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排序方式: 共有418条查询结果,搜索用时 59 毫秒
1.
The traditional approach to severe subglottic stenosis (SGS) in the pediatric age group is laryngotracheal reconstruction (LTR). This approach may be complex and multistaged, with variable and unpredictable success rates in the individual patient. Excellent results have been reported in adults who had severe SGS and underwent partial resection of the cricoid and primary thyrotracheal anastomosis. This procedure has not been widely reported in infants and children. We report our experience with this procedure in 16 pediatric patients with grade III or IV SGS. Eleven patients had multiple previous LTR operations. The preoperative evaluation, surgical techniques, postoperative care, complications, and final results are described and discussed. Fourteen patients were decannulated after the procedure, 1 patient needed a second open procedure prior to decannulation, and 1 patient with concomitant bronchopulmonary dysplasia remains cannulated, for an overall 94% decannulation rate. Fourteen patients have no limitation of respiration, and 1 patient has moderate exercise intolerance. The results of this series suggest that partial cricotracheal resection with primary anastomosis is a relatively safe and effective procedure for pediatric patients with severe SGS. 相似文献
2.
3.
Microstructural evolution in rapidly solidified Al-Fe alloys: An alternative explanation 总被引:7,自引:0,他引:7
The solidification sequences in aluminum containing 8 and 16 wt pct iron are described in terms of the formation of metastable
and stable primary intermetallic phases. These alloys were studied in the chill-cast and splat-quenched conditions, and marked
differences in microstructure due to the different cooling rates were observed. Contrary to previous work, it is proposed
that the 50-nm intercellular particles observed in the “zone A” regions of the splat-quenched alloys are primary in nature;
this may account, in part, for their remarkable thermal stability. 相似文献
4.
Sofia Cotton Dylan Ferreira Janine Soares Andreia Peixoto Marta Relvas-Santos Rita Azevedo Paulina Piairo Lorena Diguez Carlos Palmeira Luís Lima Andr M. N. Silva Lúcio Lara Santos Jos Alexandre Ferreira 《International journal of molecular sciences》2021,22(4)
Esophageal cancer (EC) is a life-threatening disease, demanding the discovery of new biomarkers and molecular targets for precision oncology. Aberrantly glycosylated proteins hold tremendous potential towards this objective. In the current study, a series of esophageal squamous cell carcinomas (ESCC) and EC-derived circulating tumor cells (CTCs) were screened by immunoassays for the sialyl-Tn (STn) antigen, a glycan rarely expressed in healthy tissues and widely observed in aggressive gastrointestinal cancers. An ESCC cell model was glycoengineered to express STn and characterized in relation to cell proliferation and invasion in vitro. STn was found to be widely present in ESCC (70% of tumors) and in CTCs in 20% of patients, being associated with general recurrence and reduced survival. Furthermore, STn expression in ESCC cells increased invasion in vitro, while reducing cancer cells proliferation. In parallel, an ESCC mass spectrometry-based proteomics dataset, obtained from the PRIDE database, was comprehensively interrogated for abnormally glycosylated proteins. Data integration with the Target Score, an algorithm developed in-house, pinpointed the glucose transporter type 1 (GLUT1) as a biomarker of poor prognosis. GLUT1-STn glycoproteoforms were latter identified in tumor tissues in patients facing worst prognosis. Furthermore, healthy human tissues analysis suggested that STn glycosylation provided cancer specificity to GLUT1. In conclusion, STn is a biomarker of worst prognosis in EC and GLUT1-STn glycoforms may be used to increase its specificity on the stratification and targeting of aggressive ESCC forms. 相似文献
5.
Riho Kataishi Takayuki Ikeda Toshiki Sasaki Kouhei Toyotaka Daiki Nakamura Hiroyuki Miyake Yuji Iwaki Kazunori Watanabe Yuichi Yanagisawa Hisao Ikeda Harue Nakashima Nobuharu Ohsawa Shingo Eguchi Satoshi Seo Yoshiharu Hirakata Shunpei Yamazaki Daisuke Kurosaki Masakatsu Ohno Chris Bower Darryl Cotton Andrew Matthews Piers Andrew Catalin Gheorghiu Johan Bergquist 《Journal of the Society for Information Display》2014,22(8):381-392
In this study, white organic electroluminescent devices with microcavity structures were developed. A flexible high‐resolution active‐matrix organic light‐emitting diode display with low power consumption using red, green, blue, and white sub‐pixels formed by a color‐filter method was fabricated. In addition, a side‐roll touch display was developed in combination with a capacitive flexible touch screen. 相似文献
6.
