The Expression of TNF-α and ICAM-1 in Lesions of Lichen Planus and Its Implication

In order to investigate the role of TNF-α and ICAM-1 in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of TNF-α and ICAM-1 in skin le- sions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rates of TNF-α and ICAM-1 expressions in lichen planus were significantly higher than those in normal skins (both P<0.05). Meanwhile, there was a obvious correlation between the in- crease of TNF-α and that of ICAM-1 in lichen planus. The expression of TNF-α and ICAM-1 might play an important role in the development of lichen planus.     

寻常型银屑病皮损中Th17细胞相关因子的表达

目的:研究Th17细胞相关因子在银屑病发病机制中的作用.方法:用逆转录-聚合酶链反应法(RT-PCR)半定量分析寻常型银屑病患者皮损区、非皮损区及正常人皮肤组织中Th17细胞相关因子IL-17和IL-23(p19/p40)、IL-6 mRNA的表达.结果:银屑病患者皮损中IL-17、IL-23p19、IL-23p40和IL-6的 mRNA平均相对表达量分别为1.231±0.843、1.166±0.142、1.125±0.104和1.186±0.222.皮损组织中该4种细胞因子mRNA表达水平均高于非皮损组和正常皮肤组,非皮损组四者表达高于正常对照组,差异均有统计学意义(均P<0.05).结论:Th17细胞相关因子在银屑病患者皮损中过度表达,提示Th17型细胞因子在银屑病的免疫发病机制中可能起着非常重要的作用.     

TNF-α、ICAM-1在扁平苔藓皮损中的表达

目的:检测TNF-α和ICAM-1在扁平苔藓皮损中的表达。方法:采用免疫组化SP法检测肿瘤坏死因子α(TNF-α)和细胞间黏附分子-1(ICAM-1)在29例扁平苔藓和10例正常人皮肤中的表达水平。结果:扁平苔藓皮损中TNF-α和ICAM-1的表达水平显著高于正常人对照组(P<0.05)。TNF-α和ICAM-1的表达呈正相关(r=0.526,P<0.05)。结论:TNF-α和ICAM-1异常高表达可能与扁平苔藓的发病有关。     

梭形细胞血管内皮瘤

报告1例梭形细胞血管内皮瘤.患者男,16岁.右跖部结节10余年,相继波及左足和双小腿下段,无自觉症状.皮损组织病理检查可见真皮中下层由海绵状血管腔隙和梭形细胞组成的团块.依据临床表现和组织病理学改变,诊断为梭形细胞血管内皮瘤.     

贵州地区369例泌尿生殖道支原体感染及药敏分析

目的了解贵州地区泌尿生殖道支原体感染情况及耐药性,指导临床用药。方法对369例门诊病例的泌尿生殖道分泌物进行培养和药敏试验。结果泌尿生殖道支原体感染率为37.13%,其中女性患者阳性率（48.87%）高于男性患者（30.51%）;在支原体阳性病例中,解脲脲原体（Uu）的病原构成比为61.31%,单纯人型支原体（Mh）感染构成比为8.03%。混合感染（Uu＋Mh）构成比为30.66%,支原体感染以20~50岁为主,占96.35%。药敏试验显示支原体对交沙霉素、美满霉素、强力霉素较敏感。结论贵州地区泌尿生殖道支原体感染以Uu为主,治疗首选交沙霉素、美满霉素、强力霉素。     

Selective Expression of Progesterone Receptor in Malignant Melanoma Was Inversely Correlated with PCNA

To investigate the role of progesterone receptor （PR） expression in malignant melanoma （MM）, PR and proliferative cell nuclear antigen （PCNA） expression were immunohistochemistrically evaluated in a series of 35 specimens of MM, and the correlation between the immunohistochemistrical findings and clinicopathological data was also analyzed. PR expression was detected in 25.7% （9/35） of the patients with MM. No PR expression was observed in nevi. PR expression was inversely correlated with PCNA expression （r=-0.353, P=-0.026）. PR expression was slightly increased in females, subjects aged under 55 y, those with ulceration, non-acral subtype and diagnosis delay longer than 1 y, but the difference was not statistically significant. Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth.     

嗜酸性筋膜炎1例

1 病历摘要 患者男,59岁.因右前臂进行性肿胀、变硬3个月.于2007年3月15日来我院门诊就诊.2006年12月患者自觉右前臂远端皮肤肿胀、发红,微痒,无发热、疼痛.给予抗生素静脉滴注1周,效果不佳.10 d前皮损波及手背,手背红肿发硬,不能捏起,腕关节活动受限,握拳困难,遂来我院就诊.发病前皮损部位无外伤史.否认既往有系统性疾病及药物过敏史.     

Expression of Apoptosis Related Protein in Skin Lesions of Lichen Planus and Its Implication

In order to investigate the role of Caspase-3 and Bax in the pathogenesis of lichen planus, immunohistochemistry was used to detect the expression of Caspase-3 and Bax in skin lesions of the patients with lichen planus and skin tissues of normal subjects. The results showed that positive rate of Caspase-3 and Bax expression in lichen planus were significantly higher than that in normal skins （both P〈0.05）. Meanwhile, there was a obvious correlation between the increase of Caspase-3 and that of Bax in lichen planus. The expression of Caspase-3 and Bax might play an important role in the development of lichen planus.     

扁平苔藓皮损中caspase-3和Bax蛋白的表达

目的 探讨凋亡相关蛋白半胱氨酸天冬氨酸蛋白酶-3(caspase-3)和Bax在扁平苔藓皮损中的表达及其意义.方法 采用免疫组化SP法对29例扁平苔藓患者皮损组织和10例正常人皮肤组织中caspase-3和Bax的表达进行检测.结果 扁平苔藓皮损组织中caspase-3和Bax蛋白表达水平均明显高于正常皮肤组织,组间比较差异均有统计学意义(均P＜0.01).而且caspase-3蛋白表达与Bax的表达有显著相关性(P＜0.05).结论 Caspase-3和Bax可能通过诱导扁平苔藓皮损处角质形成细胞的凋亡而参与扁平苔藓的发病.