Calretinin in the cat retina: colocalizations with other calcium-binding proteins, GABA and glycine

Regeneration of skeletal muscle was studied in the sea bream Sparus aurata, in which extensive post-larval muscle hyperplasia contributes to its large adult size, and in the zebrafish Brachydanio rerio, which shows little post-larval hyperplasia and reaches only a small adult size. Small mechanical lesions of body wall muscle were made under general anaesthesia, and the progress of subsequent regeneration was assessed at various intervals by histology and electron microscopy (for general morphology), by immunostaining for desmin and myosin isoforms (to identify the phenotype of new fibres), and by 5'-bromo-2'-deoxyuridine (BrdU) incorporation (to identify proliferating cells). Despite the difference in normal growth-related hyperplasia in these fish, a vigorous regeneration occurred in both species, giving rise to new fibres with an initial myosin composition that differed from that in mature fast-white fibres. However, species differences in myosin expression in these fibres suggest that they may have derived from different myoblast populations. In sea bream, myosin expression in regenerating fibres resembled that seen in new fibres produced in post-larval white muscle, whereas in the zebrafish it resembled that of the primitive monolayer fibres formed during embryonic development. Subsequently, most regenerating fibres gradually transformed into the mature fast-white phenotype in both species.     

Power combining characteristics of backed-off traveling wave tubes for communications applications

Traveling wave tubes (TWTs) used in multi-tone and digital communications applications are typically operated backed off from saturation in order to improve the amplifier linearity. This reduces the bit error rate (BER), decreases intermodulation distortion and lowers adjacent channel power; all at the expense of reducing the average output power. For emerging telecommunications applications, the average power requirement is increasing to provide higher bit rates and lower BER, and often exceeds the power obtainable from backed-off space or telecommunications TWTs. One solution is to power combine TWTs that are operated 3 to 10 dB backed off from saturation. Efficient power combining requires that the phase and gain of the signal from each TWT be closely matched. To understand the variation in these parameters across a build-set of tubes, the phase and gain versus drive of 35 Boeing S-band 5525H TWTs were measured. The standard deviation in the phase about the mean phase shift measured at saturation was found to be 2.6/spl deg/, with a related standard deviation of the gain compression at saturation of 0.22 dB. These levels result in small power combining losses and small errors in phased-array fed multi-beam antennas in broadband multi-tone applications.     

Brain HMPAO-SPECT and ocular microangiopathic syndrome in HIV-1-infected patients

OBJECTIVE: The pathogenesis of neurologic and neuropsychologic dysfunction in HIV-1 infection is unclear. The purpose of the study was to determine an association between cerebral perfusion and HIV-1-related ocular microangiopathic syndrome. METHODS: We studied 28 HIV-1-infected patients, seven of whom presented with asymptomatic HIV infection, nine with lymphadenopathy syndrome or AIDS-related complex, and 12 with AIDS. Cerebral perfusion was semi-quantitatively measured by single photon emission computed tomography of the brain using technetium-99 hexamethyl-propylenamine oxime (HMPAO-SPECT). The conjunctival manifestation of HIV-1-related microangiopathic syndrome was measured by a rating scale determining blood-flow sludging and, retinal cotton-wool spots were counted. CD4 count, neopterin, beta 2-microglobulin (beta 2M), haemoglobin, and age were determined as putative confounding variables. RESULTS: Mean conjunctival sludge in patients with normal HMPAO-SPECT findings was 1.3 +/- 0.5 (mean +/- s.e.m.); no cotton-wool spots were present. In patients with slightly impaired HMPAO-SPECT, it was 2.1 +/- 0.6 and mean cotton-wool spot count was 1.1 +/- 0.4. In patients with severely impaired HMPAO-SPECT, mean conjunctival sludge was 4.5 +/- 0.3 and mean cotton-wool spot count was 4.9 +/- 1.1 HMPAO-SPECT findings were closely associated with conjunctival sludge (r = 0.72; P < 0.001) and number of cotton-wool spots (r = 0.78; P < 0.001), whereas only a slight association with staging of HIV disease was found (P = 0.052). Analysis of covariance controlling for CD4 count neopterin, beta 2M, age, and haemoglobin demonstrated a significant difference between the three HMPAO-SPECT groups for both the number of cotton-wool spots (P < 0.001) and the conjunctival sludge rating (P < 0.001). CONCLUSION: There was a close association between severity of HIV-1-related ocular microangiopathic syndrome and severity of cerebral hypoperfusion. Microvascular alterations might contribute to the pathogenesis of neurological and neuropsychological symptoms in patients with HIV-1 disease. Furthermore, the conjunctival sludge rating and the number of cotton-wool spots might be appropriate indicators for severity of microvascular changes of the central nervous system [corrected].     

