The framing of relative performance feedback: Seeing the glass as half empty or half full.

It was proposed that individuals' responses to information regarding their relative position in a performance distribution would depend on how they frame the information. To the degree that they focus selectively on the positive features of the feedback (i.e., the number of others who performed worse than them) rather than the negative features (i.e., the number of others who performed better than them) they should report higher ability levels and more positive affective reactions. In Study I, Ss received feedback indicating that they occupied a particular percentile standing in either a large or small distribution. Individuals with negative orientations (depressives and pessimists) reported lower ability levels as a function of increases in comparison group size, whereas individuals with positive orientations (nondepressives and optimists) reported higher ability levels. Presumably, these effects occurred because negatively oriented persons focused on the negative features of the feedback and positively oriented persons focused on the positive features of the feedback. The results of Study 2 support this explanation. Implications for the social comparison literature are discussed. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

T cell response to two immunodominant proteolipid protein (PLP) peptides in multiple sclerosis patients and healthy controls

Despite the fact that the neuroleptic drugs have been widely used for more than 40 years, one of their most common side-effects, akathisia, has been relatively neglected. There are still no universally agreed diagnostic criteria for akathisia, particularly chronic akathisia, and in this review article, we discuss the controversies surrounding the voluntary nature of its motor features and the importance of the dysphoric component. We also review the published epidemiological studies to show the great variation in frequency of occurrence. Finally, we discuss the possible neurotransmitters involved in the pathophysiology and treatment of this condition.     

Comparison of Particle Number Counts Measured with an Ink Jet Aerosol Generator and an Aerodynamic Particle Sizer

Aerodynamic particle sizer (APS) users typically calibrate the particle sizing capabilities, but not the counting efficiency upon which aerosol concentration results are based. Herein, comparisons were made between the counts provided by an ink jet aerosol generator (IJAG) with those measured by an APS. Near-monodisperse (geometric standard deviation of about 1.06) liquid or solid aerosols in the size range of 0.95 to 13.3 μm aerodynamic diameter (AD) generated with an IJAG were released into the inner inlet-tube of the APS in a manner that rendered APS wall and aspiration losses negligible. For most experiments, the IJAG generated 75 particles/s, which rate was maintained by the IJAG system through control of electrical pulses applied to its ink jet cartridge. For particles in the size range of 2–13.3 μm AD, the ratio of relative detection efficiency (ratio of the number of particles counted by the APS to the number reported as generated by the IJAG) was 99.3 ± 1.4%; however, for test particles between 0.95 and 2 μm AD, the relative detection efficiency was somewhat lower, but the drop off was less than about 2%. This slight drop off is likely associated with the light scattering detection approach and corresponding counting algorithm of the APS. Tests were conducted where the IJAG produced 7.0 μm AD particles at rates of 1 to 500 s^-1 and the results showed essentially a 1:1 correspondence between IJAG and APS counts. The presence of smaller-sized background particles did not affect the measured APS counts of larger-sized challenge particles.

Copyright 2014 American Association for Aerosol Research     

Determinant spreading associated with demyelination in a nonhuman primate model of multiple sclerosis

Definition of the immune process that causes demyelination in multiple sclerosis is essential to determine the feasibility of Ag-directed immunotherapy. Using the nonhuman primate, Callithrix jacchus jacchus (common marmoset), we show that immunization with myelin basic protein and proteolipid protein determinants results in clinical disease with significant demyelination. Demyelination was associated with spreading to myelin oligodendrocyte glycoprotein (MOG) determinants that generated anti-MOG serum Abs and Ig deposition in central nervous system white matter lesions. These data associate intermolecular "determinant spreading" with clinical autoimmune disease in primates and raise important issues for the pathogenesis and treatment of multiple sclerosis.     

Biased recollections in older adults: The role of implicit theories of aging.

Explored how older adults recall the traits they possessed at an earlier age. It was hypothesized that older adults' recollections would be related to their theories about aging. In Study 1, a group of older Ss provided their theories concerning how various traits change with age. Another group of older Ss rated their current status on these traits and recalled the status they possessed at a younger age. In addition, a group of younger adults rated their current status on the same traits. On traits theorized to increase with age, older Ss recalled themselves as possessing lower levels at an earlier age than the younger group reported possessing. On traits theorized to decrease with age, older Ss recalled themselves as possessing higher levels at an earlier age than the younger group reported possessing. Study 2 indicated that this effect is obtained regardless of trait positivity. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Association between human immunodeficiency virus and herpes simplex virus type 2 seropositivity among male factory workers in Zimbabwe

To determine the seroprevalence of herpes simplex virus type 2 (HSV-2), to identify correlates of infection, and to describe the correlation with human immunodeficiency virus (HIV) seropositivity, 224 HIV-negative and 191 HIV-positive male factory workers in Zimbabwe were screened for HSV-2-specific antibodies. HSV-2 seroprevalence was 35.7% among HIV-negative subjects and 82.7% among HIV-positive subjects. The weighted estimate of HSV-2 seroprevalence in this population is 44.6%. The correlation between HIV and HSV-2 remained significant after controlling for multiple sex partners, paying for sex, and history of sexually transmitted disease (adjusted odds ratio, 8.0; 95% confidence interval, 4.8-13.1). If the association between HSV-2 and HIV is causal, then the high seroprevalence of HIV and HSV-2 suggests that suppressive HSV-2 treatment should be considered as a strategy to reduce HIV transmission in this population. HSV-2 seroconversion may be a suitable surrogate end point to evaluate HIV prevention interventions.     

Haloperidol does not affect motivational processes in an operant runway model of food-seeking behavior.

The present experiment examined the effects of dopamine receptor antagonism on subjects' motivation to seek food. Rats were trained to discriminate between 2 olfactory cues predicting either the presence (S+) or absence (S–) of food reinforcement in the goal box of a straight-arm runway. Rats learned to traverse the alley quickly when presented with the S+ and much more slowly when presented with the S–. Haloperidol pretreatment was unable to alter this pattern of behavior (i.e., rats still ran quickly when presented with the scent that predicted food availability). Thus, it seems that the same dopamine antagonist treatments that have been shown to disrupt food reinforcement do not prevent the food-seeking behavior produced by presentation of food-predictive cues. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Aerosol Deposition in Sampling Probes

Deposition of aerosol particles on the inner walls of sampling probes is of concern in many aerosol sampling applications. Only inertial and gravitational effects have been considered in previous studies of the aerosol deposition; however, the lift force on particles is also of significance. In this investigation, experiments have been conducted to construct a database for aerosol deposition in Willeke-type sampling probes. An empirical correlation has been made between wall losses and the depositional forces of drag, gravity, inertia, and particle lift through the use of dimensionless parameters. Inclusion of the lift effect in this correlation not only helps to better predict particle behavior in the sampling inlet, but it also provides a basis for understanding of the intrinsic deposition phenomenon. The correlation has a geometric standard deviation of 1.13 and a 0.93 correlation coefficient relative to the experimental data.