 % (24/ 71). The positive expression rate of TIP30 in astrocytoma of different grades was 52 % for grade Ⅱ, 34.78 % for grade Ⅲ and 13.04 % for grade Ⅳ. The positive expression rate of TIP30 in high grade (Ⅲ+Ⅳ) of astrocytoma was found significantly lower than that in low grade(Ⅱ) (χ2=5.71, P <0.05); The expression of VEGF and MVD detected by CD34 in astrocytomas were higher than that in normal brain tissue and increased as the tumor grade increased; In astrocytoma, the negtive correlation was found between the expression of TIP30 and VEGF (r=-0.428, P<0.05); no correlation was found between TIP30 and MVD(r=-0.065, P 0.05); the positive correlation was found between VEGF and MVD(r=0.684, P<0.01). Conclusion The positive expression rate of TIP30 in normal brain tissue is significantly higher than that in astrocytoma. The positive expression rate of TIP30 significantly decreases as the pathological grade of the astrocytoma increases; The expression of TIP30 and VEGF is negatively correlated in astrocytoma.     

钙黏蛋白及环氧合酶-2在妊娠期高血压疾病中的表达及意义

目的探讨上皮型钙黏蛋白（E—cadherin）及环氧合酶-2（COX-2）在妊娠期高血压疾病患者胎盘组织中的表达及相关性。方法采用免疫组织化学sP法检测妊娠期高血压组21例、子痫前期组17例和正常妊娠组20例胎盘组织E—cadherin及COX-2的表达情况。结果子痫前期组E—cadherin的表达较正常妊娠组显著升高（P〈0．01），COX-2的表达较正常妊娠组显著降低（P〈0．01）；妊娠期高血压疾病患者E—cadherin与COX-2的表达呈负相关（r=-0．371，P〈0．05）。结论胎盘组织局部E—cadherin及COX-2的改变与子痫前期的发生有关；E—cadherin的上调及COX-2的下调可能受同一因素的调控。     

锁骨钩钢板治疗肩锁关节脱位及锁骨远端骨折

目的 观察锁骨钩钢板治疗肩锁关节脱位及锁骨远端骨折的疗效.方法 对近3年来采用锁骨钩钢板治疗肩锁关节脱位及锁骨远端骨折30例总结分析.结果 经观察有效率高,优良率分别为86%和14%,效果理想.结论 利用锁骨钩钢板治疗肩锁关节脱位及锁骨远端骨折是一种有效的方法.