Vertical arrays of nanostructures (NSs) are emerging as promising platforms for probing and manipulating live mammalian cells. The broad range of applications requires different types of interfaces, but cell settling on NS arrays is not yet fully controlled and understood. Cells are both seen to deform completely into NS arrays and to stay suspended like tiny fakirs, which have hitherto been explained with differences in NS spacing or density. Here, a better understanding of this phenomenon is provided by using a model that takes into account the extreme membrane deformation needed for a cell to settle into a NS array. It is shown that, in addition to the NS density, cell settling depends strongly on the dimensions of the single NS, and that the settling can be predicted for a given NS array geometry. The predictive power of the model is confirmed by experiments and good agreement with cases from the literature. Furthermore, the influence of cell‐related parameters is evaluated theoretically and a generic method of tuning cell settling through surface coating is demonstrated experimentally. These findings allow a more rational design of NS arrays for the numerous exciting biological applications where the mode of cell settling is crucial. 相似文献
The present study attempts quantitative determination of changes in the morphological surface features viz. fractal dimension, lower and upper cut off length scale through Power Spectral Density analysis prior to and after irradiation of 100 KeV Ar+ ion beam at incidence angles of 0°, 40° and 60° on ZnO thin films. All the unirradiated and irradiated samples are subjected to photoelectrochemical characterization and a correlation between photoelectrochemical performance and morphological parameters is established. Sample irradiated at 40° angle at the fluence of 5 × 1016 ions/cm2 is found to possess maximum fractal dimension of 2.72, lower and upper cut off length scale of 3.16 nm and 63.00 nm respectively. This sample exhibits maximum photocurrent density of 3.19 mA/cm2 and applied bias photon-to-current efficiency of 1.12% at 1.23 V/RHE. Hydrogen gas collected for duration of 1 h for the same sample was ~4.83 mLcm?2. 相似文献
This case report details the multidisciplinary treatment of peripartum left iliac vein thrombosis using percutaneous catheter-directed urokinase thrombolysis and balloon thromboplasty. Enhanced chances for long-term patency and the normalization of venous function make these minimally invasive procedures accepted options for the treatment of iliofemoral deep venous thrombosis in selected peripartum patients. 相似文献
High nitrogen steels provide excellent mechanical properties and corrosion resistance but are prone to form precipitates which adversely affect the corrosion resistance and toughness. High nitrogen steel powders currently available in the market are not claimed to be precipitate free. It is critical to avoid these precipitates while retaining nitrogen in the dissolved form to realize the value of these powder alloys. However, retaining high level of dissolved nitrogen in steel powder during melt atomization process is very challenging. Instead, solid-state dissolution of nitrogen into the powder alloy followed by rapid cooling may provide a convenient approach to avoid precipitate formation compared to traditional melt processing. This study presents a solution treatment approach to achieve elevated dissolved nitrogen levels (~ 0.4 wt pct) in Fe–Mn–Cr powder alloy with negligible precipitation of nitrides. The influence of starting material, holding time, temperature and cooling rate on the resulting microstructure is presented. A fully austenite matrix with high dissolved nitrogen content resulted in powders with desired mechanical properties.
Eicosa-5,8,11,14-tetraynoic acid or arachidonic acid or no supplement (controls) was given orally to rats maintained on a
fat free diet and the fatty acid composition of total lipids of several organs determined. No changes were noted in the total
fatty acid concentrations of the organs examined in the various groups. A decrease in the amount of arachidonic acid, 22∶4ω6
and 22∶5ω6 (as percent of total fatty acids), and an increase in the amount of 20∶3ω6 and linoleate were observed in total
lipids of several organs. In the group receiving the arachidonate supplement, there was less linoleate and 20∶3ω6 and more
arachidonate than in the controls. Both eicosa-5,8,11,14-tetraynoic acid and arachidonate supplements resulted in a decrease
in 20∶3ω9 in most organs studied. Generally, the most marked changes were seen in liver but, of the other organs examined
(heart, kidney, testis, brain, and adrenals), only the adrenals failed to show any significant differences between the controls
and each of the two supplemented groups. Although the experimental conditions preclude conclusive interpretation of the changes
observed, it is suggested that eicosa-5,8,11,14-tetraynoic acid was effective in inhibiting the conversion of linoleate to
arachidonate and the conversion of arachidonate to 22∶4 and 22∶5. 相似文献
The use of polymeric materials for the administration of pharmaceuticals, and as biomedical devices has increased dramatically. This review focuses on synthetic biodegradable polymers of current interest for medical use, based on ester and anhydride bonds. Special attention is given to factors affecting biodegradation, including: polymer structure, morphology, molecular weight, radiation, and chemical treatment, as well as the effects of drugs and plasticizers added to the polymer mass. The toxicity and biocompatibility of the polymers and their current and future applications in medicine are also briefly reviewed. 相似文献
A novel perforated bipole trickle-bed electrochemical reactor is investigated for the electro-synthesis of alkaline peroxide.
