Key principles for user-centred systems design

The concept of user-centred systems design (UCSD) has no agreed upon definition. Consequently, there is a great variety in the ways it is applied, which may lead to poor quality and poor usability in the resulting systems, as well as misconceptions about the effectiveness of UCSD. The purpose of this paper is to propose a definition of UCSD. We have identified 12 key principles for the adoption of a user-centred development process, principles that are based on existing theory, as well as research in and experiences from a large number of software development projects. The initial set of principles were applied and evaluated in a case study and modified accordingly. These principles can be used to communicate the nature of UCSD, evaluate a development process or develop systems development processes that support a user-centred approach. We also suggest activity lists and some tools for applying UCSD.     

Integrating Ecological,Social and Cultural Dimensions in the Implementation of the Landscape Convention

Implementation of the European Landscape Convention requires new tools that link ecological, social and cultural dimensions in practical planning. Here, we propose connectivity as a conceptual tool to include different dimensions into landscape and spatial planning. We present a short review of the connectivity concept in relation to ecological, social and cultural dimensions and illustrate it by examples from a real landscape planning case.     

Large scale integration of wind power: moderating thermal power plant cycling

Power plant cycling in thermal plants typically implies high costs and emissions. It is, therefore, important to find ways to reduce the influence of variations in wind power generation on these plants without forsaking large amounts of wind power. Using a unit commitment model, this work investigates the possibility to reduce variations by means of a moderator, such as a storage unit or import/export capacity. The relation between the reduction in CO₂‐emissions and the power rating of the moderator is investigated, as well as the benefit of a moderator which handles weekly variations compared with a moderator which has to be balanced on a daily basis. It is found that a daily balanced moderator yields a decrease in emissions of about 2% at 20% wind power grid penetration. The reduction in emissions is mainly due to an avoidance of start‐up and part load emissions and a moderator of modest power rating is sufficient to achieve most of this decrease. In the case of a weekly balanced moderator, emissions are reduced as the moderator power rating increases. At 40% wind power grid penetration, a weekly balanced moderator reduces emissions with up to 11%. The major part of this reduction is due to the avoidance of wind power curtailment. The simulated benefit (CO₂‐emissions and costs) from adding a general moderator is compared with emissions from Life Cycle Assessment (LCA) studies and cost data of five available moderator technologies; transmission capacity, pumped hydro power, compressed air energy storage, flow batteries and sodium sulphur batteries. Copyright © 2010 John Wiley & Sons, Ltd.     

Regeneration of defects in articular cartilage with callus and cortical bone grafts. An experimental study

Luteal-phase estrogen and progesterone concentrations were measured every other day and used to monitor the corpus luteum activity. The patterns of estrogen and progesterone concentrations were compared relative to the day of endogenous human chorionic gonadotropin (hCG) detection (defined as the day of implantation). The relationship between estrogen and progesterone and hCG concentrations was studied in 71 viable pregnancies, 12 clinical abortions, five preclinical abortions and 84 non-pregnant cycles after IVF/ET. Although all patients received luteal-phase progesterone support (25-50 mg/ml), low late luteal-phase progesterone concentrations of < 30 ng/ml from day + 11 to day + 15 were found in 64 patients (17% of viable pregnancies, 33.3% of clinical abortions, 60% of preclinical abortions and 53.6% of non-pregnant cycles) day + 1 was the day of retrieval). Implantation always occurred before or on day + 13 and 86% of pregnant cycles implanted on day + 8 to day + 11. Viable pregnancies had significantly higher mean progesterone concentrations on day + 3 to day + 7 (pre-implantation) and on day + 9 to day + 15 (postimplantation) than those of non-pregnant cycles or abortions. On the day of implantation, the mean +/- standard of deviation of estrogen (pg/ml) and progesterone (ng/ml) levels for viable pregnancies, clinical abortion and preclinical abortions were 314 +/- 210, 40.5 +/- 25; 226.7 +/- 246, 48.7 +/- 31; and 39.6 +/- 24.5, 28.6 +/- 24.5, respectively. On the same day, 73.2% of viable pregnancies, 41.7% of clinical abortions, and 20% preclinical abortions had a progesterone concentration > 30 ng/ml; 73.2% of viable pregnancies, 41.7% of clinical abortions and 20% of preclinical abortions had an estrogen concentration > 100 pg/ml. Although not precluding implantation completely, late luteal-phase hormonal deficiencies may impair endometrial growth and might ultimately lead to failure or abnormal implantation. A viable pregnancy requires not only a functional corpus luteum in the early luteal phase to develop a receptive endometrium, but also a responsive corpus luteum in the late luteal phase to support pregnancy. The time of implantation is critical. Implantation that occurs before the demise of the corpus luteum will facilitate a normal pregnancy.     

