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1.
从电力与精确数字、模拟信号,到高压气态和液态介质,如今的用户定制电缆几乎无所不传。线缆制造商们现在可以提供的连接线缆材料可谓五花八门,从多种规格的传统铜线和光纤,到各类软管和导管,甚至包括碳纤维等半导体材料。在对一种专用电缆的设计作出最终决定前,要做一点“外形匹配”的工作。通常要回答的问题包括:“要传输些什么?”、“有什么限制条件?”、“完成任务应该采用何种连接物”。在进行优化的阶段,还要另外考虑使用环境,包括可能存在的电磁干扰、机械应力影响(如扭曲和/或摩擦)、化学和/或高温的损伤。细绞合铜导线在进行大功率…  相似文献   
2.
Research suggests that schizotypal personality disorder (SPD) is a part of the spectrum of schizophrenia-related illnesses. This article hypothesizes that a deficit in the representation and maintenance of context is a core cognitive disturbance in schizophrenia and that SPD individuals should demonstrate context-processing deficits. To test this hypothesis, the authors administered 3 versions of their AX-CPT task, designed to assess context processing, to 35 healthy controls and 26 individuals with DSM-IV SPD. They also administered working memory and selective attention tasks. SPD individuals displayed context representation deficits similar to those found in schizophrenia but did not show the same additional deficits in context maintenance. Context processing was strongly associated with working memory and selective attention performance in the SPD individuals. (PsycINFO Database Record (c) 2010 APA, all rights reserved)  相似文献   
3.
PURPOSE: We designed a phase I-II trial of three active agents, paclitaxel, ifosfamide, and vinorelbine, in advanced non-small-cell lung cancer (NSCLC) to: 1) define the dose-limiting toxicities (DLT) and maximum tolerated dose (MTD) of paclitaxel with filgrastim (G-CSF) support; and 2) determine the overall response rate and median survival of patients treated on this regimen. PATIENTS AND METHODS: We treated cohorts of patients with stage IIIB or IV NSCLC with ifosfamide 1.2-1.6 g/m2/day x 3 and vinorelbine 20-25 mg/m2/day x 3 and escalating doses of paclitaxel at 100-175 mg/m2 on day 2 with G-CSF support on a 21-day cycle. One prior experimental single-agent chemotherapy regimen was allowed. RESULTS: Fifty-six patients, were enrolled on this trial: 27 on the phase I portion of the study and an additional 29 at the recommended phase II dose (RPTD). Thirteen patients had received prior chemotherapy. Paclitaxel doses of 175 mg/m2 and 150 mg/m2 produced dose-limiting myelosuppression, and the RPTD was determined to be paclitaxel 135 mg/m2 with ifosfamide 1.2 g/m2/day on days 1-3 and vinorelbine 20 mg/m2/ day on days 1-3 with G-CSF support. The overall response rate was 18%, with a median survival of 6.1 months. Six of 35 patients (17%) treated at the RPTD achieved a partial response to therapy. Grade IV neutropenia was observed in 19 of 35 patients at this dose, with eight patients suffering febrile neutropenia. CONCLUSIONS: This non-cisplatin-containing three-drug regimen has substantial toxicity and low activity in advanced NSCLC, and does not seem to improve on prior regimens. It is unclear whether the lack of efficacy relates to an antagonistic reaction between the specific drugs, administration schedule, or to subtherapeutic doses of the individual agents.  相似文献   
4.
The tet(M) genes were characterized from 84 isolates of 10 different bacterial species isolated from the periodontal pockets of 16 patients with periodontal disease. A 740 bp polymerase chain reaction product from the hypervariable region of the tet(M) structural gene was cleaved with the restriction enzymes AluI and HinfI. Three different restriction patterns were identified for each of the two enzymes. By DNA sequencing, using a direct solid-phase automated sequencing method, the isolates could be grouped into 3 different clusters of tet(M) subtypes. The internal DNA homology within each subtype was 98-100%; the homology between clusters was 89-94%. Two different subtypes were identified in 9 of 10 bacterial species, and the remaining species had 3 different subtypes. One of the subtypes (M3) was seen mainly in the anaerobic isolates. This subtype was different from all earlier sequenced structural tet(M) genes present in the Genbank. Most patients had two different subtypes of tet(M), and a third subtype was seen in the 3 patients who exhibited the greatest variety of tetracycline-resistant bacterial species. It appears that the presence of one subtype of the tet(M) gene within a patient or bacterial species does not prevent the acquisition of another subtype of the same gene. This study identified a new subtype of the tet(M) gene and grouped it into 3 distinct yet highly homologous genetic subtypes.  相似文献   
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6.