The process uses a relatively simple cell configuration in which a single electrolyte flows with oxygen gas in a flow-by graphite
felt cathode, sandwiched between a micro-porous diaphragm and a perforated bipolar electrode plate. The graphite felt cathodes
are 120 mm high by 25 mm wide and have a thickness of 3.2 mm. The reactor is operated at current densities in the range 1–5 kA m−2, ca. 800 kPa (abs) pressure and temperature (In/Out) 20–45 °C with one and two-cells. The reactor shows good performance
(current efficiency ∼78% at 2 kA m−2 and a specific energy of 5 kWh per kg of peroxide generated) with peroxide concentrations from 0.02 to 0.15 M in 1 M NaOH. 相似文献
Informally stated, we present here a randomized algorithm that given black-box access to the polynomial f computed by an unknown/hidden arithmetic formula ? reconstructs, on the average, an equivalent or smaller formula \({\hat{\phi}}\) in time polynomial in the size of its output \({\hat{\phi}}\). Specifically, we consider arithmetic formulas wherein the underlying tree is a complete binary tree, the leaf nodes are labeled by affine forms (i.e., degree one polynomials) over the input variables and where the internal nodes consist of alternating layers of addition and multiplication gates. We call these alternating normal form (ANF) formulas. If a polynomial f can be computed by an arithmetic formula μ of size s, it can also be computed by an ANF formula ?, possibly of slightly larger size sO(1). Our algorithm gets as input black-box access to the output polynomial f (i.e., for any point x in the domain, it can query the black box and obtain f(x) in one step) of a random ANF formula ? of size s (wherein the coefficients of the affine forms in the leaf nodes of ? are chosen independently and uniformly at random from a large enough subset of the underlying field). With high probability (over the choice of coefficients in the leaf nodes), the algorithm efficiently (i.e., in time sO(1)) computes an ANF formula \({\hat{\phi}}\) of size s computing f. This then is the strongest model of arithmetic computation for which a reconstruction algorithm is presently known, albeit efficient in a distributional sense rather than in the worst case. 相似文献
Novel diamines such as N,N′-bis(aminoaryl)terephthalamido-2-carboxylic acids (BATCA), which contain primary amine, amide and carboxylic acid groups and are soluble in dilute aqueous NaOH solution, were synthesized by reacting aromatic diamines with trimellitic anhydride chloride in dimethylformamide. Poly(amide imide)s containing 3:1 ratio of amide:imide groups in the polymer chain were prepared by low temperature solution polymerization of BATCAs with isophthaloyl chloride or terephthaloyl chloride in dimethylformamide at 5-10 °C to form poly(amide amic acid)s, and followed by treating with a mixture of triethylamine and acetic anhydride. The PAIs were soluble in polar aprotic solvents like dimethylformamide, dimethylacetamide, dimethylsulphoxide and N-methylpyrrolidone, and have inherent viscosities in the range of 0.30-0.66 dL/g. The PAIs were characterized by IR, 1H NMR and 13C NMR techniques. Thermogravimetric analysis (TGA) has shown that the initial decomposition temperatures of the polymers are in the range of 250-440 °C, depending upon the structures of diamine and diacid chloride. The glass transition temperatures of the PAIs are in the range of 128-320 °C. The IDT and Tg values of the polymers containing terephthaloyl unit are higher by about 20-40 °C than those of the polymers with isophthaloyl unit. BATCA could be utilized for the preparation of thin film composite membranes having PAA/PAI barrier layer on PES by in situ interfacial polymerization with IPC/TPC/TMC. 相似文献