A preliminary pharmacogenetic investigation of adverse events from topiramate in heavy drinkers.

Topiramate, an anticonvulsant medication, is an efficacious treatment for alcohol dependence. To date, little is known about genetic moderators of side effects from topiramate. The objective of this study was to examine 3 single nucleotide polymorphisms (SNPs) of the glutamate receptor GluR5 gene (GRIK1) as predictors of topiramate-induced side effects in the context of a laboratory study of topiramate. Heavy drinkers (n = 51, 19 women and 32 men), 75% of whom met criteria for an alcohol use disorder, completed a 5-week dose escalation schedule to a target dose of either 200 or 300 mg or matched placebo. The combined medication groups were compared with placebo-treated individuals for side effects at target dose. Analyses revealed that an SNP in intron 9 of the GRIK1 gene (rs2832407) was associated with the severity of topiramate-induced side effects and with serum levels of topiramate. Genes underlying glutamatergic neurotransmission, such as the GRIK1 gene, may help predict heterogeneity in topiramate-induced side effects. Future studies in larger samples are needed to more fully establish these preliminary findings. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

High-dose transdermal nicotine and naltrexone: Effects on nicotine withdrawal, urges, smoking, and effects of smoking.

Although treatment with transdermal nicotine replacement (TNR) has improved smoking abstinence rates, higher doses of TNR could improve effects on urge to smoke, nicotine withdrawal, and reinforcement from smoking, and naltrexone might further reduce reinforcement and urges. A laboratory investigation with 134 smokers using a 3 × 2 parallel-group design evaluated the effects of TNR (42-mg, 21-mg, or 0-mg patch) as crossed with a single dose of naltrexone (50 mg) versus placebo on urge to smoke, withdrawal, and responses to an opportunity to smoke (intake, subjective effects) after 10 hr of deprivation. Urge and withdrawal were assessed both prior to and after cigarette cue exposure. Only 42 mg TNR, not 21 mg, prevented urge to smoke, heart rate change, and cue-elicited increase in withdrawal. Both 21 and 42 mg TNR blocked cue-elicited drop in heart rate and arterial pressure. Naltrexone reduced cue-elicited withdrawal symptoms but not urges to smoke or deprivation-induced withdrawal prior to cue exposure. Neither medication significantly affected carbon monoxide intake or subjective effects of smoking except that 42 mg TNR resulted in lower subjective physiological activation. No interaction effects were found, and no results differed by gender. Results suggest that starting smokers with 42 mg TNR may increase comfort during initial abstinence, but limited support is seen for naltrexone during smoking abstinence. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Improving large-scale search engines with semantic annotations

Traditional search engines have become the most useful tools to search the World Wide Web. Even though they are good for certain search tasks, they may be less effective for others, such as satisfying ambiguous or synonym queries. In this paper, we propose an algorithm that, with the help of Wikipedia and collaborative semantic annotations, improves the quality of web search engines in the ranking of returned results. Our work is supported by (1) the logs generated after query searching, (2) semantic annotations of queries and (3) semantic annotations of web pages. The algorithm makes use of this information to elaborate an appropriate ranking. To validate our approach we have implemented a system that can apply the algorithm to a particular search engine. Evaluation results show that the number of relevant web resources obtained after executing a query with the algorithm is higher than the one obtained without it.     

Review of The diagnosis and treatment of alcoholism (second edition).

Reviews the book, The diagnosis and treatment of alcoholism (second edition) edited by Jack H. Mendelson and Nancy K. Mello (1985). This text is designed to be an authoritative handbook for practitioners in the field of alcohol abuse or a comprehensive textbook for graduate students. The target audience is physicians, nurses, psychologists, alcoholism counselors, social workers, and others involved in assessing and treating alcohol abuse. One way in which this text differs from many on the market is in its reliance on methodologically sound research as the basis for the recommendations and conclusions in most of the chapters, including objective discussions of controversial issues where the research data challenge commonly accepted assumptions in the alcohol field. The second edition of this volume provides valuable updating and expansion of the information presented in the widely used first edition. Overall, the second edition of this volume remains a leader in the field and will be valuable as a handbook for the clinician or textbook for the graduate seminar. The strengths of this volume are in the chapters that rely on a thorough knowledge of methodologically sound research, presented in a way that will be acceptable to clinical practitioners. Paraprofessionals may find this hard to read but advanced professionals will find the text useful. This edition remains superior to any other single resource which I can think of in the field. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Brief motivational interviewing in a hospital setting for adolescent smoking: A preliminary study.

This study tested the feasibility and efficacy of a brief smoking intervention for adolescents in a hospital seeing. Forty adolescent patients were randomized to receive either brief advice or a motivational interview, a nonconfrontational therapeutic intervention. Feasibility of brief smoking interventions with teen patients was supported by high rates of recruitment, retention, and quit attempts, and long periods of continuous abstinence. Although between-groups differences on smoking measures were not significant at 3-month follow-up, an effect size of h?=?.28 was noted. The sample showed significant decreases in smoking dependence and number of days smoked. Baseline stage of change, smoking rate, and depression were significant prospective predictors of smoking outcome. Implications for smoking intervention research with adolescents are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

The relapse situation appraisal questionnaire: Initial psychometric characteristics and validation.

