Review of The Robot's Rebellion: Finding Meaning in the Age of Darwin.

Review of book The Robot's Rebellion: Finding Meaning in the Age of Darwin by Keith E. Stanovich (see record 2004-95228-000). In his interesting scholarly book, The Robot's Rebellion, Stanovich leads us on a journey to find meaning in a world populated by mortal biological vehicles, the robots, put on earth to replicate their masters' selfish genes. If the genes do a satisfactory job programming the robots, then the genes replicate in perpetuity and are, therefore, immortal. Stanovich's basic assumptions are: a) vehicles are designed to replicate genes; b) at least in human animals, the brain houses two minds; c) the first mind, System 1 or The Autonomous Set of Systems, evolved much earlier in evolutionary history than did the second mind, System 2 or the Analytic System; d) System 1 is associative, parallel, fast to respond, and designed to automatically serve its genetic master; e) System 2 is rule-based, serial, slow to respond, not aware of System 1 functioning but sometimes privy to System 1 output, controls executive functioning, and is capable of self-evaluation and leading the rebellion against its genetic master; and, f) memes, culturally generated ideas passed on by nongenetic means, can sometimes be as effective as System 1 at squashing the rebellion. These assumptions are derived from work in cognitive science and evolutionary biology, and provide a solid foundation for the book. Both the metaphor and the basic assumptions are embedded in detailed and informative reviews of decision theory, evolutionary psychology, memetic theory, rational philosophy, and utility theory. The interweaving of metaphor and review provides a framework that allows Stanovich to make inferences to help the general reader understand "the implications of modern science" (p. xi). He also develops criteria to evaluate memes that are needed in his quest to find meaning in human existence. In combination with the basic assumptions, these criteria are used to create an ethical ideology that will be embraced by some readers. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Lymphocyte subset profile of young healthy children residing in a rural area: possible role of recurrent gastrointestinal infections

BACKGROUND: Lymphocyte subsets in healthy children are currently characterized by age-related standards. Because antigenic stimuli play a role in maturation of the immune system after birth, there is a question of whether cellular immune development differs in infants whose living conditions entail extensive antigenic exposure and infants growing up in a more protected environment. METHODS: Peripheral blood lymphocyte subsets were studied in two populations of children of similar age and nutritional status; children belonging to a rural population residing in proximity with farm animals and children from an economically privileged urban population. In each population, children studied included a group with an acute diarrheal episode and a healthy control group. RESULTS: Among rural population children, 65% had experienced at least one episode of gastroenteritis within the previous 3-month-period, compared with less than 10% of urban population children. In the rural population group 15% had experienced two or more episodes of gastroenteritis. The proportion of helper T cells was similar in rural population and urban population children. Among helper T cells, the proportion of CD29+ "memory" cells of the total CD4+ helper T cells was more than two times higher than those in rural population children. The proportion of CD8 cells was higher in rural population children than in urban population children, and the proportion of natural killer cells, CD56+ and CD57+, was two to three times higher in rural population children. Within each population, peripheral blood lymphocyte subsets did not differ between the healthy control group and those with acute diarrhea. CONCLUSIONS: In young children exposure to environmental pathogens and specifically to gastrointestinal antigenic stimuli is a major factor affecting development of the cellular immune response. Young children who have experienced enhanced infectious exposure have a peripheral blood lymphocyte profile similar to that of adults.     

Effect of plasma TNF-alpha on filgrastim-stimulated hematopoiesis in mice and humans

Marshall syndrome is a rare, autosomal dominant skeletal dysplasia that is phenotypically similar to the more common disorder Stickler syndrome. For a large kindred with Marshall syndrome, we demonstrate a splice-donor-site mutation in the COL11A1 gene that cosegregates with the phenotype. The G+1-->A transition causes in-frame skipping of a 54-bp exon and deletes amino acids 726-743 from the major triple-helical domain of the alpha1(XI) collagen polypeptide. The data support the hypothesis that the alpha1(XI) collagen polypeptide has an important role in skeletal morphogenesis that extends beyond its contribution to structural integrity of the cartilage extracellular matrix. Our results also demonstrate allelism of Marshall syndrome with the subset of Stickler syndrome families associated with COL11A1 mutations.     

