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Leisha Diane Nolen Lynda Osadebe Jacques Katomba Jacques Likofata Daniel Mukadi Benjamin Monroe Jeffrey Doty Lem's Kalemba Jean Malekani Joelle Kabamba Pierre Lokwa Bomponda Jules Inonga Lokota Marcel Pie Balilo Toutou Likafi Robert Shongo Lushima Jean-Jacques Muyembe Tamfum Emile Wemakoy Okitolonda Andrea M. McCollum Mary G. Reynolds 《The American journal of tropical medicine and hygiene》2015,93(2):410-415
An increased incidence of monkeypox (MPX) infections in the Democratic Republic of the Congo was noted by the regional surveillance system in October 2013. Little information exists regarding how MPX is introduced into the community and the factors associated with transmission within the household. Sixty-eight wild animals were collected and tested for Orthopoxvirus. Two of three rope squirrels (Funisciurus sp.) were positive for antibodies to Orthopoxviruses; however, no increased risk was associated with the consumption or preparation of rope squirrels. A retrospective cohort investigation and a case–control investigation were performed to identify risk factors affecting the introduction of monkeypox virus (MPXV) into the community and transmission within the home. School-age males were the individuals most frequently identified as the first person infected in the household and were the group most frequently affected overall. Risk factors of acquiring MPXV in a household included sleeping in the same room or bed, or using the same plate or cup as the primary case. There was no significant risk associated with eating or processing of wild animals. Activities associated with an increased risk of MPXV transmission all have potential for virus exposure to the mucosa. 相似文献
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Leisha Diane Nolen Lynda Osadebe Jacques Katomba Jacques Likofata Daniel Mukadi Benjamin Monroe Jeffrey Doty Christine Marie Hughes Joelle Kabamba Jean Malekani Pierre Lokwa Bomponda Jules Inonga Lokota Marcel Pie Balilo Toutou Likafi Robert Shongo Lushima Benoit Kebela Ilunga Frida Nkawa Elisabeth Pukuta Stomy Karhemere Jean-Jacques Muyembe Tamfum Beatrice Nguete Emile Okitolonda Wemakoy Andrea M. McCollum Mary G. Reynolds 《Emerging infectious diseases》2016,22(6):1014-1021
A 600-fold increase in monkeypox cases occurred in the Bokungu Health Zone of the Democratic Republic of the Congo during the second half of 2013; this increase prompted an outbreak investigation. A total of 104 possible cases were reported from this health zone; among 60 suspected cases that were tested, 50 (48.1%) cases were confirmed by laboratory testing, and 10 (9.6%) tested negative for monkeypox virus (MPXV) infection. The household attack rate (i.e., rate of persons living with an infected person that develop symptoms of MPXV infection) was 50%. Nine families showed >1 transmission event, and >6 transmission events occurred within this health zone. Mean incubation period was 8 days (range 4–14 days). The high attack rate and transmission observed in this study reinforce the importance of surveillance and rapid identification of monkeypox cases. Community education and training are needed to prevent transmission of MPXV infection during outbreaks. 相似文献
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Jessica Leung Andrea M. McCollum Kay Radford Christine Hughes Adriana S. Lopez Sarah Anne J. Guagliardo Beatrice Nguete Toutou Likafi Joelle Kabamba Jean Malekani Robert Shongo Lushima Elisabeth Pukuta Stomy Karhemere Jean Jacques Muyembe Tamfum Mary G. Reynolds Emile Wemakoy Okitolonda D. Scott Schmid Mona Marin 《Tropical medicine & international health : TM & IH》2019,24(7):839-848
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