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1.
GS Kelner JM Minnerath MK Jenkins R Jemmerson 《Canadian Metallurgical Quarterly》1993,23(8):1992-1998
Male and female A/J mice were examined for their ability to elicit T lymphocyte and antibody (Ab) responses to the male-specific Ag, mouse testicular cytochrome c (Mt cyt). T lymphocytes from both male and female mice primed in vivo responded to the Ag in in vitro proliferation assays, and the dose-response curves were statistically indistinguishable. In addition, similar levels of Ab to Mt cyt were observed in immunized male and female mice. The B cells producing the Ab had switched isotypes to IgG1 and IgG2a, indicating that the self-reactive T helper (Th) cells in male mice were functional. Thus, male mice do not appear to be immunologically tolerant to Mt cyt, at least at the Th and B lymphocyte levels. No evidence for disease was found in male mice primed with Mt cyt. Major histocompatibility complex (MHC) class II-positive antigen-presenting cells are present in the testes and these were shown in vitro to process and present Mt cyt to a T cell hybridoma specific for the synthetic peptide Mt cyt 93-104. However, the hybridoma was not activated in the absence of exogenous Mt cyt 93-104 or Mt cyt, indicating that endogenous Mt cyt is not normally processed in sufficient quantity to effectively load MHC class II molecules with this particular Mt cyt-derived peptide. Notwithstanding any immunologic privilege of the testes, the lack of tolerance to Mt cyt and its failure to elicit an autoimmune disease could extend from the low levels of processed Mt cyt Ag available for T cell recognition. The T cell response elicited by Mt cyt contrasts the lack of response to mouse somatic cytochrome c which differs from Mt cyt at 13 amino acid residues and is expressed in most tissues and at higher levels. 相似文献
2.
Qin‐Tao Liu Malcolm R Clench Judith L Kinderlerer 《Journal of the science of food and agriculture》2002,82(5):553-558
Structural isomers of monoacylglycerols (monoglycerides, MAGs) were identified and compared after degradation of butter oil by two strains of Penicillium roquefortii and a commercial lipase from P roquefortii (EC 3.1.1.3) at pH 7.0 and 10 °C. The conditions were selected as they were comparable with those used in the manufacture of blue mould‐ripened cheese. The commercial lipase was selected to compare with the fungal strains in terms of acyl migration. Results showed that the main isomers formed by lipolysis with the commercial lipase were sn‐2 MAGs (64 mol%), whilst spores and emerging mycelia of P roquefortii produced mainly sn‐1(3) MAGs (83–90 mol%). The work reported here may lead to further assessment of different MAG structural isomers as natural preservatives in foods and dairy products. © 2002 Society of Chemical Industry 相似文献
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Collected ratings of communication ease and of engagement for 95 deaf junior and senior high school students (aged 12–21 yrs) in a large, urban, multiethnic school for the deaf. Ratings were made by the students' English teachers and by the students themselves. High teacher ratings for communication ease and engagement were associated with high academic achievement as measured by the Stanford Achievement Test. High student ratings for communication ease were also associated with academic achievement. The 2 best predictors of academic achievement were student-rated communication ease and teacher-rated engagement. Findings suggest that it is important for teachers to be sensitive to the level of communication comfort of their students because students who enjoy easier communication may be more likely to be engaged, or more actively involved, in classroom learning and to demonstrate higher academic achievement. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
5.
Comments on the assertion of K. S. Pope (see record 83-37387) that the confirmation that supposedly validates claims about the false memory syndrome, its antecedents, and its rampant magnitude needs to be made available and carefully examined. The author considers why there has been acceptance of unsubstantiated claims of false memory, and also points to essential responsibilities for psychologists whose clients have abuse memories. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
6.
Judith Wusteman 《Expert Systems》1992,9(3):139-148
Abstract: This paper describes the use of the explanation-based learning (EBL) machine learning technique in the practical domain of knowledge acquisition for expert systems. A knowledge acquisition tool, EBKAT (Explanation-Based Knowledge Acquisition Tool), is described, which may be used in the development of knowledge bases for diagnostic expert systems. The functioning of EBKAT attempts to combine the full potential of a domain expert's skills and the power of explanation-based machine learning techniques. The EBL component is not employed in the acquisition of the knowledge base rules but is used to justify the knowledge entered and to relate it to the knowledge already in the system. It is suggested that the EBKAT tool goes some way towards overcoming the knowledge acquisition bottleneck and results in the acquisition of knowledge which is rich in contextual information. 相似文献
7.
An impassioned debate over the virtues and dangers of dieting is polarizing the field and diverts attention from key issues. Dieting clearly has costs and, for some, has the potential for benefit. The primary challenges are (1) to identify individuals who will be helped or harmed by dieting, (2) to reduce the frequency and severity of dieting in those for whom the costs exceed the benefits, (3) to better understand the physiological and psychological reasons why some people can lose and others cannot, and (4) to develop safe and effective means for weight loss and its maintenance and to target these methods to individuals who stand to benefit. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
8.
Although multidisciplinary pain programs have been demonstrated to be effective, the processes of improvement have yet to be clarified. Cognitive-behavioral models posit that improvement is due, in part, to changes in patient pain beliefs and coping strategies. To test the relationships between treatment outcome and changes in beliefs and coping strategies, 94 chronic pain patients (aged 21–64 yrs) completed measures of physical and psychological functioning, health care utilization, pain beliefs, and use of pain coping strategies at admission and 3 to 6 mo after inpatient pain treatment. Improved functioning and decreased health care use were associated with changes in both beliefs and cognitive coping strategies. However, changes in some coping strategies, such as exercise and use of rest, were not associated with improvement. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
9.
Emerson Judith; Bertoch Michael R.; Checketts Keith T. 《Canadian Metallurgical Quarterly》1994,31(1):109
Explored the construct validity of transactional analysis (TA) ego state concepts. Ego states are defined as coherent systems of thoughts, feelings, and behaviors. 65 university students seeking therapy and 95 university students not receiving therapy completed the Adjective Checklist (ACL) and the Brief Symptom Inventory (BSI). Ego state scores from the ACL correlated with BSI psychological distress in predicted directions. Four of the 5 TA ego state scores differentiated Ss seeking therapy from Ss not seeking therapy. Furthermore, ego state scores changed over the course of therapy, indicating a reduction of distress. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
Microstructure and mechanical properties of Pb-free solder alloys for low-cost electronic assembly: A review 总被引:5,自引:0,他引:5
Judith Glazer 《Journal of Electronic Materials》1994,23(8):693-700
Lead-free solders, including Sn-58Bi, Sn-52In, and Sn-3.5Ag, are potential replacements for Sn-37Pb solder in low-cost electronic
assembly. This paper reviews the literature on the microstructure and mechanical properties of these alloys. Because of the
processing and testing conditions, many of the data are not predictive for electronic assembly applications. However, eutectic
Sn-Bi seems to have properties approaching those of eutectic Sn-Pb under most conditions, while eutectic Sn-In seems far inferior
in most respects. Eutectic Sn-Ag has many promising characteristics, but its relatively high melting temperature may preclude
its use for this type of application. 相似文献