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Radosław Michalski Tomasz Kajdanowicz Piotr Bródka Przemysław Kazienko 《New Generation Computing》2014,32(3-4):213-235
The problem of finding optimal set of users for influencing others in the social network has been widely studied. Because it is NP-hard, some heuristics were proposed to find sub-optimal solutions. Still, one of the commonly used assumption is the one that seeds are chosen on the static network, not the dynamic one. This static approach is in fact far from the real-world networks, where new nodes may appear and old ones dynamically disappear in course of time. The main purpose of this paper is to analyse how the results of one of the typical models for spread of influence - linear threshold - differ depending on the strategy of building the social network used later for choosing seeds. To show the impact of network creation strategy on the final number of influenced nodes - outcome of spread of influence, the results for three approaches were studied: one static and two temporal with different granularities, i.e. various number of time windows. Social networks for each time window encapsulated dynamic changes in the network structure. Calculation of various node structural measures like degree or betweenness respected these changes by means of forgetting mechanism - more recent data had greater influence on node measure values. These measures were, in turn, used for node ranking and their selection for seeding. All concepts were applied to experimental verification on five real datasets. The results revealed that temporal approach is always better than static and the higher granularity in the temporal social network while seeding, the more finally influenced nodes. Additionally, outdegree measure with exponential forgetting typically outperformed other time-dependent structural measures, if used for seed candidate ranking. 相似文献
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Caroline Fauquant Valrie Briard Nadine Leconte Marie‐Caroline Michalski 《European Journal of Lipid Science and Technology》2005,107(2):80-86
The aim of this study was to characterize the fatty acid composition of the core and membrane of differently sized milk fat globules separated by microfiltration, which can now be used to manufacture dairy products. Native milk fat globules of various mean diameters, ranging from d43 = 2.3 µm to 8.0 µm, were obtained using microfiltration of raw whole milk. After milk fat globule washing, the milk fat globule membrane (MFGM) and the triglyceride core (TC) were separated by manual churning. After total lipid extraction from each fraction, their fatty acid composition was characterized using methyl ester analysis by gas chromatography. Regardless of season, no significant differences were observed in the fatty acid composition of the MFGM phospholipids. Conversely, significant differences were found in the fatty acid composition of TC; particularly, small fat globule TC contained more medium‐chain fatty acids and less stearic acid than large fat globule TC. These results show that the previously observed differences in total fatty acid composition among differently sized milk fat globules are due to their triglyceride composition and MFGM amount rather than to the composition of the MFGM. 相似文献
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Michael?J.?HaasEmail author Paul?J.?Michalski Stan?Runyon Alberto?Nunez Karen?M.?Scott 《Journal of the American Oil Chemists' Society》2003,80(1):97-102
Simple alkyl FA esters have numerous uses, including serving as biodiesel, a fuel for compression ignition (diesel) engines.
