乙酰肉碱及肉碱对实验性心力衰竭的影响

Acart和cart对犬或兔由戊巴比妥所致的急性衰竭心脏均有明显的正性变力,血管扩张和负性变速作用。在心衰犬,静注acart或cart后,再给stro-k均可使其诱发心律失常及致死量明显提高(p<0.05),安全范围增大。当acart或cart与stro-k以较小剂量合用于心衰兔时,二者产生协同强心作用。而且,acart不论单用,或与stro-k合用,其强心作用均比cart强。     

活脉散的药理研究

活脉散灌胃一天两次,共5天后,能显著延长血栓形成时间,抑制ADP和胶原诱导血小板聚集,同时降低全血粘度,但对红细胞压积无明显影响。结果表明,活脉散对血液系统具有多方面药理作用。     

乙酰肉碱及肉碱对实验性心力衰竭的影响

Acart和cart对犬或兔由戊巴比妥所致的急性衰竭心脏均有明显的正性变力,血管扩张和负性变速作用。在心衰犬,静注acart或cart后,再给stro-k均可使其诱发心律失常及致死量明显提高(p<0.05),安全范围增大。当acart或cart与stro-k以较小剂量合用于心衰兔时,二者产生协同强心作用。而且,acart不论单用,或与stro-k合用,其强心作用均比cart强。     

甲基黄酮醇胺盐酸盐对β受体的阻断作用

The β-receptor blocking action of methylflavonolamine hydrochloride(MFA) was studied and compared with those of propranolol. The doseresponse curves of isoproterenol were shifted to the right by MFA on isolated rabbit atrium in this experiment. The pA₂ value and the slope of the regression line of MFA calculated from Schild plot were 5.53 and -0.84 respectively. The effects of MFA and propranolol on duck erythrocyte membranes were studied by the radioligand binding method. Both MFA and propranolol inhibited the binding of [³H] dihydroalprenolol to β-receptors. Their apparent equilibrium dissociation constants were 1.12×10^-5 mol/L and 5.50×10^-9 mol/L respectively. The affinity of propranolol to β-receptors of duck erythrocyte membranes was 2039-fold higher than that of MFA. These results demonstrates that MFA is a weak competitive β-receptor blocking agent.     

国产室安卡因抗心律失常作用的实验研究

<正> 室安卡因(Tocainide,W36095) 是近年来国外新研制的抗心律失常药物,其化学结构与利多卡因相似,为其同系物,化学名为d-氨基丙酰-2′,6′-二甲基苯胺(d-amino-2′,6′-propionoxy lidide)。     

甲基黄酮醇胺盐酸盐对β受体的阻断作用

甲基黄酮醇胺盐酸盐(methylflavonolamine hydrochloride,MFA),化学名4′-甲基-7-(2-羟-3-异丙胺基丙氧基)黄酮盐酸盐,其分子结构上具有心得安的活性基团。