Darryl P. Butt Klaus S. Lackner Christopher H. Wendt Samuel D. Conzone Harriet Kung Yung-Cheng Lu Julie K. Bremser 《Journal of the American Ceramic Society》1996,79(7):1892-1898
The kinetics of simultaneous dehydroxylation and carbonation of precipitated Mg(OH)2 were studied using isothermal and nonisothermal thermogravimetric analyses. Specimens were analyzed using X-ray diffraction, transmission electron microscopy, and through measurements of the volume of carbon dioxide evolved in a subsequent reaction with hydrochloric acid. From 275° to 475°C, the kinetics of isothermal dehydroxylation in helium were best fit to a contracting-sphere model, yielding an activation energy of 146 kJ/mol, which was greater than values reported in the literature for isothermal dehydroxylation under vacuum (53–126 kJ/mol). The carbonation kinetics were complicated by the fact that dehydroxylation occurred simultaneously. The overall kinetics also could be fit to a contracting-sphere model, yielding a net activation energy of 304 kJ/mol. The most rapid carbonation kinetics occurred near 375°C. At this temperature, Mg(OH)2 underwent rapid dehydroxylation and subsequent phase transformation, whereas thermodynamics favored the formation of carbonate. During carbonation, MgCO3 precipitated on the surface of disrupted Mg(OH)2 crystals acting as a kinetic barrier to both the outward diffusion of H2 O and the inward diffusion of CO2 . 相似文献
7.
Ryu Komatsu Ryo Nakazato Takeru Sasaki Akio Suzuki Naoyuki Senda Takuya Kawata Yasuhiro Jimbo Tomoya Aoyama Naoto Ohno Susumu Kawashima Hisao Ikeda Shingo Eguchi Yoshiharu Hirakata Shunpei Yamazaki Takashi Shiraishi Seiji Yasumoto Masataka Nakada Masataka Sato Chris Bower Darryl Cotton Andrew Matthews Piers Andrew Catalin Gheorghiu Johan Bergquist 《Journal of the Society for Information Display》2015,23(2):41-49
In this study, a 5.9‐inch foldable active‐matrix organic light emitting diode (AMOLED) display was developed. A folding test was performed repeatedly. The display survived the folding test (100,000 folds) with a curvature radius of 2 mm. To protect an organic light emitting diode (OLED) against moisture, inorganic passivation layers are provided on the upper and lower sides of the flexible display. Using our transfer technology, high density passivation layers can be obtained. The measured water vapor transmission rate of the layer is 7 × 10?6 g/m2?day or less, which improves OLED reliability. With these techniques, we have developed a book‐type display, which is repeatedly foldable like a book, and a tri‐fold display including a display area, which is foldable in three. 相似文献
8.
Jonathan Pietarila Graham Darryl D. Holm Pablo Mininni Annick Pouquet 《Journal of scientific computing》2011,49(1):21-34
The subfilter-scale (SFS) physics of regularization models are investigated to understand the regularizations’ performance
as SFS models. Suppression of spectrally local SFS interactions and conservation of small-scale circulation in the Lagrangian-averaged
Navier-Stokes α-model (LANS-α) is found to lead to the formation of rigid bodies. These contaminate the superfilter-scale energy spectrum with a scaling
that approaches k
+1 as the SFS spectra is resolved. The Clark-α and Leray-α models, truncations of LANS-α, do not conserve small-scale circulation and do not develop rigid bodies. LANS-α, however, is closest to Navier-Stokes in intermittency properties. All three models are found to be stable at high Reynolds
number. Differences between L
2 and H
1 norm models are clarified. For magnetohydrodynamics (MHD), the presence of the Lorentz force as a source (or sink) for circulation
and as a facilitator of both spectrally nonlocal large to small scale interactions as well as local SFS interactions prevents
the formation of rigid bodies in Lagrangian-averaged MHD (LAMHD-α). LAMHD-α performs well as a predictor of superfilter-scale energy spectra and of intermittent current sheets at high Reynolds numbers.
It may prove generally applicable as a MHD-LES. 相似文献
9.
We present three unsupervised artificial neural networks for the extraction of structural information from visual data. The ability of each network to represent structured knowledge in a manner easily accessible to human interpretation is illustrated using artificial visual data. These networks are used to collectively demonstrate a variety of unsupervised methods for identifying features in visual data and the structural representation of these features in terms of orientation, temporal and topographical ordering, and stereo disparity. 相似文献
10.
Brice T. Hughes Jordan M. Berg Darryl L. James Akif Ibraguimov Shaorong Liu Henryk Temkin 《Microfluidics and nanofluidics》2008,5(6):761-774
This paper presents a numerical steady-state model of ion transport in micro- and nanofluidic devices with widely varying
geometric scale, such as transitions between micro- and nanochannels. Finite element or finite volume simulation of such problems
is challenging, due to the number of elements needed to produce a satisfactory mesh. Here, only the lengthwise channel dimension
is meshed; standard analytical approximations are used to incorporate cross-channel properties. Singularly perturbed cases
are built up by continuation. The method is shown to reproduce our previously reported measurements of electric double-layer
effects on conductivity, ion concentration, and ion enhancement and depletion. Comparison with 2-D simulations reported in
the literature shows that effects on accuracy due to the 1-D approximation are small. The model incorporates analytical models
of surface charge density taken from the literature. This enables predictive simulation with reasonable accuracy using published
parameter values, or these values may be tuned based on experiment to give improved results. Use of the model for iterative
design and parameter estimation is demonstrated. 相似文献