A quantum chemical study of the binding of Li+ cation to polyalkyloxides has been carried out. The lithium cation interaction with three polyalkyloxides (polyethylene oxide (PEO), polytrimethylene oxide (PTMO), and polypropylene oxide (PPO)) has been investigated using ab initio molecular orbital theory at the HF/6-31G* level with molecular models for the polymers. Coordination by one to six oxygens was considered. In addition, higher level calculations were carried out using G3(MP2) theory for coordination of Li+ by one oxygen. For coordination of lithium by one oxygen, the binding energy ordering is PTMO>PPO>PEO, with PTMO having the largest lithium cation affinity. The same ordering is found for larger coordination numbers with the exception of coordination by six oxygens, where the ordering changes due to the steric interactions.  相似文献   
7.
ABSTRACT: In 1983 Chicago elected its first black mayor, Harold Washington. During Washington's first term of office, his administration not only reordered municipal priorities in such a fashion as to benefit his core, minority voting constituency, but also defined a municipal agenda emphasizing greater attention to neighborhood needs and more open government. In 1984 an important neighborhood coalition, the Save Our Neighborhoods/Save Our City Coalition (SON/SOC), proposed a linked development policy to tap downtown investment for neighborhood projects. Although SON/SOC's proposal was compatible with the Washington neighborhood agenda, this mainly white organization and the Washington administration experienced considerable difficulty in forging a mutually acceptable proposal The linked development debate in Chicago demonstrates the salience of race, class-cultural factors, and alternative approaches to neighborhood mobilization as barriers to the development of progressive coalitions in city politics.  相似文献   
8.
The increasing complecity of many expert system application areas calls for the integration of the knowledge of multiple experts. The use of multiple experts introduces some interesting new problems during the process of knowledge acquisition. The problems are further complicated when the experts are geographically dispersed or unavailable for face-to-face interactions.

This article discusses the motivations for acquiring the knowledge of multiple experts, the problems related to knowledge acquisition, new issues that arise whens multiple experts interact, solutions that can be brought to bear in building multiple expert systems (particularly when experts are geographically dispersed), and new tools for knowledge engineers to use when dealing with multiple experts.  相似文献   

9.
Multimedia data from two probability-based exposure studies were investigated in terms of how missing data and measurement-error imprecision affected estimation of population parameters and associations. Missing data resulted mainly from individuals'refusing to participate in certain measurement activities, rather than from field or laboratory problems; it suggests that future studies should focus on methods for maximizing participation rates. Measurement error variances computed from duplicate-sample data were small relative to the inherent variation in the populations; consequently, adjustments in nonparametric percentile estimates to account for measurement imprecision were small. Methods of adjustment based on lognormality assumptions, however, appeared to perform poorly.  相似文献   
10.
Fingerprints are the oldest and most widely used biometrics for personal identification. Unfortunately, it is usually possible to deceive automatic fingerprint identification systems by presenting a well-duplicated synthetic or dismembered finger. This paper introduces one method to provide fingerprint vitality authentication in order to solve this problem. Detection of a perspiration pattern over the fingertip skin identifies the vitality of a fingerprint. Mapping the two-dimensional fingerprint images into one-dimensional signals, two ensembles of measures, namely static and dynamic measures, are derived for classification. Static patterns as well as temporal changes in dielectric mosaic structure of the skin, caused by perspiration, demonstrate themselves in these signals. Using these measures, this algorithm quantifies the sweating pattern and makes a final decision about vitality of the fingerprint by a neural network trained by examples.  相似文献   
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