Characterization,in vitro bioactivity and biological studies of sol-gel-derived TiO2 substituted 58S bioactive glass

Bioactive glasses (BGs) have been used for bone formation and bone repair processes in recent years. This study investigated the titanium substitution effect on 58S BGs (Ti-BGs) 60SiO₂-(36 − X)CaO-4P₂O₅-XTiO₂ (X = 0, 3, and 5 mol.%) prepared by the sol-gel technique, and the main goal was to find the optimum amount of titanium in Ti-BGs. Synthesized BGs, which were investigated after immersion in simulated body fluid (SBF), were tested by X-ray diffraction (XRD) analysis, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy. Moreover alkaline phosphate (ALP) activity, 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and antibacterial studies were employed to investigate the biological properties of Ti-BGs. According to the FTIR and XRD test results, hydroxyapatite (HA) formation on Ti-BGs surfaces was confirmed. Meanwhile, the presence of 5 mol.% compared to 3 mol.% increased the HA grain distribution and their size on the Ti-BGs surface. Additionally, MTT and ALP results confirmed that the optimal amount of titanium substitution in BG was 5 mol.%. Since 5 mol.% Ti incorporated BG (BG-5) had the highest biocompatibility level, antibacterial properties, maximum cell proliferation, and ALP activity among the synthesized Ti-BGs, it is presented as the best candidate for further in vivo investigations.     

Synthesis of nanoporous Baghdadite by a modified sol-gel method and its structural and controlled release properties

In this research, a bimodal nanoporous Baghdadite (NB) (Ca3ZrSi2O9) was prepared by a modified sol-gel method using P123 as a surfactant. The effects of P123's contents on the structural and textural properties as well as the drug delivery behavior of NB were assessed in vitro. The usage of P123 offered a new route for the synthesis of NB. The synthesized NB samples with different amounts of P123 were studied through X-ray diffraction (XRD), Fourier transform infrared spectra (FTIR), N2 adsorption-desorption, field emission scanning electron microscopy (FESEM) equipped with energy-dispersive X-ray analysis spectroscopy (EDAX) and transmission electron microscopy (TEM). The results showed that a single-phase Baghdadite was obtained by this new method at the calcination temperature of 800?°C. It was found that an increase in P123's content up to 0.025?mol changed the morphology of NB samples from mountain-like to needle-like. The potential application of NB samples as drug delivery agents was assessed by estimating their release properties up to 240?h. This research revealed that the synthesized Baghdadite could be used as a potential nanoporous carrier with controlled release capability in bone tissue regeneration.     

Anti-D in a D-positive renal transplant patient

PURPOSE: We report a case of postoperative reparalysis in the recovery room, following nebulized epinephrine. The patient was pharmacologically reversed with edrophonium after paralysis with rocuronium. CLINICAL FINDINGS: A 12-yr-old girl developed postoperative reparalysis following the intraoperative administration of rocuronium. A total of 0.92 mg.kg-1 rocuronium was administered. After surgery, pharmacological reversal was achieved with 20 mg edrophonium with 0.15 mg atropine sulfate iv 35 min after the last administration of rocuronium. Muscular relaxation was monitored using an ulnar peripheral nerve stimulator (PNS). After reversal, a full train-of-four and sustained tetanus at 50 Hz were present. In the recovery room, following nebulized epinephrine, the patient became apneic. The patient was paralyzed and an ulnar PNS demonstrated only one faint twitch. The paralysis was reversed with 1.5 mg neostigmine with 0.3 mg glycopyrrolate. CONCLUSION: Postoperative reparalysis following rocuronium may be a cause of postoperative respiratory distress. The definitive diagnosis is made using PNS and observing the response to pharmacological reversal. Nebulized epinephrine may have a previously undescribed role in the development of postoperative reparalysis.     

Dynamic Analysis of Truss‐Beam System

As the manned exploration of space continues, many complex structural components are being developed to construct the orbital platforms that will be used to house communication hardware, personnel, and manufacturing complexes. These components are extremely flexible and complex in their behavior. There is a need for a simple method for determining the dynamic characteristics of these space structures with a minimum of effort. A mathematical model of one of these structural elements, an articulating truss beam, has been developed to predict its dynamic response. Assumptions of the force interaction between the beam elements and the joints have been made for using this model. Algorithms are provided to determine the flexibility matrix of the truss beam for use in the equation of motion. The natural frequencies obtained from using this method are compared with those obtained by the finite element method. An experimental procedure is planned to validate the results from the theoretical method.     

Estimates of intakes: methodology and results of some studies carried out in Italy.

The methods which may be applied to estimating population intakes of food additives are outlined. The applications in studies of the intakes of some preservatives and food colours in Italy are reported. It was concluded that there is a need to investigate comparability between the various methods used. The surveys carried out indicated that, in general, the levels of consumption of the additives studied did not present a health risk.     

A new framework for sign language alphabet hand posture recognition using geometrical features through artificial neural network (part 1)

Neural Computing and Applications - Hand pose tracking is essential in sign languages. An automatic recognition of performed hand signs facilitates a number of applications, especially for people...     

Performance analysis of multimedia based web traffic with QoS constraints

During the recent years, there has been a tremendous growth in the development and deployment of multimedia based networked applications such as video streaming, IP telephony, interactive games, among others. These applications, in contrast to elastic applications such as email and data sharing, are delay and delay jitter sensitive but can tolerate certain level of packet loss. A vital element of end-to-end delay and delay jitter is the random queueing delays in network switches and routers. Analysis of robust mechanisms for buffer management at network routers needs to be carried out in order to reduce end-to-end delay for traffic generated by multimedia applications. In this context, a threshold based buffer management scheme for accommodating multiple class multimedia traffic in network routers has been analysed. This technique effectively controls the allocation of buffer to various traffic classes according to their delay constraints. The forms of the joint state probabilities, as well as basic performance measures such as blocking probabilities are analytically established at equilibrium. Typical numerical experiments are included to illustrate the credibility of the proposed mechanism in the context of different quality of service (QoS) grades for various network traffic classes. This model, therefore, can be used as a powerful tool to provide a required grade of service to a particular class of multimedia based web traffic in any heterogeneous network.     

A class-based scheme for E-commerce web servers: Formal specification and performance evaluation

This paper is an investigation into the performance of E-commerce applications. E-commerce has become one of the most popular applications of the web as a large population of web users is now benefiting from various on-line services including product searches, product purchases and product comparison. E-commerce provides users with 24-7 shopping facilities. However, the consequence of these benefits and facilities is the excessive load on E-commerce web servers and the performance degradation of E-commerce (eCom) requests they process. This paper addresses this issue and proposes a class-based priority scheme which classifies eCom requests into high and low priority requests. In E-commerce, some requests (e.g. payment) are generally considered more important than others (e.g. search or browse). We believe that by assigning class-based priorities at multiple service levels, E-commerce web servers can perform better and can improve the performance of high priority eCom requests. In this paper, we formally specify and implement the proposed scheme and evaluate its performance using multiple servers. Experimental results demonstrate that the proposed scheme significantly improves the performance of high priority eCom requests.