An adaptive strategy for the bivariate solution of finite element problems using multivariate nested Padé approximants

Most engineering applications involving solutions by numerical methods are dependent on several parameters, whose impact on the solution may significantly vary from one to the other. At times an evaluation of these multivariate solutions may be required at the expense of a prohibitively high computational cost. In the present paper, an adaptive approach is proposed as a way to estimate the solution of such multivariate finite element problems. It is based upon the integration of so‐called nested Padé approximants within the finite element procedure. This procedure includes an effective control of the approximation error, which enables adaptive refinements of the converged intervals upon reconstruction of the solution. The main advantages lie in a potential reduction of the computational effort and the fact that the level of a priori knowledge required about the solution in order to have an accurate, efficient, and well‐sampled estimate of the solution is low. The approach is introduced for bivariate problems, for which it is validated on elasto‐poro‐acoustic problems of both academic and more industrial scale. It is argued that the methodology in general holds for more than two variables, and a discussion is opened about the truncation refinements required in order to generalize the results accordingly. Copyright © 2014 John Wiley & Sons, Ltd.     

Aflatoxin formation in hay treated with formic acid and in isolated strains of Aspergillus flavus

The possibility of improving the keeping qualities of field-dried and hayloft-dried hay, with dry matter contents of 55 and 73% by adding sodium chloride, formic acid and propionic acid was investigated. Field-dried, sodium-chloride-treated hay was stored in containers, while controls and acid-treated hay were pressed into high-density bales. All hayloft-dried hay was stored in containers. Fungal attacks were very heavy, especially in the baled hay. The contaminating flora was examined at the temperature maximum and after 40 and 32 days storage for field-dried and hayloft-dried hay respectively. The genera Penicillium, Cladosporium and Trichothecium were predominant in hayloft-dried hay, and the differences between varying dry matter contents were insignificant. Mostly Aspergillus spp., but also Penicillium spp., occurred in the field-dried hay at 73% dry matter content but at 55% the flora consisted mostly of Aspergillus flavus, and the formic acid-treated hay contained almost a pure culture of this fungus. In addition, aflatoxin B₁ and G₁ (635–1000 μg/l) were demonstrated in this formic acid-treated hay.

Toxin formation in isolates of A. flavus from differently treated hay specimens was also investigated on various substrates.     

The cyclotide fingerprint in oldenlandia affinis: elucidation of chemically modified, linear and novel macrocyclic peptides

The complete suite of cyclotides present in Oldenlandia affinis (Rubiaceae), the plant that was originally found to contain this unique family of circular proteins, has been characterised. This study expands the number of known cyclotides in this plant to 17, of which nine new sequences (kalata B9-B17) were characterised in this work. In addition, five derivatives that contain oxidation products of the conserved tryptophan were identified, and it was shown that the formation of these derivatives is catalysed by exposure to sunlight. Furthermore, we describe two "linear" cyclotide analogues. These acyclic peptides have three intact disulfide bonds, and their N and C termini coincide with the hypothesised cleavage sites from the precursor protein. This work increases our knowledge about the sequence variation that is accommodated by the cyclic cystine knot scaffold, confirms its applicability as a template for drug design, and also shows the first natural degradation pathways for cyclotides. These pathways have important implications for the persistence and environmental fate of the cyclotides if used as crop-protection agents.     

Towards a mature offshore wind energy technology—guidelines from the opti‐OWECS project

The article reviews the main results of the recent European research project Opti‐OWECS (‘Structural and Economic Optimisation of Bottom‐Mounted Offshore Wind Energy Converters'), which has significantly improved the understanding of the requirements for a large‐scale utilization of offshore wind energy. An integrated design approach was demonstrated for a 300 MW offshore wind farm at a demanding North Sea site. Several viable solutions were obtained and one was elaborated to include the design of all major components. Simultaneous structural and economic optimization took place during the different design stages. An offshore wind energy converter founded on a soft–soft monopile was tailored with respect to the distinct characteristics of dynamic wind and wave loading. The operation and maintenance behaviour of the wind farm was analysed by Monte Carlo simulations. With an optimized maintenance strategy and suitable hardware a high availability was achieved. Based upon the experience from the structural design, cost models for offshore wind farms were developed and linked to a European database of the offshore wind energy potential. This enabled the first consistent estimate of cost of offshore wind energy for entire European regions. Copyright © 1999 John Wiley & Sons, Ltd.     

Plug-in hybrid electric vehicles as regulating power providers: Case studies of Sweden and Germany

This study investigates plug-in hybrid electric vehicles (PHEVs) as providers of regulating power in the form of primary, secondary and tertiary frequency control. Previous studies have shown that PHEVs could generate substantial profits while providing ancillary services. This study investigates under what conditions PHEVs can generate revenues using actual market data, i.e. prices and activations of regulating power, from Sweden and Germany from four months in 2008. PHEV market participation is modelled for individual vehicles in a fleet subject to a simulated movement pattern. Costs for infrastructure and vehicle-to-grid equipment are not included in the analysis. The simulation results indicate that maximum average profits generated on the German markets are in the range 30–80 € per vehicle and month whereas the Swedish regulating power markets give no profit.