A study on micro machining of e-glass–fibre–epoxy composite by ECSM process

The paper presents the result of an experimental investigation on the micro machining of electrically non-conductive e-glass–fibre–epoxy composite during electrochemical spark machining using specially designed square cross section with centrally micro hole brass tool and different diameter round-shaped micro tools made of IS-3748 steel. A micro electrochemical spark machining (ECSM) setup has been designed, fabricated and used for conducting the experiments. According to the Taguchi method-based design, the specific numbers of experiments have been carried out to investigate the influence of the fabricated ECSM parameters on the material removal rate and overcut on generated hole radius. Test results show that the material removal rate is maximum when machining was performed at higher setting value of D.C. supply voltage (e.g. 70?V), moderate setting value of electrolytic concentration (e.g. 80?g/l) and 180-mm gap between electrodes. Taking significant machining parameters into consideration and using multiple linear regression, mathematical modes for material removal rate and overcut on hole radius are established to investigate the influence of cutting parameters during micro-ECSM. The influence of machining parameters on machined hole and special shape contour quality are also analysed through different scanning electron micrographs. Confirmation test results established the fact that the developed mathematical models are appropriate for effectively representing the machining performance criteria.     

Reduced Maternal Erythrocyte Long Chain Polyunsaturated Fatty Acids Exist in Early Pregnancy in Preeclampsia

The present prospective study examines proportions of maternal erythrocyte fatty acids across gestation and their association with cord erythrocyte fatty acids in normotensive control (NC) and preeclamptic pregnancies. We hypothesize that maternal fatty acid status in early pregnancy influences fetal fatty acid stores in preeclampsia. 137 NC women and 58 women with preeclampsia were included in this study. Maternal blood was collected at 3 time points during pregnancy (16–20th weeks, 26–30th weeks and at delivery). Cord blood was collected at delivery. Fatty acids were analyzed using gas chromatography. The proportions of maternal erythrocyte α‐linolenic acid, docosahexaenoic acid, nervonic acid, and monounsaturated fatty acids (MUFA) (p < 0.05 for all) were lower while total n‐6 fatty acids were higher (p < 0.05) at 16–20th weeks of gestation in preeclampsia as compared with NC. Cord 18:3n‐3, 22:6n‐3, 24:1n‐9, MUFA, and total n‐3 fatty acids (p < 0.05 for all) were also lower in preeclampsia as compared with NC. A positive association was observed between maternal erythrocyte 22:6n‐3 and 24:1n‐9 at 16–20th weeks with the same fatty acids in cord erythrocytes (p < 0.05 for both) in preeclampsia. Our study for the first time indicates alteration in maternal erythrocyte fatty acids at 16th weeks of gestation which is further reflected in cord erythrocytes at delivery in preeclampsia.     

Tunable Thermoelectric Performance in Porous Armchair Graphene Nanoribbons as a Function of Strain,Pore Morphology and Temperature

In this paper, the thermoelectric performance of porous armchair graphene nanoribbons under tensile and compressive strain is investigated as a function of pore morphology and temperature. For all the porous structures irrespective of their pore size, the performance improves at a compressive strain of 10%, while for tensile nature, the minimum cut-off strain required for improved thermoelectric figure of merit (ZT) shows an inverse relation with the pore size. In addition, optimal pore shape geometry can yield better performance, even at lower values of strain. Further analysis reveals that tensile strain is not able to improve the performance at low and intermediate temperatures of around 300 K, whereas tensile/compressive strain is effective in enhancing the performance of porous armchair graphene nanoribbons at higher temperatures. Furthermore, the structures are found to be more sensitive to compressive strain than the tensile one since the effect of compressive strain is found to improve ZT more significantly. Our analysis based on Non-Equilibrium Green’s function calculations suggests a possible route for tailoring the functionality of nanomaterials so as to achieve great potentials for thermoelectric applications at various temperatures.     

Experimental Investigation and Simulation of Magnetic Flux Leakage from Metal Loss Defects

Journal of Failure Analysis and Prevention - Magnetic flux leakage (MFL) principle is widely used in detecting defects in cross-country pipelines. The tools based on the MFL techniques termed as...     

Optical Kerr switching technique for the production of a picosecond,multiwavelength CO2 laser pulse

A wavelength-independent method for optical gating, based on the optical Kerr effect, has been demonstrated. Using this method, we produced 100-ps, 10-kW, two-wavelength pulses (10.3 and 10.6 microm) with a signal-to-background ratio contrast of 10(5) by slicing a long CO2 pulse. The capability of gating consecutive pulses separated on a picosecond time scale with this method is also shown.     

Practical calculation of switching surges at motor terminals

Switching of motors results in steep-fronted surges which cause a relatively large turn-to-turn stress in windings. Simplified and detailed methods are presented for calculating the surge level and risetime at the motor terminals for particular configurations. The levels are shown to be strongly affected by shield or conduit grounding practices and are less dependent on motor size or the number of other loads supplied by the metal-clad bus. The risetimes depend mainly on the motor cable impedance, the shield grounding practices, and an equivalent motor capacitance. Less sensitive parameters include metal-clad bus length, the breaker position, and cable losses associated with the dielectric, skin effect, and semiconductive layers. Comparisons are made with surges monitored during normal switching     

Molecularly Targeted Agents as Radiosensitizers in Cancer Therapy—Focus on Prostate Cancer

As our understanding of the molecular pathways driving tumorigenesis improves and more druggable targets are identified, we have witnessed a concomitant increase in the development and production of novel molecularly targeted agents. Radiotherapy is commonly used in the treatment of various malignancies with a prominent role in the care of prostate cancer patients, and efforts to improve the therapeutic ratio of radiation by technologic and pharmacologic means have led to important advances in cancer care. One promising approach is to combine molecularly targeted systemic agents with radiotherapy to improve tumor response rates and likelihood of durable control. This review first explores the limitations of preclinical studies as well as barriers to successful implementation of clinical trials with radiosensitizers. Special considerations related to and recommendations for the design of preclinical studies and clinical trials involving molecularly targeted agents combined with radiotherapy are provided. We then apply these concepts by reviewing a representative set of targeted therapies that show promise as radiosensitizers in the treatment of prostate cancer.