腰椎疾病的外科治疗新理念—腰椎肿瘤

随着脊柱外科技术和器械的不断改进，手术治疗腰椎肿瘤已被广泛接受。然而，由于腰椎解剖结构上的特殊性，很难象治疗四肢肿瘤一样用整块切除的方式达到广泛的切除，而不得不采取分块切除或刮除。     

虎力散胶囊致过敏性休克1例

患者女46岁。因腿部疼痛服用虎力散胶囊，每次0．3gbid，在服药后约0．5h，突然出现面色苍白，出冷汗，继而出现心慌、气短，出现晕觉摔倒在地，体温35．6℃，血压90／60mmHg，脉搏120次／min，呼吸24次／min。     

HPLC下罗红霉素及其制剂含量测定的研究

本文的目的是建立测定罗红霉素及其制剂含量的方法，应用HPLC（high performance liquid chromatography，高效液相色谱法，下同）法代替抗生素微生物检定法测定罗红霉素分散片含量；方法是以乙腈-甲醇-0．5％三乙胺（100：80：60）为流动相。采用高效液相色谱法测定；结果是精密度好，RSD=0．17％。结论是采用HPLC法测定罗红霉素分散片含量，干扰因素少，结论该法分离好，快速简便，可作为该产品的质量控制方法。     

创新药品抽验效能工作模式的思考

药品抽验是药品监督管理的重要组成部分.药品监督抽验工作水平的高低是衡量药监管理部门技术监督和稽查工作效果的重要指标,本文针对目前抽验工作的情况,对如何进一步增强药品监督抽验的科学性、方向性和有效性,提出对策.     

盐炙法在中药炮制中的药效学研究

盐炙法是传统的中药炮制方法,目前研究较多.文章对其药效学的研究进行了归纳总结.盐炙法可引药入肾,同时增强药物作用,如温肾壮阳、镇痛、缩尿、止泻、滋阴以及现代药理作用降糖、调节骨代谢等,还可减轻药物燥毒,使药物达到更好疗效.     

微侵袭神经外科的进展

传统神经外科手术创伤较大，有一定的危险性和并发症，对脑深部及高危险部位病变的治疗亦受到了限制，而微侵袭神经外科（Ｍｉｎｉｍａｌｌｙ　ｉｎｖａｓｉｖｅ　ｎｅａｒｏｓｕｒｇｅｒｙ）显示出美好而广阔的发展前景。１９９２年，德国学者Ｂａuｅｒ和Ｈｅｌｌｗｉｇ首先提出“微侵袭神经外科”的概念。随着神经影像学、微导管技术、立体定向技术、显微外科技术、激光技术、超声技术，放射医学，导航设备和计算机科学等的迅速发展，微侵袭神经外科取得了长足进步，现已成为极具活力的研究热点和发展方向。１ 显微神经外科（Ｍｉｃｒｏｎ…     

蜂螫疗法与五行

探讨了涉及蜂王、养蜂及神经传递等9种要素的蜂螫疗法。第一次提出了蜂蜇疗法与中医五行的关系,即蜂毒、蜂蜜、蜂胶、蜂王浆与花粉分别与火、土、金、水、木相配合,构成了蜂蜇疗法与五行的系统联系。结合现代研究及传统的时间治疗学,提出了蜂蜇疗法的最佳治疗时间及治疗特点。     

马桑内酯激活星形胶质细胞条件培养液对大脑皮质及海马神经元雌、孕激素受体的影响

BACKGROUND： Coriaria lactone-activated astrocytes released bioactive substances that eventually caused epilepsy.
OBJECTIVE： It has been suggested that activated astrocytes alter the expression of the estrogen receptor and progesterone receptor by releasing bioactive substances during epilepsy, thereby affecting neuronal activity in the brain. This study was designed to observe the expression of the estrogen receptor and the progesterone receptor in rat brain following lateral ventricle injection of coriaria lactone-activated, astrocyte-conditioned medium.
DESIGN AND SETTING： This immunohistochemical, randomized, controlled, animal study was conducted at the Department of Pathology, Hospital Affiliated to Binzhou Medical College, China.
MATERIAL： Coriaria lactone was provided by Huaxi Pharmaceutical Factory, China. METHODS： Forty adult, healthy, male, Sprague Dawley rats were randomly assigned into two groups. Astrocyte-conditioned medium （10 μ L） was injected into rat lateral ventricle in the control group （n = 8）. Coriaria lactone-activated, astrocyte-conditioned medium （10 μL） was infused into the rat lateral ventricle in the coriaria lactone group （n = 32）. At 2, 4, 8 and 12 hours following injection, rats were sacrificed and subjected to immunohistochemistry. Eight rats were studied at each time point.
MAIN OUTCOME MEASURES： Behavioral changes were observed in rats of both groups. Expression of the estrogen receptor and the progesterone receptor in rat cortical and hippocampal neurons was measured using immunohistochemistry.
RESULTS： Four hours after injection, estrogen receptor levels in rat cortical and hippocampal neurons were significantly higher in the coriaria lactone group than in the control group （P 〈 0.05）. Progesterone receptor levels were significantly lower in the coriaria lactone group than in the control group （P 〈 0.05）. Seizures were not observed in the control group. In the coriaria lactone group, convulsions appeared 30 minutes after injection; seizures reached grade Ⅲ at 45 minutes rat behavior was nearly normal at 2 hours.
CONCLUSION： Activated astrocytes can induce seizures in the rat by enhancing estrogen receptor expression and decreasing progesterone receptor expression in cerebral cortical and hippocampal neurons.     

冠心病患者介入术前后中医证候演变规律分析

目的 通过分析近30年相关文献,探讨冠心病介入术前后中医证候分布及演变.方法 检索中国知网近30年冠心病介入术前后证候研究的相关文献,提取文献信息,采用证候要素归纳冠心病患者介入术前后的证候特点.结果 共纳入文献22篇,涉及病例4211例.冠心病患者介入术前中医证候分布主要以血瘀证(33.33％)、气虚证(20.98％)、痰浊证(18.74％)为主;介入术后中医证候分布亦主要以血瘀证(28.48％)、气虚证(22.98％)、痰浊证(20.64％)为主.介入术前血瘀、气滞、寒凝、热蕴等实证明显多于介入术后(P＜0.01),而介入术后的气虚、阴虚、阳虚等虚证明显多于介入术前(P＜0.01).结论 冠心病患者介入术前后均以血瘀、痰浊和气虚证为主,但总体介入术后较介入术前有从实转虚趋势.