全文获取类型
收费全文 | 4178篇 |
免费 | 546篇 |
国内免费 | 169篇 |
学科分类
工业技术 | 4893篇 |
出版年
2024年 | 20篇 |
2023年 | 96篇 |
2022年 | 145篇 |
2021年 | 206篇 |
2020年 | 165篇 |
2019年 | 122篇 |
2018年 | 141篇 |
2017年 | 180篇 |
2016年 | 153篇 |
2015年 | 217篇 |
2014年 | 228篇 |
2013年 | 208篇 |
2012年 | 238篇 |
2011年 | 270篇 |
2010年 | 249篇 |
2009年 | 250篇 |
2008年 | 220篇 |
2007年 | 187篇 |
2006年 | 254篇 |
2005年 | 179篇 |
2004年 | 122篇 |
2003年 | 122篇 |
2002年 | 95篇 |
2001年 | 79篇 |
2000年 | 120篇 |
1999年 | 101篇 |
1998年 | 74篇 |
1997年 | 97篇 |
1996年 | 77篇 |
1995年 | 51篇 |
1994年 | 46篇 |
1993年 | 42篇 |
1992年 | 30篇 |
1991年 | 23篇 |
1990年 | 25篇 |
1989年 | 19篇 |
1988年 | 13篇 |
1987年 | 3篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1980年 | 1篇 |
1968年 | 1篇 |
1965年 | 1篇 |
1956年 | 1篇 |
1951年 | 3篇 |
排序方式: 共有4893条查询结果,搜索用时 31 毫秒
1.
Ping Xiao Jue Wang Lei Fang Zitong Zhao Xiangshi Sun Xiaochen Liu Haiqiang Cao Pengcheng Zhang Dangge Wang Yaping Li 《Advanced functional materials》2021,31(36):2104068
Neoantigen vaccines and adoptive dendritic cell (DC) transfer are major clinical approaches to initiate personalized immunity in cancer patients. However, the immunization efficacy is largely limited by the in vivo trajectory including neoantigens’ access to resident DCs and DCs’ access to lymph nodes (LNs). Herein, an innovative strategy is proposed to improve personalized immunization through neoantigen-loaded nanovaccines synergized with adoptive DC transfer. It is found that it enables selective delivery of neoantigens to resident DCs and macrophages by coating cancer cell membranes onto neoantigen-loaded nanoparticles. In addition, the nanovaccines promote the secretion of chemokine C-C motif ligand 2 (CCL2), CCL3, and C-X-C motif ligand 10 from macrophages, thus potentiating the access of transferred DCs to LNs. This immunization strategy enables coordinated delivery of identified neoantigens and autologous tumor lysate-derived undefined antigens, leading to initiation of antitumor T cell immunity in a personalized manner. It significantly inhibits tumor growth in prophylactic and established mouse tumor models. The findings provide a new vision for potentiating adoptive cell transfer by nanovaccines, which may open the door to a transformative possibility for improving personalized immunization. 相似文献
2.
AbstractDifferent drying methods (spray drying (SD), vacuum drying (VD), microwave vacuum drying (MVD), and infrared vacuum drying (IFVD)) were applied in order to compare the hygroscopicity behavior of chicken powders. The hygroscopicity curves and glass transition temperature were used to evaluate the influence of ambient humidity and temperature on moisture absorption of powders. The results showed that the chicken powder dried by MVD had the lowest moisture absorption, followed by IFVD, VD, and SD. The hygroscopicity of SD chicken powders was different from other three kinds of chicken powders due to the physical properties of particles and the changes of protein secondary structure as detected by the Fourier transform-infrared spectrometer. For the three vacuum drying methods, the difference of protein secondary structure was the main reason of differences in hygroscopicity. Although MVD chicken powders were slightly inferior to SD chicken powders in taste, MVD chicken powders were the best in terms of smell and color as suggested by instrumental sensory parameter evaluations. It was found that MVD had a positive effect on reducing moisture absorption and maintaining sensory quality of chicken powders. 相似文献
3.
不同折流板结构螺旋折流板换热器传热性能的比较(英文) 总被引:1,自引:0,他引:1
Numerical simulations were performed on flow and heat transfer performances of heat exchangers having six helical baffles of different baffle shapes and assembly configurations, i.e., two trisection baffle schemes, two quadrant baffle schemes, and two continuous helical baffle schemes. The temperature contour or the pressure contour and velocity contour plots with superimposed velocity vectors on meridian, transverse and unfolded concentric hexagonal slices are presented to obtain a full angular view. For the six helix baffled heat exchangers, the different patterns of the single vortex secondary flow and the shortcut leakage flow were depicted as wel as the heat transfer properties were compared. The results show that the optimum scheme among the six configurations is a circumferential overlap trisection helix baffled heat exchanger with a baffle incline angle of 20° (20°TCO) scheme with an anti-shortcut baffle structure, which exhibits the second highest pressure dropΔpo, the highest overal heat transfer coefficient K, shel-side heat transfer coefficient ho and shel-side average comprehensive index ho/Δpo. 相似文献
4.
5.
6.
7.
该文分析了弹道靶道测量中的精度问题及通常使用的静态检测方法,并针对静态检测与靶道实测相差甚远的问题,提出了一种动态检测方法.该方法充分考虑到弹道靶道的测量对象是高速飞行体以及照片质量、气流附面层、发射时的恶劣环境和振动等因素对测量精度的影响,结合误差理论,给出了动态精度的计算公式,在已建成的IB-12中间弹道靶道中应用,效果良好. 相似文献
8.
Erv J. Kuhlmann Dick Y. Jung Richard P. Guptill Charles A. Dyke Hyung K. Zang 《Fuel》1985,64(11):1552-1557
The presence of hydroaromatic, hydrogen donor components in a coal-derived solvent is one of the more important factors in the successful operation of a non-catalytic coal liquefaction process. Various hydrogen donor species present in a hydrogenated creosote oil have been identified. Their rate of disappearance under conditions that are consistent with a short residence time coal liquefaction process has been used to rank the reactivities of the various hydrogen donors. 1,2,3,10b-Tetrahydrofluoranthene was found to be an exceptional donor while 4,5-dihydropyrene, the hexahydropyrenes and 9,10-dihydrophenanthrene were found to be quite active. Sym.-octahydrophenanthrene and 2a,3,4,5-tetrahydroacenaphthene exhibited moderate activity. Tetralin and the four methyltetralin isomers were found to be unreactive under the coal liquefaction conditions employed. 相似文献
9.
水电站辅助设备的运行直接影响水电站运行的安全性和可靠性。二滩水电站投运初期,油、水、风系统先后出现了许多问题,通过应用新产品和新技术对其进行了改造。为水电厂辅助设备的设计、选型、安装提供了宝贵的经验,并对水电厂辅助设备的检修、调试和运行维护有一定的指导作用。 相似文献
10.
从分析石油焦原料着手,考察了其热解特性、孔隙率和石墨化程度。由于石油焦结构致密,属易石墨化碳,因此用水蒸气法直接活化得到的炭质材料吸附性能差,其碘吸附值小于350mg/g。不同来源的石油焦由于组成不同,其活化性能也有差异。通过成型法,以金山石油焦为原料轻预炭化、预氧化和炭化,得到炭化料,再用水蒸气活化得到的活性炭的碘吸附值达800.40mg/g、亚甲蓝值达120.40mg/g。以独山子石油焦为主要原料制得的活性炭的碘吸附值与亚甲蓝值分别达871.58mg/g、100..67mg/g。 相似文献