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This study introduces a new strategy that combines unsupervised learning (clustering) and transfer learning. Clustering methods are employed to generate synthetic labels for the source dataset (ICAR-2018). The generated dataset is then used for transfer learning to other histopathological datasets (KimiaPath960, CRC, Biomaging??2015, Breakhis, and Lymphoma). The comparative study based on two clustering algorithms (K-means and multi-objective clustering stream) demonstrates the efficiency of MOC-Stream. The generated synthetic histopathological dataset by this clustering algorithm outperformed the original labeled dataset and the imageNet models in transfer learning.

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