Two new Protecting Groups for the Guanidino Function of arginine

Two new synthons, Fmoc-L-Arg(biphenyl-4-sulphonyl)-OH ( 8 ) and Fmoc-Arg(4-methoxy-3-t-butylbenzenesulphonyl)-OH ( 14 ), are prepared for the synthesis of arginine-containing peptides. These groups are cleaved by commonly employed trifluoroacetic acid and methanesulphonic acid. Kinetic studies reveal that extended bicyclic aromatic conjugation, as in biphenyl, slightly improves the acid lability compared to the electron-donating t-butyl group.     

A Fused Machine Learning Approach for Intrusion Detection System

The rapid growth in data generation and increased use of computer network devices has amplified the infrastructures of internet. The interconnectivity of networks has brought various complexities in maintaining network availability, consistency, and discretion. Machine learning based intrusion detection systems have become essential to monitor network traffic for malicious and illicit activities. An intrusion detection system controls the flow of network traffic with the help of computer systems. Various deep learning algorithms in intrusion detection systems have played a prominent role in identifying and analyzing intrusions in network traffic. For this purpose, when the network traffic encounters known or unknown intrusions in the network, a machine-learning framework is needed to identify and/or verify network intrusion. The Intrusion detection scheme empowered with a fused machine learning technique (IDS-FMLT) is proposed to detect intrusion in a heterogeneous network that consists of different source networks and to protect the network from malicious attacks. The proposed IDS-FMLT system model obtained 95.18% validation accuracy and a 4.82% miss rate in intrusion detection.     

Ensemble Machine Learning Based Identification of Pediatric Epilepsy

Epilepsy is a type of brain disorder that causes recurrent seizures. It is the second most common neurological disease after Alzheimer’s. The effects of epilepsy in children are serious, since it causes a slower growth rate and a failure to develop certain skills. In the medical field, specialists record brain activity using an Electroencephalogram (EEG) to observe the epileptic seizures. The detection of these seizures is performed by specialists, but the results might not be accurate due to human errors; therefore, automated detection of epileptic pediatric seizures might be the optimal solution. This paper investigates the detection of epileptic seizures by applying supervised machine learning techniques. The techniques applied on the data of patients with ages seven years and below from children’s hospital boston massachusetts institute of technology (CHB-MIT) scalp EEG database of epileptic pediatric signals. A group of Naïve Bayes (NB), Support vector machine (SVM), Logistic regression (LR), k-nearest neighbor (KNN), Linear discernment (LD), Decision tree (DT), and ensemble learning methods were applied to the classification process. The results demonstrated the outperformance of the present study by achieving 100% for all parameters using the Ensemble learning model in contrast to state-of-the-art studies in the literature. Similarly, the SVM model achieved performance with 98.3% for sensitivity, 97.7% for specificity, and 98% for accuracy. The results of the LD and LR models reveal the lower performance i.e., the sensitivity at 66.9%–68.9%, specificity at 73.5%–77.1%, and accuracy at 70.2%–73%.     

A Neuro-Fuzzy Approach to Road Traffic Congestion Prediction

The fast-paced growth of artificial intelligence applications provides unparalleled opportunities to improve the efficiency of various systems. Such as the transportation sector faces many obstacles following the implementation and integration of different vehicular and environmental aspects worldwide. Traffic congestion is among the major issues in this regard which demands serious attention due to the rapid growth in the number of vehicles on the road. To address this overwhelming problem, in this article, a cloud-based intelligent road traffic congestion prediction model is proposed that is empowered with a hybrid Neuro-Fuzzy approach. The aim of the study is to reduce the delay in the queues, the vehicles experience at different road junctions across the city. The proposed model also intended to help the automated traffic control systems by minimizing the congestion particularly in a smart city environment where observational data is obtained from various implanted Internet of Things (IoT) sensors across the road. After due preprocessing over the cloud server, the proposed approach makes use of this data by incorporating the neuro-fuzzy engine. Consequently, it possesses a high level of accuracy by means of intelligent decision making with minimum error rate. Simulation results reveal the accuracy of the proposed model as 98.72% during the validation phase in contrast to the highest accuracies achieved by state-of-the-art techniques in the literature such as 90.6%, 95.84%, 97.56% and 98.03%, respectively. As far as the training phase analysis is concerned, the proposed scheme exhibits 99.214% accuracy. The proposed prediction model is a potential contribution towards smart cities environment.     

