Low-contrast lesion segmentation in advanced MRI experiments by time-domain Ricker-type wavelets and fuzzy 2-means

Automated suspicious region segmentation has become a crucial need for the experts dealing with numerous images containing contrast-based lesions in MRI. Not all solutions, however, are based on mathematical infrastructure or providing adequate flexibility. On the other hand, segmentation of low-contrast lesions is very challenging for researchers; therefore, advanced magnetic resonance imaging (MRI) experiments are not commonly used in researches. Given the need of repeatability and adaptability, we present an automated framework for intelligent segmentation of brain lesions by wavelet imaging and fuzzy 2-means. Besides the general use of the wavelets in image processing, which is edge detection; we employed the second-order Ricker-type wavelets as the core of our novel imaging framework for low-contrast lesion segmentation. We firstly introduced the mathematical basis of several Ricker wavelet functions, which are in symmetrical form satisfying finite-energy and admissibility conditions of mother wavelets. Afterwards, we investigated three types of Ricker wavelets to apply on our clinical dataset containing susceptibility-weighted (SW) and minimum intensity projection SW (mIP-SW) images with barely-visible lesions. Finally, we adjusted the system parameters of the wavelets for optimization and post-segmentation by fuzzy 2-means. According to the preliminary results of the clinical experiments we conducted, our framework provided 93.53% average dice score (DSC) for SWI by Ricker-3 and 92.56% for mIP-SWI by Ricker-2 wavelet, as the main performance criteria of segmentation. Despite the lack of SWI or mIP-SWI experiments in the public datasets, we tested our framework with BraTS 2012 training sets containing real images with visible lesions and achieved an average of 88.13% DSC with 11.66% standard deviation by re-optimized framework for whole lesion segmentation, which is one of the highest among other relevant researches. In detail, 87.52% DSC for LG datasets with 11.32% standard deviation; while 88.34% DSC for HG datasets with 11.77% standard deviation are calculated.

     

Porous heat exchangers for continuous flow helium cryostats

An investigation was made into the effective application of porous heat exchangers of cylindrical shape through which fluid passes axially. On the basis of a theoretical analysis the conclusion derived was that the best thermal efficiency can be reached by the use of porous material with a large heat-exchanger surface, a high radial and low axial thermal conductivity (ie with a marked anisotropy of thermal conductivity), and a small radius of the heat exchanger operating at lower flows of cooling agent. The results of experiments carried out at helium and nitrogen temperatures are presented. These results have confirmed the high effectiveness of porous heat exchangers, even in comparison with chamber-type heat exchangers. For the temperature range from 1.5 to 300 K the heat exchangers composed of highly conductive metal nets (mesh gauge of the order of magnitude of 10^?1 mm) stacked perpendicularly to the direction of flow of the cooling fluid, appear to be the most promising ones.     

Method of determination of the effective capacity of refrigeration and A/C units of variable speeds

A new evaluation method of transport refrigeration and A/C units is presented. This method allows the overall cooling performance during truck or bus operation, with respect to different engine speeds and driving styles, to be taken into account. The use of this method is demonstrated in the evaluation of two refrigeration units.     

The use of the setchkin apparatus—mass spectrometry in the investigation of ignition and burning of flame retarded polystyrenes

A review is given of the possibilities for the use of the Setchkin apparatus combined with mass spectrometry in the investigation of the gaseous products of the thermo-oxidative decomposition and burning of flame-retarded polystyrenes, with simultaneous determination of the characteristics of ignition. Information on flame-retardants in polystyrene, and their effect on the inhibition of burning in the gaseous phase were provided by mass fragmentation analysis of the main components of decomposition and burning.     

Epithelial-myoepithelial carcinoma of the bronchus

An extremely rare case of epithelial-myoepithelial carcinoma (EMC) of a lobar bronchus in a 47-year-old female is reported. Grossly, the tumor formed a polypoid mass obstructing the bronchial lumen. Microscopically, it was composed of two cellular types--epithelial cells with eosinophilic cytoplasm and clear myoepithelial cells. Numerous tubules formed by an inner epithelial and outer myoepithelial layer were found. Focally, the tumor showed solid growth of clear cells. Prominent hyalinization of the stroma was found. The nature of the cells was confirmed by positive expression of cytokeratins and epithelial membrane antigen in epithelial cells and vimentin and smooth muscle actin in myoepithelial cells. Differential diagnosis of EMC includes a broad spectrum of salivary gland-type tumors. Furthermore, metastases of clear cell carcinoma of the kidney or thyroid, clear cell ("sugar") tumor of the lung, glandular form of carcinoid, bronchioalveolar adenocarcinoma with myoepithelial cells and pulmonary adenosquamous carcinoma with amyloid-like stroma must be distinguished from EMC. The tumor has neither recurred nor metastasised, a fact supporting the current opinion, that EMC is a tumor of low grade malignancy.     

Intrathyroidal lymphoepithelial cyst. A report of two cases not associated with Hashimoto's thyroiditis

Two cases of intrathyroidal lymphoepithelial cyst are described. Both of them were solitary, one being found incidentally in a patient operated on for a multinodular goiter, the other being clinically obvious as a cold nodule. They exhibited features of cysts of branchial cleft origin, i.e. squamous cell lining epithelium and abundant lymphoid tissue with reactive germinal centers. The thyroid gland parenchyma showed a discrete lymphoid infiltration consistent with the diagnosis of focal lymphocytic thyroiditis. In the first case a single epidermoid solid cell nest was found. The histogenesis of intrathyroidal lymphoepithelial cysts remains unclear, but their origin from cystically degenerated ultimobranchial body remnants (solid cell nests) seems to be most probable. This assumption is supported by a similar immunohistochemical profile of solid cell nests and epithelial cells lining the cysts and also by the presence of one solid cell nest in the proximity to the cyst in one of our cases.