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排序方式: 共有105条查询结果,搜索用时 31 毫秒
1.
Coline Grisotto Janice Taïl Cynthia Planesse Nicolas Diotel Marie-Paule Gonthier Olivier Meilhac David Couret 《International journal of molecular sciences》2021,22(9)
Background: Stroke in context of type 2 diabetes (T2D) is associated with a poorer outcome than in non-diabetic conditions. We aimed at creating a new reproducible mouse model of stroke in impaired glucose tolerance conditions induced by high-fat diet. Methods: Adult C57BL6 mice were fed for 2 months with either normal diet (ND) or high-fat diet (HFD). We used a model of Middle Cerebral Artery Occlusion (MCAO) for 90 min. Oral Glucose Tolerance Test (OGTT) and Insulin Tolerance Test (ITT) were used to assess pre-diabetic status. Brain infarct volume, hemorrhagic transformation (HT) as well as systemic and cerebral inflammatory markers were evaluated. Results: HFD was associated with an increased body weight and glycemia following OGTT. The HFD group presented a significant increase in brain infarct volume (38.7 (IQR 30–46.7%) vs. 28.45 (IQR 21–30%); p = 0.016) and HT (HFD: 2 (IQR 1–5) vs. ND: 0 (IQR 0–1); p = 0.012) and higher levels of IL-6 and MCP-1 in infarcted hemisphere compared to the ND group. Conclusion: Two months of HFD in adult mice were sufficient to alter the lipid profile and the control of hyperglycemia. These metabolic perturbations were significantly associated with increased infarct volume and hemorrhagic complications. 相似文献
2.
Nguyen-Huy Dung Pardo Marie-Paule Dogguy.Smiri Leïla 《Materials Research Bulletin》1982,17(3):293-300
The Mn0.23Ga1.85S3 phase belongs to the solid solution , stable at low temperature in the Ga2S3MnS system. It is hexagonal superstructure of the wurtzite, with the Ga2S3α′ type (; Z = 6; space groupe P61 or P65). Its crystal structure has been refined by the least squares method to a final R = 0.06 with 323 independant reflections. This structure is closely related to Ga2S3 α described by Hahn and Frank, and differs only by the partial occupation of the vacant metal site of Ga2S3 by Mn atoms in statistical disorder. 相似文献
3.
A Sketch-Based Interface for Clothing Virtual Characters 总被引:5,自引:0,他引:5
Emmanuel Turquin Jamie Wither Laurence Boissieux Marie-Paule Cani John F. Hughes 《Computer Graphics and Applications, IEEE》2007,27(1):72-81
This interactive system for garment creation determines a garment's shape and how the character wears it based on a user-drawn sketch. The system then uses distances between the 2D garment silhouette and the character model to infer remaining distance variations in 3D 相似文献
4.
Satellite-based estimates of groundwater storage variations in large drainage basins with extensive floodplains 总被引:2,自引:0,他引:2
Frédéric Frappart Fabrice Papa Andreas Güntner Joecila Santos da Silva Frédérique Seyler William B. Rossow Marie-Paule Bonnet 《Remote sensing of environment》2011,115(6):1588-1594
This study presents monthly estimates of groundwater anomalies in a large river basin dominated by extensive floodplains, the Negro River Basin, based on the synergistic analysis using multisatellite observations and hydrological models. For the period 2003-2004, changes in water stored in the aquifer is isolated from the total water storage measured by GRACE by removing contributions of both the surface reservoir, derived from satellite imagery and radar altimetry, and the root zone reservoir simulated by WGHM and LaD hydrological models. The groundwater anomalies show a realistic spatial pattern compared with the hydrogeological map of the basin, and similar temporal variations to local in situ groundwater observations and altimetry-derived level height measurements. Results highlight the potential of combining multiple satellite techniques with hydrological modeling to estimate the evolution of groundwater storage. 相似文献
5.
We present a real-time method for sculpting triangular manifold meshes while enabling arbitrary surface deformation with seamless topological changes. Our insight is that the use of quasi-uniform mesh sampling, an interesting option now that very large meshes can be edited and displayed in real-time, provides the right framework for expressing and efficiently processing arbitrary changes of topological genus. The user controls deformation by gesture: he sweeps tools that apply a variety of deformation fields, from smoothing and trimming ones to local inflation and constant volume deformation tools. Meanwhile, the quasi-regular mesh seamlessly splits or locally blends when and where needed, while still following the user-specified deformation. Our method guarantees a closed, self-intersection-free mesh, whatever the user action. We demonstrate the practical usability of the resulting, interactive sculpting system through the sculpture of models that would have been extremely difficult to achieve with both current research methods and state of the art professional software. 相似文献
6.