The use of acid-catalyzed esterification for the synthesis of FAME from acid oil, a by-product of edible vegetable oil refining
that is produced from soapstock, was investigated. Soybean acid oil contained 59.3 wt% FFA, 28.0 wt% TAG, 4.4 wt% DAG, and
less than 1% MAG. Maximum esterification occurred at 65°C and 26 h reaction at a molar ratio of total FA/methanol/sulfuric
acid of 1∶15∶1.5. Residual unreacted species under these conditions, as a fraction of their content in unesterified acid oil,
were FFA, 6.6%; TAG, 5.8%; and DAG, 2.6%. This corresponds to estimated concentrations of FFA, 3.2%; TAG, 1.3%; and DAG, 0.2%,
on a mass basis, in the ester product. In an alternative approach, the acylglycerol species in soapstock were saponified prior
to acidulation. High-acid (HA) acid oil made from this saponified soapstock had an FFA content of 96.2 wt% and no detectable
TAG, DAG, or MAG. Optimal esterification conditions for HA acid oil at 65°C were a mole ratio of FFA/methanol/acid of 1∶1.8∶0.17,
and 14 h incubation. FAME recovery under these conditions was 89% of theoretical, and the residual unesterified FFA content
was approximately 20 mg/g. This was reduced to 3.5 mg/g, below the maximum FFA level allowed for biodiesel, by washing with
NaCl, NaHCO3, and Ca(OH)2 solutions. Alternatively, by subjecting the unwashed ester layer to a second esterification, the FFA level was reduced to
less than 2 mg/g. The acid value of this material exceeded the maximum allowed for biodiesel, but was reduced to an acceptable
value by a brief wash with 0.5 N NaOH. 相似文献
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A simple method for the isolation of hematoside NeuNG1-Lac-Cer from horse erythrocytes is described. An aliquot of the crude
ganglioside fraction was labeled by tritiated sodium borohydride after mild periodate oxidation. The compounds obtained were
used as radioactive tracers in column chromatography. Gangliosides were applied onto a silicic acid column and eluted stepwise
by solvents of steadily increasing polarity. The major ganglioside, NeuNG1-Lac-Cer, was eluted in a high yield by the solvent
mixture chloroform/methanol/water (60∶35∶8, v/v/v). 相似文献
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ML Jensen OM Jensen W Michalski OS Nielsen J Keller 《Canadian Metallurgical Quarterly》1996,23(5):458-463
Superficial leiomyosarcomas are rare tumours. The lesions confined to the dermis, contrary to those involving the subcutis, have been reported to carry a favourable prognosis. A retrospective study of 41 consecutive cases of surgically treated intradermal and subcutaneous leiomyosarcomas was undertaken in order to determine the prognostic factors that may influence the survival of these patients. Seven tumours were predominantly intradermal and 34 involved the subcutaneous tissue. Fifty-four percent of the tumours were located in the lower extremities. All cases stained positively for smooth muscle antigen and 66% for desmin. The tumours were classified with regard to tumour grade I (low grade, 3%), II (intermediate, 12%), IIIA (high grade, 46%) and IIIB (high grade, 39%). In all patients, follow-up information was available. Mean follow-up time was 5 years. The patients with intradermal tumours were all alive without signs of recurrence, whereas 14 of those with leiomyosarcomas involving the subcutis have died with pulmonary metastases. Our study confirms that "pure" intradermal leiomyosarcomas independent of tumour grade behave in a benign fashion, probably due to small tumour size. Tumour size > or = 5 cm, deep localization with fascia involvement, and high malignancy grade (IIIB) were found to deteriorate survival based on a univariate analysis. However, in a multivariate analysis only tumour size was found to be an independent prognostic factor. 相似文献
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Glycoproteinoses, Pompe disease, and sialic acid storage diseases are characterized by a massive accumulation of unprocessed oligosaccharides and/or glycoconjugates in urine. The identification of these glycocompounds is essential for a proper diagnosis. In this study, we investigated the potential of MALDI‐TOF‐MS to identify glycocompounds present in urine from patients with different inborn errors of glycan metabolism. Urinary glycocompounds were permethylated, and analyzed using GC‐MS and MALDI‐TOF‐MS. In order to confirm tentative assignments, a second aliquot of urine was purified on a C18 Sep‐Pak cartridge and glycocompounds were desalted on a column of nonporous graphitized carbon. The glycocompounds were then sequentially on‐plate digested using an array of exoglycosidases. A range of disease‐specific oligosaccharides as well as glycopeptides was identified for all oligosacchariduria models. In addition, free sialic acid accumulated in urine from a patient suffering from French‐type sialuria, has been detected by a GC‐MS approach, which could be applied to other sialic acid storage diseases. This procedure is simple, and can be performed in few simple steps in less than 24 h. This current method can be applied for newborn screening for other inherited metabolic diseases as well as for assessing treatments in clinical trials. 相似文献
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