Computational models of myocardial endomysial collagen arrangement

Collagen extracellular matrix is one of the factors related to high passive stiffness of cardiac muscle. However, the architecture and the mechanical aspects of the cardiac collagen matrix are not completely known. In particular, endomysial collagen contribution to the passive mechanics of cardiac muscle as well as its micro anatomical arrangement is still a matter of debate. In order to investigate mechanical and structural properties of endomysial collagen, we consider two alternative computational models of some specific aspects of the cardiac muscle. These two models represent two different views of endomysial collagen distribution: (1) the traditional view and (2) a new view suggested by the data obtained from scanning electron microscopy (SEM) in NaOH macerated samples (a method for isolating collagen from the other tissue). We model the myocardial tissue as a net of spring elements representing the cardiomyocytes together with the endomysial collagen distribution. Each element is a viscous elastic spring, characterized by an elastic and a viscous constant. We connect these springs to imitate the interconnections between collagen fibers. Then we apply to the net of springs some external forces of suitable magnitude and direction, obtaining an extension of the net itself. In our setting, the ratio forces magnitude /net extension is intended to model the stress /strain ratio of a microscopical portion of the myocardial tissue. To solve the problem of the correct identification of the values of the different parameters involved, we use an artificial neural network approach. In particular, we use this technique to learn, given a distribution of external forces, the elastic constants of the springs needed to obtain a desired extension as an equilibrium position. Our experimental findings show that, in the model of collagen distribution structured according to the new view, a given stress /strain ratio (of the net of springs, in the sense specified above) is obtained with much smaller (w.r.t. the other model, corresponding to the traditional view) elasticity constants of the springs. This seems to indicate that by an appropriate structure, a given stiffness of the myocardial tissue can be obtained with endomysial collagen fibers of much smaller size.     

HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals

HIV-specific mucosal and cellular immunity was analyzed in heterosexual couples discordant for HIV status in serum and in HIV-unexposed controls. HIV-specific IgA but not IgG was present in urine and vaginal wash samples from HIV-exposed seronegative individuals (ESN), whereas both IgA and IgG were observed in their HIV-seropositive partners; antibodies were not detected in low-risk controls. Envelope protein (Env) peptide-stimulated interleukin-2 (IL-2) production by peripheral blood mononuclear cells (PBMCs) was detected in 9 out of 16 ESNs, 5 out of 16 HIV-infected patients and 1 out of 50 controls. Env peptide-stimulated PBMCs of ESNs produced more IL-2 and less IL-10 compared with those of HIV-infected individuals; no differences were observed in chemokine production or in CCR5 expression. These data demonstrate that a compartmentalized immune response to pathogens is possible in humans and raise the possibility of protective roles for cell-mediated immunity and mucosal IgA in HIV-seronegative individuals exposed to HIV.     

A three-loop antenna system for performing near-field measurementsof electric and magnetic fields from video display terminals

This paper discusses the use of a three-loop antenna system (TLAS) for near-field measurement of electric and magnetic fields from video display terminals (VDTs). We calculated the electric and magnetic dipole moments to derive the electric and magnetic field patterns in the near field region. Electric and magnetic fields, emitted by several different models of VDTs, were evaluated with the TLAS and were compared with those measured by conventional electric and magnetic field probes at different distances and directions from VDTs. A good correlation (±1.6 dB) between the two measurement techniques was found. This agreement is within the accuracy (±2 dB) of the conventional field probe measurements     

Graft copolymers of lignin from straw with 1‐ethenylbenzene: Synthesis and characterization

The synthesis of copolymers between lignin from steam‐exploded straw and 1‐ethenylbenzene is described. Beforehand, lignin from steam‐exploded straw was fully characterized by using elemental analysis, ultraviolet spectroscopy, gel permeation chromatography (GPC), Fourier transform infrared (FTIR), and both ¹H and ¹³C nuclear magnetic resonance (NMR) spectroscopy. Using a previously described procedure utilizing calcium chloride and hydrogen peroxide as reagents the synthesis of the copolymers was performed. FTIR of the copolymers showed the presence of both lignin and polystyrene. GPC analysis showed the presence of a fraction with high molecular weights. These results were confirmed from both viscosity data and differential calorimetry. © 2000 John Wiley & Sons, Inc. J Appl Polym Sci 79: 72–79, 2001     

Persistent Scatterers Interferometry Hotspot and Cluster Analysis (PSI-HCA) for detection of extremely slow-moving landslides

