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大剂量化疗联合造血干细胞移植已成为治疗血液系统恶性肿瘤的重要方法之一。造血干细胞移植是对患者进行超大剂量放疗或化疗预处理后,将正常造血干细胞移植入患者体内,使其重建正常的造血以及免疫功能的治疗方法[1],使血液肿瘤患者获得较长生存期。但造血干细胞移植过程复杂,特别是在移植过程中,患者行预处理后免疫功能低下,极易引发各种相关并发症,加之整个造血干细胞移植过程均必须在无菌层流病房完成,患者因经受移植前化疗药物预处理带来的身体痛苦及长期与外界隔离而不能与亲朋直接接触,无法进行直接交流,易使患者出现较大的心理波动。因此,分析患者移植各阶段不同的心理问题及进行有效的心理护理,使患者树立信心,配合完成移植过程,对提高移植成功率和疾病康复有着重要意义。 相似文献
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目的:探讨疏肝解郁方联合三苯氧胺治疗乳腺癌的临床疗效及对血清肿瘤标志物水平的影响。方法:选取2012年6月—2014年11月本院收治的乳腺癌患者86例,随机分为对照组(n=43)及观察组(n=43),2组均行手术切除治疗,术后给予枸橼酸他莫昔芬片(三苯氧胺),观察组在此基础上给予疏肝解郁方辨证论治。统计2组近远期临床疗效及治疗期间的不良反应;比较2组治疗前后肿瘤标志物水平的变化。结果:观察组总有效率为62.79%,显著高于对照组的39.53%(P0.05),观察组治疗后1年、2年生存率显著高于对照组(P0.01);治疗期间观察组并发症发生率为27.91%,明显低于对照组的65.11%(P0.01)。治疗后观察组血清CEA、CA153及TSGF水平均低于治疗前与对照组(P0.01)。结论:中西医结合治疗乳腺癌效果显著,可提高患者临床疗效及远期生存率,安全性好,且一定程度降低了相关肿瘤标志物的水平。 相似文献
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目的:评价真实世界中中医扶正固摄法对非小细胞肺癌(NSCLC)患者远期生存的影响。方法:采用回顾性队列研究,收集北京中医药大学东直门医院2014年1月至2018年12月以扶正固摄法治疗为主的NSCLC患者作为中西医结合队列,下载美国国立癌症研究所(SEER)数据库中2011年1月至2015年12月的NSCLC数据作为西医队列,采用倾向性评分匹配法(PSM)平衡组间混杂因素,获得可比的两队列样本,进一步采用Log-rank检验法比较组间总生存差异,同时根据不同临床特征进行分层生存分析,并绘制生存曲线。结果:中西医结合队列获得511例NSCLC患者,西医队列收集得到5 022例NSCLC患者,两队列基本临床特征比较发现,组间年龄、性别和化疗情况差异无统计学意义,但在病理类型、淋巴结转移情况(N)、远处转移情况(M)、手术和放疗方面均存在明显差异(P<0.05)。采用PSM方法根据样本倾向评分进行组间匹配,经PSM匹配获得122例组间均衡的样本,总体生存分析显示,中西医结合队列的总生存优于西医队列(P<0.05)。分层生存分析发现中西医结合队列在女性、男性、低龄、腺癌、N+和M+... 相似文献
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BackgroundThe network meta-analysis system was used to evaluate the efficacy of various acupuncture and moxibustion techniques for chronic rhinosinusitis (CRS) and related postoperative pain.MethodsAn electronic search of PubMed, Embase, Web of Science, Cochrane Library, OVID(the Offshore Vessel Inspection Database), CNKI, Wanfang, VIP, and CBM databases was conducted to identify randomised controlled trials on acupuncture and moxibustion for CRS and related postoperative pain from database inception to February 2021.The study included randomised controlled trials (RCTs) published in China and other countries in languages limited to Chinese and English. Primary studies included treated individuals without limitations on age, gender, or nationality and diagnosed as CRS. The total effective rate, visual analogue scale (VAS) score, and symptom and sign score were the primary outcomes. Evidence quality and risk-of-bias were determined. Network meta-analysis was performed.ResultsNineteen articles were included, involving 11 types of intervention measures. The pairwise comparisons showed that both acupuncture therapy combined with drugs (ATD) and sphenopalatine ganglion acupuncture combined with drugs (SGAD) were superior to western medicine (WM) in improving the total effective rate, and ATD was superior to manual acupuncture therapy (MAT), WM, and placebo (PL). In reducing the VAS score, both ATD and SGAD were superior to WM. Point-through-point acupuncture combined with pricking blood therapy (PABT) was superior to MAT. In reducing symptom and sign score, ATD was superior to WM and PL. PABT was superior to MAT. The results of network meta-analysis showed that ATD was superior to MAT, Traditional Chinese medicine (TCM), and WM in improving the total effective rate. In reducing the symptom and sign score, ATD was superior to PL, WM, MAT, and sham acupuncture (SA). PL was superior to MAT, WM, and SA. and PABT was superior to MAT and SA, MAT was superior to WM. There was no significant difference between the intervention measures in reducing the VAS score. The surface under the cumulative ranking curve showed that ATD had the best effect in improving the total effective rate and reducing the VAS and symptom and sign score.ConclusionATD was the best method for improving the total effective rate and reducing the VAS and symptom and sign score in the treatment of CRS and related postoperative pain. However, considering the current study quantity and quality, multicentre and high-quality clinical studies with larger sample sizes are needed to verify our findings.Trial registrationInternational Prospective Register of Systematic Reviews(CRD42021246103). 相似文献
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