SPATIAL AND VISUAL REASONING: HUMANS VERSUS LOGIC

Glasgow's revival of the "imagery debate" in computational terms provides a renewed opportunity to review the role of logical reasoning in general problem solving. Of special interest is the long-standing distinction between analogical or depictive problem representations, and the more abstract linguistic forms typified by traditional formal logic syntax.
In our brief statement, we recall that logical reasoning rests on semantics not syntax, and that the concepts of soundness, completeness, and consistency are manifest in both depictive and linguistic representations. We emerge with two conclusions: (1) enduring confusion regarding computational aspects of the "imagery debate" arise from long-standing confusion regarding key logical concepts, and related notions such as epistemological versus heuristic adequacy, logical versus probabilistic independence, and direct versus indirect representations; (2) the desire for depictive reasoning methods is ultimately motivated by human needs, not computational needs.     

Energieinformatik

Due to the increasing importance of producing and consuming energy more sustainably, Energy Informatics (EI) has evolved into a thriving research area within the CS/IS community. The article attempts to characterize this young and highly dynamic field of research by describing current EI research topics and methods and provides an outlook of how the field might evolve in the future. It is shown that two general research questions have received the most attention so far and are likely to dominate the EI research agenda in the coming years: How to leverage information and communication technology (ICT) to (1) improve energy efficiency, and (2) to integrate decentralized renewable energy sources into the power grid. Selected EI streams are reviewed, highlighting how the respective research questions are broken down into specific research projects and how EI researchers have made contributions based on their individual academic background.     

Stability under vacuum of silicon trap detectors and their use as transfer instruments in cryogenic radiometry

The stability of the responsivity of trap detectors under vacuum has been studied by means of a special chamber designed for the test of photodetectors at low pressure. The first experiments at a wavelength of 647 nm show that the responsivity variations are smaller than the uncertainties of the measurements, approximately 3 parts in 10(5), when the detector operates successively in air, under vacuum, and then again in air. Calculations based on experiments with single windowless photodiodes indicate that the change in trap responsivity that is due to vacuum effects should be smaller than 1 part in 10(5), at least in the visible part of the wavelength range. This stability makes trap detectors suitable for cryogenic radiometry when one uses transfer detectors under vacuum.     

Multilayer technology for diffractive optical elements

The proposed multilayer technology makes it possible to approximate a continuous phase distribution by discrete phase steps. Compared with binary techniques, a higher diffraction efficiency can be achieved. In most known processes a bulk substrate is used and etched directly; therefore it is difficult to control the height of the phase steps. We propose applying layers of a well-known thickness and structuring them with a selective etching process. In this new multilayer process for reflecting elements a system of metal and dielectric layers is used that can easily be produced by standard methods.     

Set-valued Lyapunov functions for difference inclusions

The paper relates set-valued Lyapunov functions to pointwise asymptotic stability in systems described by a difference inclusion. Pointwise asymptotic stability of a set is a property which requires that each point of the set be Lyapunov stable and that every solution to the inclusion, from a neighborhood of the set, be convergent and have the limit in the set. Weak set-valued Lyapunov functions are shown, via an argument resembling an invariance principle, to imply this property. Strict set-valued Lyapunov functions are shown, in the spirit of converse Lyapunov results, to always exist for closed sets that are pointwise asymptotically stable.     

Evaluation of the frequency dependence of the resistance and capacitance standards in the BIPM quadrature bridge

The Bureau International des Poids et Mesures (BIPM) has established a measurement chain allowing calibration of capacitance standards in terms of the quantized Hall resistance (QHR). An important element in the chain is a quadrature bridge linking a pair of ac resistors of values 2R/sub K/ /spl ap/ 51.6 k/spl Omega/ to a pair of capacitance standards. The quadrature bridge can be operated at five different frequencies: 513, 1027, 1541, 3082, and 6164 Hz. For such measurements, we use different ratios (1/1, 4/1 and 1/4) for the main inductive voltage divider in the quadrature bridge and three different pairs of capacitors of values 3000, 2000, and 1000 pF. A calculable coaxial resistance of 1290.6 /spl Omega/ (R/sub K//20) is used as a reference to evaluate the frequency dependence of the 51.6-k/spl Omega/ resistances. This allows the calibration of capacitance standards at the five different frequencies. The measured frequency dependences of 10 and 100 pF capacitance standards are reported.     

Analysis of quality-of-service in a wide-area interactive distance learning system

Interactive distance learning (IDL) is an evolving paradigm of instruction and learning that attempts to overcome both distance and time constraints found in traditional classroom learning. The electronic classrooms at two sites of the University of Oslo and two further sites in Norway overcome separations in space by exchanging digital audio, video, and whiteboard information via the Norwegian academic ATM-based network Supernett II. The electronic classrooms are used since 1993 for teaching graduate level courses. This paper presents measurements and analysis results of transport, application, and user level Quality-of-Service (QoS) of the electronic classrooms. We describe our general experiences with this system for synchronous IDL. The lessons learned represent the motivation for the ongoing extension to support asynchronous IDL by a multimedia database system (MMDBS) to manage all data used and generated in the electronic classrooms.