Relatively few studies have examined the role of cognitive appraisal in the process of addictive relapse. This investigation was undertaken to develop a measure of primary appraisal in situations involving a high risk for cocaine relapse. The development and psychometric properties of the Relapse Situation Appraisal Questionnaire (RSAQ) are described. The RSAQ was administered to 114 adult cocaine abusers. Participants rated their appraisal of 2 hypothetical relapse risk situations. A principal-components analysis yielded a single component solution consisting of the same 26 items for the 2 situations, both involving high internal consistency. Analyses demonstrated construct, predictive, and discriminant validity. This study provides initial evidence for the psychometric validity of the RSAQ. Results support the role of primary appraisal of high-risk situations in the process of addictive relapse. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Relevance of cue reactivity to understanding alcohol and smoking relapse.

Several learning-based theories have been forwarded to account for the problem of drug relapse, including conditioned withdrawal, conditioned compensatory responding, appetitive motivational models, and social learning models. The various models are compared and evaluated against available evidence from studies with humans pertaining to alcohol and tobacco addiction. Studies that are reviewed focus primarily on the antecedents and consequences of alcohol and smoking relapse, as well as on reactions to cues that have been associated with prior drug ingestion, in an attempt to understand their motivational relevance. Problems in evaluating the various relapse models in humans are discussed. It is concluded that the appetitive model is better supported than the withdrawal model, and the compensatory model is least supported. Reactions to substance use stimuli may play an important role in alcohol and smoking relapse. Concepts drawn from the various theoretical models are linked tentatively in a schematic diagram of a hypothesized sequence of cognitive/affective, physiological, and behavioral events that lead to initial drug use after a period of abstinence (slip) and then to continued use (a relapse). The treatment implications of some of the cue reactivity models are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Brief intervention for harm reduction with alcohol-positive older adolescents in a hospital emergency department.

This study evaluated the use of a brief motivational interview (MI) to reduce alcohol-related consequences and use among adolescents treated in an emergency room (ER) following an alcohol-related event. Patients aged 18 to 19 years (N?=?94) were randomly assigned to receive either MI or standard care (SC). Assessment and intervention were conducted in the ER during or after the patient's treatment. Follow-up assessments showed that patients who received the MI had a significantly lower incidence of drinking and driving, traffic violations, alcohol-related injuries, and alcohol-related problems than patients who received SC. Both conditions showed reduced alcohol consumption. The harm-reduction focus of the MI was evident in that MI reduced negative outcomes related to drinking, beyond what was produced by the precipitating event plus SC alone. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Effect of malting regimen on diastatic power,cold and hot water extracts of malts from sorghum

In this study, sorghum grains were malted using different malting regimens and the malt qualities were analysed for cold water extract (CWE), hot water extract (HWE) and diastatic power (DP). Results showed that malting regimen produced sorghum malts with peak CWE, HWE and DP within the pre-determined limits of malting regimen. From this, predictive models of sorghum malt quality were developed and tested. Whilst steeping duration interacts significantly with the germination period to cause variations in CWE and HWE, only the germination period significantly influenced the DP of sorghum malts. However, the kilning temperature showed no significant impact on the parameters studied. Besides CWE, HWE and DP correlating positively with each other, the developed predictive models were significant (P < 0.05) and satisfy the quality of fit (R² > 0.70) of the proposed models. The result demonstrated that wort for different purposes can be obtained by varying the malting operational conditions in the predictive model, thus saving time, resources, preliminary studies and research designs. Besides the promotion of a cheaper local alternative material for industrial wort production and brewing purpose, this research provides valuable insight on the brilliant prospect of variable malting regimen in predicting and adjusting the quality characteristics of sorghum malt and wort. Future studies are required to develop models for wort produced from peak CWE, HWE and DP, for predicting wort quality characteristics.     

Knowledge management in biomedical libraries: A semantic web approach

In recent years, technological advances in high-throughput techniques and efficient data gathering methods, coupled with a world-wide effort in computational biology, have resulted in an enormous amount of life science data available in repositories devoted to biomedical literature. These repositories lack the ability to attain an effective and accurate search. Using semantic technologies as the key for interoperation enables searching and processing of biomedical literature in a more efficient way. However, emerging semantic applications take for granted specific knowledge that biomedical researchers may not have. This paper presents design principles for easy-to-use biomedical semantic applications by means of ontology-based annotations and faceted search. The proposed approach is backed with a usable prototype that shows the breakthroughs of adding these principles to a biomedical digital library where identifying and searching information are critical aspects for non-semantic Web experts.