An Improved Method for the Synthesis of the of Indole[2,3-a]Pyrrolo[3,4-c]Carbazole-5,6-Dione N-Glycosides and their Cytotoxic Activity

Pharmaceutical Chemistry Journal - Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from...     

Magnet status attracts Russia

Follow the efforts of Moscow's Central Clinical Hospital as it prepares a project demonstration for the Magnet Nursing Services Recognition Program of the American Nurses Credentialing Center.     

Autoantibodies to Nerve Growth Factor in Disorders of Mental Development in Infants

Studies were performed using 80 children aged 1–3 years with lesions to mental development. Patients were divided into three groups according to the severity and structure of lesions of mental development: those most strongly characterized by delayed speech development (group 1), those with delayed mental development due to organic CNS lesions (group 2), and those with abnormal mental development and high levels of psychopathological symptoms (group 3). There were significant increases (p < 0.001) in blood levels of autoantibodies to nerve growth factor (NGF) in children in each of these groups as compared with a control group (0.75 ± 0.24 OD units). The levels of anti-NGF autoantibodies increased from group 1 to group 3 (0.95 ± 0.24 OD units in group 1, 1.13 ± 0.27 OD units in group 2, and 1.24 ± 0.4 OD units in group 3). These correlations suggest that the level of anti-NGF autoantibodies can, taken in conjunction with a number of other parameters, be regarded as a potential molecular marker demonstrating abnormal development of the nervous system.     

On non-uniform changes in the electrical activity of the respiratory muscles associated with experimental injury of the peritoneum

Summary Changes of the electric activity were studied prior to and after the peritoneal injury (causing contracture of the abdominal wall) in the diaphragm, intercostal muscles (intracartilagenous portion of the 4th–5th intercostal space), and m. obliquus abdominis and rectus abdominis. This was done on dogs and rabbits with the aid of implanted electrodes.As shown experimentally, the respiratory rhythm was retained completely both in the diaphragm and the interostal muscles during the whole observation period. The activity of the abdominal muscles changes, depending on the stage of the pathological process, but the respiratory rhythm therein may be absent for a scope of minutes in the m. obliquus abdominis and up to 1–2 days in the rectus abdominis. These experiments confirm the possibility of segmentary disturbances of the respiratory muscles' function in the presence of a pathological focus at the periphery.(Presented by Active Member of the Akad. Med. Nauk SSSR V. V. Parin) Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 52, No. 11, pp. 30–35, November, 1961     

Afferent impulses in single vagal fibers in pulmonary damage (the nature of pathological impulses)

Summary Recordings from single afferent vagal fibers were made after focal injury to the lungs and revealed the following alterations in pulmonary receptor activity: 1) temporary disappearance of stretch-receptor activity, evidently due to the transient collapse of the pulmonary area containing the receptor; 2) continuation of stretch receptor activity during expiration, evidently due to the development of focal emphysema in the receptor area; 3) the development of low amplitude activity during expiration, which was not recorded during expiration of the same volume prior to injury. The effect may very likely be explained by receptor sensitization caused by the injury. It is suggested that in addition to impulses from the pulmonary focus itself, the pathological impulses may originate from receptors beyond the focus, the effect being todisorganize rather than to intensify the discharge.(Presented by Active Member AMN SSSR V. V. Parin) Translated from Byulleten'Éksperimental'noi Biologii i Meditsiny, Vol. 51, No. 6, pp. 29–32, June, 1961