HPLC-MS Method for Simultaneous Quantitative Determination of an Innovative Russian Gestagen and its Metabolites in Rat and Rabbit Blood Sera

Pharmaceutical Chemistry Journal - An HPLC-MS method for simultaneous quantitative determination of a novel gestagenic pharmaceutical and two of its metabolites in rat and rabbit blood sera was...     

Effect of aceclidine on scopolamine- and electroshock-induced amnesia in rats

It is found that the cholinomimetic aceclidine stimulates learning and memory processes and exerts antiamnestic effect in rats with conditioned avoidance reaction. The effect of aceclidine is not inferior to that of amiridin and surpasses that of physostigmine. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 123, No. 3, pp. 296–298, March, 1997     

Synthesis and pharmacological activity of derivatives of 3-aminomethylenindolin-2-one

Translated from Khimiko-farmatsevticheskii Zhurnal, Vol. 28, No. 4, pp. 22–26, April, 1994.     

Synthesis and pharmacological activity of derivatives of 3-aminomethylene-1-(2′,6′-dichlorophenyl)oxindole and 2-aminomethyleneindoxyl

Derivatives of 3-aminomethylene-1-(2,6-dichloro)phenyloxindole and 2-aminomethyleneindoxyl were synthesized. The¹H and¹³C NMR spectra and pharmacology of the compounds were studied.     

Remodeling of the cortical layer of the tibia after osteotomy of the femur in the same extremity

Chronobiological characteristics of temporal [correction of temper]-dimensional organization of compact bone remodelling in right tibia after the femoral diaphysis osteotomy on the same side were studied using roentgenometry and roentgenodensitometry. These characteristics were studied in experiments on 179 outbred male albino rats. Circaseptan periodicity of osseous tissue reorganization was established.     

Magnetic Ferrite Nanoparticles as a Possible Platform for Magnetic-Resonance Contrast Agents

Pharmaceutical Chemistry Journal - Ultra-small ferrite nanoparticles containing bivalent metal atoms (Fe, Mn, Mg, and Co) were synthesized as platforms for magnetic-resonance contrast agents...     

Sevoflurane and isoflurane during thoracic operations under artificial one-lung ventilation in patients at a high surgical and anesthesiological risk

The specific features of balanced anesthesia utilizing sevoflurane (versus isoflurane) during thoracic operations under artificial one-lung ventilation (AOL ) have been studied in patients at high operative and anesthetic risks. Unlike isoflurane, sevflurane fails to cause vasodilatation in both the greater and lesser circulation (including in the gas-exchange part ofpulmonary circulation). The difference of the anesthetics in their vasodilating capacity in the vessels of pulmonary and systemic circulation determines various mechanisms of pathophysiological and adaptive circulatory changes in pulmonary collapse and under AOL V Under sevoflurane anesthesia, compensatory blood flow limitation along the collaborated lung due to permanently vasohypertension in gas-exchange microcirculation is accompanied by a systemic circulatory response that is aimed at reducing right ventricular load. Termination of hypoxic pulmonary vasoconstriction in the collaborated lung occurs not early than 80-125 min of AOLV, fails to lead to recovery of impaired gas exchange due to vasohypertension and high shunt in the ventilated lung, and is attended by right ventricular overload. The latter differentiates sevoflurane anesthesia from isoflurane one wherein completion of pulmonary hypoxic vasoconstriction upon 80-125-min exposure to AOL V results in the recovery of gas exchange to the baseline levels. The pattern of reperfusion changes in ventilation emergence in the operated lung under anesthesia using both sevoflurane and isoflurane is of no significant pathological tinge and it is followed by no pulmonary and systemic metabolic disturbances. Isoflurane should be recognized to be preferable component at the stage of anesthesia maintenance in patients with cardiopulmonary diseases during thoracic operations under prolonged AOL V (more than 2 hours).     

Synthesis and pharmacological properties of 2,3,4-triaminopyridine derivatives

A series of 2-chloro-, 2-amino-, and 2-thio-substituted 6-methyl-3-nitro-4-(phenylamino)pyridines have been synthesized via the reduction of 2-amino-derivatives of 6-methyl-3-nitro-4-(phenylamino)pyridines, followed by transformation of the intermediate substituted 2,3,4-triaminopyridines into bicyclic compounds. The results of biological investigations showed that some of the synthesized compounds produce certain effects on the central nervous system of experimental animals. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 40, No. 12, pp. 8–12, December, 2006.     

Space-time organization of bone tissue remodeling in vertebral bodies after femur osteotomy

Roentgenometric and roentgenodensitometric chronobiological characteristics of space and time remodeling of the bone tissue in tail vertebra XI and XII after osteotomy of the right femur are described. Examination of 179 white non-inbred male rats revealed circadian periodicity of vertebral bone tissue remodeling. Dynamics of asymmetry of this process also has a circadian periodicity.     

Multiple organ dysfunction syndrome in newborn infants

The present paper outlines the basic idea on multiple organ dysfunctions in the newborn. The major clinical manifestations of multiple organ dysfunctions (MOD) have been studied and are described. The basic systems most susceptible to MOD are determined, and the critical stages of neonality when the development of MOD is extremely high are identified.