全断面富水砂层浅埋暗挖隧道施工技术

针对广州市轨道交通三号线永泰站过街商业暗挖隧通道所处全断面富水砂层复杂地质条件,采用了超前分段后退式双液注浆、围壁注浆、扩散注浆、下导洞引水、上导洞留核心土等施工技术,解决了暗挖通道埋藏浅、地下水丰富、全断面砂层、流水流砂、冲积-洪积粉细砂层遇水软化等难题,取得了成功。     

复杂地质条件下地铁深基坑优化设计与施工技术

针对珠江三角洲城际快速轨道交通广州至佛山段项目5标段[雷岗站]地质条件非常复杂,局部位置存在破碎带、溶洞以及岩面浅,连续墙入岩深度大等情况,通过支护体系的优化和溶洞、破碎带的针对性技术措施的实施,解决了工期紧及岩溶地层深基坑施工的难题,取得成功。     

Energy-saving estimation model for hypermarket HVAC systems applications

Energy saving estimation model (ESEM) use normal distribution (Gaussian) probability theory to predict potential savings for previously determined system improvements. Those improvements are low/high cost investments based on data gathered during one year monitoring of typical hypermarket facility HVAC system. The consumption of electrical energy and natural gas has been monitored and system segments with largest amount of energy consumption have been marked. Gathered data pointed out to fan units as the biggest energy consumers and suggested that system energy-saving improvement must be focused on fans energy consumption control. This paper deals with ESEM inputs and outputs in order to provide correct financial estimation of specific investment.     

现代建筑的新型楼盖结构体系

总结了现代建筑的多种钢筋混凝土和预应力混凝土结构楼盖体系的技术性能、施工特点、设计计算方法的要点。重点介绍了在跨度(或柱网)为6～12m的多层与高层建筑中应用的三种新型的预应力混凝土楼盖结构体系:密肋板、空心板和夹层板,及如何合理地选择这些楼盖体系。对8.4m×8.4m柱网的多种轻型楼板组成的楼盖结构体系与常规的梁板和实心板进行了技术经济比较,提出了控制结构层高度、结构层折算厚度和结构自重的建议。     

地下连续墙双止水钢板接头施工技术研究

以广州地铁雷岗公园站围护结构地下连续墙为载体,对地下连续墙双止水钢板接头方式进行研究与实践,取得了一定的成果。该技术的止水效果良好,并且经济、环保、施工速度快,得到了各方的肯定。     

曲线盾构隧道内大直径内衬钢管的安装及外包混凝土施工技术

广州市西江引水输水管线小塘立交段工程,采用在外径6.0 m、内径5.4 m的曲线盾构隧道内安装DN 4 800 mm内衬钢管。由于隧道内安装内衬钢管后,隧道壁与内衬钢管间隙仅为280mm,需浇筑内衬钢管外包混凝土。为此,专门制定了相对应的施工技术,确保了隧道施工顺利完成。     

Effects of Haloperidol,Risperidone, and Aripiprazole on the Immunometabolic Properties of BV-2 Microglial Cells

Microglial cells are resident macrophages in the brain that have been implicated in the pathophysiology of schizophrenia. There is a lack of studies covering the effects of antipsychotics on microglial cells. The current literature points to a possible anti-inflammatory action without clear mechanisms of action. The aim of this study is to characterize the effects of haloperidol, risperidone and aripiprazole on BV-2 microglial cells in in vitro conditions. We have used immunofluorescence and flow cytometry to analyze the classical pro and anti-inflammatory markers, while a real-time metabolic assay (Seahorse) was used to assess metabolic function. We analyzed the expression of p70S6K to evaluate the mTOR pathway activity with Western blot. In this study, we demonstrate the varying effects of haloperidol, risperidone and aripiprazole administration in BV-2 microglial cells. All three tested antipsychotics were successful in reducing the pro-inflammatory action of microglial cells, although only aripiprazole increased the expression of anti-inflammatory markers. Most significant differences in the possible mechanisms of action were seen in the real-time metabolic assays and in the mTORC1 signaling pathway activity, with aripiprazole being the only antipsychotic to reduce the mTORC1 activity. Our results shed some new light on the effects of haloperidol, risperidone and aripiprazole action in microglial cells, and reveal a novel possible mechanism of action for aripiprazole.     

A novel integrated large-scale group MCDM model under fuzzy environment for selection of reach stacker in a container terminal

Applied Intelligence - The selection of transshipment and handling machinery in container terminals is a complex and responsible task due to a number of daily operations required. Accordingly,...     

Relationship between non‐alcoholic fatty liver disease and MIA syndrome

Non‐alcoholic fatty liver disease (NAFLD) is an important factor in the pathogenesis of cardiovascular diseases in the general population. Recently, it has been shown that NAFLD is highly prevalent in chronic kidney disease (CKD) patients. Ninety‐four hemodialysis (HD) patients were followed for a time period of 18 months or until death. Patient's survival rate was determined in relation to their nutritional and inflammatory state, and the presence of NAFLD. We also investigated the association between the presence of NAFLD and the patients' nutritional and inflammatory state. We did not find any significant association between the clinical parameters of nutritional status and the mortality rate. However, the mortality rate was statistically significantly higher in patients with low serum albumin and high high‐sensitive C‐reactive protein (hs‐CRP) levels and in those who had NAFLD. Surprisingly, patients who had received enteral nutrition did not have a better survival rate. The severity of liver steatosis was negatively correlated with the serum albumin levels, while it was positively correlated with hs‐CRP values. Furthermore, serum albumin levels showed a negative correlation with hs‐CRP levels. We did not find any significant association between the presence of NAFLD and clinical parameters of nutrition. We have shown that NAFLD could be one more possible example of reverse epidemiology in patients undergoing HD. NAFLD may be the missing link that causally ties malnutrition, inflammation, and atherosclerosis syndrome to the morbidity and mortality in patients undergoing HD.