Surgical treatment of the massively dilated ureter in children. Part II. Management by primary reconstruction

Bypass of the left ventricle was accomplished in dogs and the entire circulation was supported temporarily by only the right ventricle. The atrial septum was excised, and the atrium was repartitioned so that the pulmonary veins were in continuity with the right ventricle and the venae cavae were connected through the atrium. Anastomosis of the superior vena cava to the right pulmonary artery brought systemic venous return directly to the lungs. The main pulmonary artery was ligated proximal to the bifurcation, preserving distal confluence of right and left pulmonary arteries. A tubular prosthesis between the proximal pulmonary artery and the aorta connected the right ventricle to the systemic circuit. This procedure, or some modification of the principle, may have clinical feasibility in the treatment of patients with hypoplastic left heart syndrome.     

Saturated spectroscopy applied to Xenon at 3.5 µm

We report the observation of the xenon isotope spectrum using saturation spectroscopy on a gain cell external to a He-Xe laser. Six resonances centered about 3.508μm are observed over the limited tuning range of the laser. These resonances are assigned to the Xe¹²⁸Xe¹³⁰Xe¹³¹Xe¹³²Xe¹³⁴and Xe¹³⁶isotopes. The observed homogeneous linewidth is 9 ± 1 MHz, and the pressure broadening of the homogeneous linewidth is experimentally determined to be 71 ± 20 MHz/ torr.     

Weighing the Universe and its smallest constituents

The masses of both the neutrino and the Universe are derived from a mutually consistent set of equations in which the neutrino is coupled to the ground state of the Universe. A mass of m_v<10^-69 kg (energy equivalent ~10^-33 eV) is found for the neutrino. The equations yield a mass M~10⁵⁴ kg (~5×10⁸⁰ proton masses) for the Universe. It is found that the Universe is a black hole. Possible solutions of the missing solar neutrino flux problem are discussed. Interpretations of Planck's constant and the Planck mass are also found. The Planck mass appears to be about the largest single-particle mass which can exhibit quantum mechanical effects. The approach used is the only one that yields both the neutrino mass and the Universe mass, the smallest and largest masses, as a consistent solution of the same set of fundamental equations     

Hypertensive vascular disease as a cause of death in blacks versus whites: autopsy findings in 587 adults

Cardiovascular disease is the major cause of excess mortality among urban US blacks, but autopsy data comparing black-white differences in underlying pathological causes of cardiovascular death are lacking. We reviewed all 720 adult cases autopsied in 1991 in the New York City Medical Examiner's Office in which the coded cause of death was cardiovascular disease (International Classification of Diseases, 9th Revision, codes 391, 393 to 398, 401 to 404, 410, 411, 414 to 417, 420 to 438, and 440 to 444). After exclusion of 133 cases because race was missing or coded as other than black or white, gender was not coded, or there was an unusual circumstances of death or extreme obesity, 587 cases were available for analysis. There were 314 black and 273 white subjects. Black women were younger than white women at time of death (mean age, 54.7 versus 61.5 years; P<.001), whereas black and white men did not differ in mean age at death. Hypertensive vascular disease was the autopsy cause of death in 42% of blacks compared with 23% of whites (P<.001). Conversely, atherosclerotic heart disease was the autopsy cause of death in 64% of white subjects but only 38% of blacks. These patterns were consistent in both sexes and after adjustment for age. Hypertensive vascular disease was far more common than atherosclerotic heart disease as the cause of death at autopsy among blacks compared with whites in New York City, whereas atherosclerotic heart disease was more common in whites. These findings suggest that ineffective control of hypertension is a major factor contributing to excess cardiovascular mortality among urban blacks.     

Use and maintenance of strategies: The influence of accessibility to knowledge.

Conducted 2 experiments in which the interaction between strategy use and accessibility to relevant knowledge was investigated. Ss were asked to memorize a list of categorizable words, and use of a categorization strategy was assessed. Typicality of the category exemplars was varied in a between-Ss fashion to manipulate accessibility to relevant knowledge and the S's experience with the strategy. Ss were then given a 2nd list of categorizable words to memorize, and the use of a categorization strategy was again assessed. In Exp 2, attributional data regarding strategy use were also collected. Results from the 2 experiments show that variations in accessibility to knowledge have a significant effect on strategy use on the 1st memorization trial. Experiencing highly typical items on the 1st list was found to be associated with continued use of the strategy on the 2nd list (i.e., ease of use on the 1st trial affected maintenance of the strategy). (PsycINFO Database Record (c) 2010 APA, all rights reserved)