7.
Dr. Mikayel Aznauryan Dr. Sofie Louise Noer Dr. Camilla W. Pedersen Dr. Jean-Louis Mergny Dr. Marie-Paule Teulade-Fichou Prof. Victoria Birkedal 《Chembiochem : a European journal of chemical biology》2021,22(10):1811-1817
Several small-molecule ligands specifically bind and stabilize G-quadruplex (G4) nucleic acid structures, which are considered to be promising therapeutic targets. G4s are polymorphic structures of varying stability, and their formation is dynamic. Here, we investigate the mechanisms of ligand binding to dynamically populated human telomere G4 DNA by using the bisquinolinium based ligand Phen-DC3 and a combination of single-molecule FRET microscopy, ensemble FRET and CD spectroscopies. Different cations are used to tune G4 polymorphism and folding dynamics. We find that ligand binding occurs to pre-folded G4 structures and that Phen-DC3 also induces G4 formation in unfolded single strands. Following ligand binding to dynamically populated G4s, the DNA undergoes pronounced conformational redistributions that do not involve direct ligand-induced G4 conformational interconversion. On the contrary, the redistribution is driven by ligand-induced G4 folding and trapping of dynamically populated short-lived conformation states. Thus, ligand-induced stabilization does not necessarily require the initial presence of stably folded G4s. 相似文献
8.
Dr. Laura Fourmois Dr. Florent Poyer Dr. Aude Sourdon Delphine Naud-Martin Dr. Sounderya Nagarajan Dr. Rahima Chennoufi Dr. Eric Deprez Dr. Marie-Paule Teulade-Fichou Dr. Florence Mahuteau-Betzer 《Chembiochem : a European journal of chemical biology》2021,22(14):2457-2467
Mitochondria are involved in many cellular pathways and dysfunctional mitochondria are linked to various diseases. Hence efforts have been made to design mitochondria-targeted fluorophores for monitoring the mitochondrial status. However, the factors that govern the mitochondria-targeted potential of dyes are not well-understood. In this context, we synthesized analogues of the TP-2Bzim probe belonging to the vinyltriphenylamine (TPA) class and already described for its capacity to bind nuclear DNA in fixed cells and mitochondria in live cells. These analogues ( TP-1Bzim, TPn-2Bzim, TP1+-2Bzim, TN-2Bzim ) differ in the cationic charge, the number of vinylbenzimidazolium branches and the nature of the triaryl core. Using microscopy, we demonstrated that the cationic derivatives accumulate in mitochondria but do not reach mtDNA. Under depolarisation of the mitochondrial membrane, TP-2Bzim and TP1+-2Bzim translocate to the nucleus in direct correlation with their strong DNA affinity. This reversible phenomenon emphasizes that these probes can be used to monitor ΔΨm variations. 相似文献
9.
Suzanne Barnier Micheline Guittard Marie-Paule Pardo Pierre Porcher Jacques Livage 《Materials Research Bulletin》1983,18(10):1217-1227
Preparation of glasses. Glass forming domains in the ternary systems [Ga2S3, (La2S3, La2O2S or La2O3), MnS]. Thermal behaviour. U.V. and visible spectroscopy. E.P.R. spectra. Manganese has an octahedral environment of sulfur. 相似文献
10.
Van der Waals versus dipolar forces controlling mesoscopic organizations of magnetic nanocrystals 总被引:2,自引:0,他引:2
The structure, thermodynamics and dynamics in many physical and chemical systems are determined by interplay of short-range isotropic and long-range anisotropic forces. Magnetic nanoparticles dispersed in solution are ideal model systems to study this interplay, as they are subjected to both isotropic van der Waals and anisotropic dipolar forces. Here we show from experiment an abrupt transition of maghemite nanocrystal organization from chain-like to random structures when nanoparticle solutions are evaporated under a magnetic field. This is explained by brownian dynamics simulations in terms of a variation of the strength of van der Waals interactions with the particle contact distance, which is tuned by the length of the molecules coating the particles. The weak dipole-dipole interactions between the maghemite particles are usually not sufficient to result in the chain formation observed here. However, due to the van der Waals interactions, when the nanocrystal contact distance is short enough, clusters of nanocrystals are formed during the evaporation process. These clusters exhibit large dipole moments compared with a single particle, which explains the formation of chain-like structures. Conversely, when the nanocrystal contact distance is too long, no nanocrystal aggregation occurs, and a random distribution of maghemite nanocrystals is obtained. 相似文献