The synthetic aperture radar (SAR) interferometry (InSAR) technique has already shown its importance in landslide mapping and monitoring applications. However, the usefulness of traditional differential InSAR applications is limited by disturbing factors such as temporal decorrelation and atmospheric disturbances. The Persistent Scatterers Interferometry (PSI) technique is a recently developed InSAR approach. It generates stable radar benchmarks (namely persistent scatterers, PSI point targets) using a multi-interferogram analysis of SAR images. The PSI technique has the advantage of reducing temporal decorrelation and atmospheric artefacts. The PSI technique is suitable for the investigation of extremely slow-moving landslides due to its capability to detect ground displacements with millimetre precision. However, the interpretation of PSI outputs is sometimes difficult for the large number of possible persistent scatterers (PSs). A new approach of PSI Hotspot and Cluster Analysis (PSI-HCA) is introduced here in order to develop a procedure for mapping landslides efficiently and automatically. This analysis has been performed on PSs in hilly and mountainous areas within the Arno river basin (Italy). The aim is to use PSs processed from 4 years (2003–2006) of Radarsat images for identifying areas preferentially affected by extremely slow-moving landslides. The Getis–Ord G_i *?statistic is applied in the study for the PSI-HCA approach. The velocity of PSs is used as weighting factor and the G_i *?index is calculated for each single point target. The results indicate that both high positive and low negative G_i *?values imply the clustering of potential mass movements. High positive values suggest the moving direction towards the sensor along the satellite line-of-sight (LOS), whereas low negative values imply the movement away from the sensor. Furthermore, the kernel function is used to estimate PS density based on these derived G_i *?values. The output is a hotspot map which highlights active mass movements. This spatial statistic approach of PSI-HCA is considered an effective way to extract useful information from PSs at a regional scale, thus providing an innovative approach for rapid mapping of extremely slow-moving landslides over large areas.     

Platinum compounds as radiosensitizers in strontium-89 metabolic radiotherapy

PURPOSE: Strontium-89 is currently used for the treatment of painful bone metastases. This study reports on two preliminary experiences with low-dose platinum compounds, carboplatin and cisplatin, as radiosensitizers in 89Sr therapy. PATIENTS AND METHODS: 30 patients entered the carboplatin study: 15 patients (Group A) were treated with 148 MBq 89Sr followed by carboplatin (100 mg/m2 at 7 and 21 days) and 15 patients (Group B) were treated with 89Sr alone. 12 patients entered the cisplatin study: six patients (Arm 1) received 148 Mq 89Sr plus cisplatin (50 mg/m2) in two administrations (immediately before and 10 days after 89Sr injection) and six patients (Arm 2) received 89Sr plus two placebo administrations. Pain response was assessed 8 weeks after the therapy on the Wisconsin score modifications. RESULTS: No clinically significant adverse effects or myelosuppression by platinum compounds were observed. In carboplatin study a pain response was observed in 20 of 27 (74%) evaluable patients, 13/15 in group A and 7/12 in group B. The pain response in the patients treated with 89Sr and carboplatin was clearly superior to that seen in the patients treated with 89Sr alone (P = 0.025), whereas survival was only marginally better in the combined treatment group (8.1 vs 5.7 months, P = 0.19). In cisplatin study a pain response was observed in 10 of 12 (83%) evaluable patients, 5/6 in Arm 1 and 4/6 in Arm 2. CONCLUSIONS: Low-dose platinum compounds seem to enhance the effects of 89Sr radioisotope therapy on pain from bone metastases without relevant hematological toxicity.     

Dental radiology dosimetric data as routinely collected in an Italian hospital

The work presented here was developed in the framework of the SENTINEL Project and is devoted to the analysis of dental radiology dosimetric data. The procedure of data processing allows the analysis of some important aspects related to the protection of the patient and the staff because of the position of the operators near the patient and their exposure to the radiation scattered by the patient. Dental radiology data was collected in an Italian hospital. Following the Italian quality assurance (QA) protocols and suggestions by the leaders of the SENTINEL Project, X-ray equipment performances have been analysed in terms of: kVp accuracy, exposure time accuracy and precision, tube output, dose reproducibility and linearity, beam collimation, artefacts and light tightness. Referring to these parameters the physical quality index (QI) was analysed. In a single numerical value between 0 and 1, QI summarises the results of quality tests for radiological devices. The actual impact of such a figure (as suggested by international QA protocols or as adopted by local QA routine) on the policy of machine maintenance and replacement is discussed.     

Geotechnical and hydrological characterization of hillslope deposits for regional landslide prediction modeling

Bulletin of Engineering Geology and the Environment - We attempt a characterization of the geotechnical and hydrological properties of hillslope deposits, with the final aim of providing reliable...     

A time-domain method for characterizing the reflection coefficientof absorbing materials from 30 to 1000 MHz

A wideband time-domain reflectometer is used to evaluate the reflection characteristics of RF/microwave absorbers. The reflectometer uses an array of two identical broadband antennas (both transmitting and receiving). The two antennas are used in a difference mode to remove the undesired signals and enhance the small reflections being measured. Using this technique, one can separate the target surface reflection from those generated outside the target area. The bandwidth of the pulses is 30 to 1000 MHz, and the reflection coefficient is measured over this range. The method has been used to characterize the reflectivity of three different types of absorber placed in an anechoic chamber. The results are reported together with a discussion of the main sources of errors