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Yegireddy Muralidhar Mekapogu Alpha Raj Tollamadugu NagaVenkata KrishanVara Prasad Thota Venkata Chaitanya Kumar Kaliki Adilaxmamma Chinthamaneni Srilatha G. Sreeenivasa Rao Pothireddy Sreevani Nagireddy Aparna 《IET nanobiotechnology / IET》2017,11(6):682
Mastitis is an important economic disease causing production losses in dairy industry. Antibiotics are becoming ineffective in controlling mastitis due to the emergence of resistant strains requiring the development of novel therapeutic agents. In this study, the authors present the phytochemical synthesis of silver nanoparticles (AgNPs) with acetyl‐11‐α‐keto‐β‐boswellic acid and evaluation of their activity in Staphylococcus aureus induced murine mastitis. Boswellic acid mediated AgNP (BANS) were oval, polydispersed (99.8 nm) with an minimum inhibitory concentration of 0.033 µg ml−1 against S. aureus, inhibitory concentration (IC50) of 30.04 µg ml−1 on mouse splenocytes and safe at an in vivo acute oral dose of 3.5 mg kg−1 in mice. Mastitis was induced in lactating mice by inoculating S. aureus (log10 5.60 cfu) and treated 6 h post‐inoculation with BANS (0.12 mg kg−1, intramammary and intraperitoneal), and cefepime (1 mg kg−1, intraperitoneal). S. aureus inoculated mice showed increased bacterial load, neutrophil infiltration in mammary glands and elevated C‐reactive protein (CRP) in serum. Oxidative stress was also observed with elevated malondialdehyde level, superoxide dismutase (SOD) and catalase (CAT) activities. BANS treatment significantly (P < 0.05) reduced bacterial load, CRP, SOD, CAT activities and neutrophil infiltration in affected mammary glands. BANS could be a potential therapeutic agent for managing bovine mastitis.Inspec keywords: nanomedicine, nanoparticles, silver, antibacterial activity, drugs, diseases, enzymesOther keywords: antibacterial effects, antiinflammatory effects, antioxidant effects, acetyl‐11‐α‐keto‐β‐boswellic acid, mediated silver nanoparticles, experimental murine mastitis, economic disease, dairy industry, resistant strains, phytochemical synthesis, Staphylococcus aureus, minimum inhibitory concentration, inoculating S. aureus, neutrophil infiltration, mammary glands, elevated C‐reactive protein, superoxide dismutase, catalase, bovine mastitis, Ag 相似文献
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Sreevani Pothireddy Adilaxmamma Kaliki Alpha Raj Mekapogu Muralidhar Yegireddy Eswara Prasad Pagadala Tollamadugu Naga Venkata Krishna Vara Prasad 《IET nanobiotechnology / IET》2016,10(5):340
Wound healing requires a series of cellular events and a cascade of co‐ordinated and systemic biochemical events. Silver nanoparticles possess many beneficial properties for wound management including antibacterial, anti‐inflammatory and pro‐healing properties. In this study, the authors investigated the wound healing properties of Cinnamomum verum extract mediated nanosilver (CENS) particles in comparison with 1% povidone iodine, citrate mediate NS and CE treatments. The topical application of CENS showed good antibacterial activity and accelerated wound healing with complete epithelialisation and normal re‐growth of hair in all three models of study: namely, excision, incision and dead space models in rats compared with all other treatments. CENS was also found to promote collagen synthesis, stabilise wound besides countering oxidative stress and stimulating cellular proliferation CENS could be a novel therapeutic agent for wound management.Inspec keywords: silver, nanoparticles, nanomedicine, wounds, antibacterial activity, biomedical materials, biochemistry, cellular biophysics, proteinsOther keywords: wound healing efficacy, chemical nanoparticles, phytogenic silver nanoparticles, cellular events, systemic biochemical events, wound management, antibacterial properties, anti‐inflammatory properties, pro‐healing properties, Cinnamomum verum extract mediated nanosilver particles, CENS, complete epithelialisation, normal hair regrowth, excision model, incision model, dead space model, rats, collagen synthesis, oxidative stress, cellular proliferation, therapeutic agent, Ag 相似文献
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Silicon - In this ultramodern scenario, low power, less cost and reduced storage devices are in great demand. Because the majority devices operate on a remote power supply, low-power memories are... 相似文献
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