Supervised Machine Learning-Based Prediction of COVID-19

COVID-19 turned out to be an infectious and life-threatening viral disease, and its swift and overwhelming spread has become one of the greatest challenges for the world. As yet, no satisfactory vaccine or medication has been developed that could guarantee its mitigation, though several efforts and trials are underway. Countries around the globe are striving to overcome the COVID-19 spread and while they are finding out ways for early detection and timely treatment. In this regard, healthcare experts, researchers and scientists have delved into the investigation of existing as well as new technologies. The situation demands development of a clinical decision support system to equip the medical staff ways to timely detect this disease. The state-of-the-art research in Artificial intelligence (AI), Machine learning (ML) and cloud computing have encouraged healthcare experts to find effective detection schemes. This study aims to provide a comprehensive review of the role of AI & ML in investigating prediction techniques for the COVID-19. A mathematical model has been formulated to analyze and detect its potential threat. The proposed model is a cloud-based smart detection algorithm using support vector machine (CSDC-SVM) with cross-fold validation testing. The experimental results have achieved an accuracy of 98.4% with 15-fold cross-validation strategy. The comparison with similar state-of-the-art methods reveals that the proposed CSDC-SVM model possesses better accuracy and efficiency.     

Modelling and Simulation of COVID-19 Outbreak Prediction Using Supervised Machine Learning

Novel Coronavirus-19 (COVID-19) is a newer type of coronavirus that has not been formally detected in humans. It is established that this disease often affects people of different age groups, particularly those with body disorders, blood pressure, diabetes, heart problems, or weakened immune systems. The epidemic of this infection has recently had a huge impact on people around the globe with rising mortality rates. Rising levels of mortality are attributed to their transmitting behavior through physical contact between humans. It is extremely necessary to monitor the transmission of the infection and also to anticipate the early stages of the disease in such a way that the appropriate timing of effective precautionary measures can be taken. The latest global coronavirus epidemic (COVID-19) has brought new challenges to the scientific community. Artificial Intelligence (AI)-motivated methodologies may be useful in predicting the conditions, consequences, and implications of such an outbreak. These forecasts may help to monitor and prevent the spread of these outbreaks. This article proposes a predictive framework incorporating Support Vector Machines (SVM) in the forecasting of a potential outbreak of COVID-19. The findings indicate that the suggested system outperforms cutting-edge approaches. The method could be used to predict the long-term spread of such an outbreak so that we can implement proactive measures in advance. The findings of the analyses indicate that the SVM forecasting framework outperformed the Neural Network methods in terms of accuracy and computational complexity. The proposed SVM system model exhibits 98.88% and 96.79% result in terms of accuracy during training and validation respectively.     

Aspect Level Songs Rating Based Upon Reviews in English

With the advancements in internet facilities, people are more inclined towards the use of online services. The service providers shelve their items for e-users. These users post their feedbacks, reviews, ratings, etc. after the use of the item. The enormous increase in these reviews has raised the need for an automated system to analyze these reviews to rate these items. Sentiment Analysis (SA) is a technique that performs such decision analysis. This research targets the ranking and rating through sentiment analysis of these reviews, on different aspects. As a case study, Songs are opted to design and test the decision model. Different aspects of songs namely music, lyrics, song, voice and video are picked. For the reason, reviews of 20 songs are scraped from YouTube, pre-processed and formed a dataset. Different machine learning algorithms—Naïve Bayes (NB), Gradient Boost Tree, Logistic Regression LR, K-Nearest Neighbors (KNN) and Artificial Neural Network (ANN) are applied. ANN performed the best with 74.99% accuracy. Results are validated using K-Fold.