Performance engineering and topological design of metro WDM opticalnetworks using computer simulation

This paper demonstrates the use of computer simulation for topological design and performance engineering of transparent wavelength-division multiplexing metropolitan-area networks. Engineering of these networks involves the study of various transport-layer impairments such as amplifier noise, component ripple, chirp/dispersion, optical crosstalk, waveform distortion due to filter concatenation, fiber nonlinearities, and polarization effects. A computer simulation methodology composed of three main simulation steps is derived and implemented. This methodology obtains performance estimations by applying efficient wavelength-domain simulations on the entire network topology, followed by time-/frequency-domain simulations on selected paths of the network and finally Q-budgeting on an identified worst case path. The above technique provides an efficient tool for topological design and network performance engineering. Accurate simulation models are presented for each of the performance impairments, and the computer simulation methodology is used for the design and engineering of a number of actual metro network architectures     

Improving the performance of passive network monitoring applications with memory locality enhancements

Passive network monitoring is the basis for a multitude of systems that support the robust, efficient, and secure operation of modern computer networks. Emerging network monitoring applications are more demanding in terms of memory and CPU resources due to the increasingly complex analysis operations that are performed on the inspected traffic. At the same time, as the traffic throughput in modern network links increases, the CPU time that can be devoted for processing each network packet decreases. This leads to a growing demand for more efficient passive network monitoring systems in which runtime performance becomes a critical issue.In this paper we present locality buffering, a novel approach for improving the runtime performance of a large class of CPU and memory intensive passive monitoring applications, such as intrusion detection systems, traffic characterization applications, and NetFlow export probes. Using locality buffering, captured packets are being reordered by clustering packets with the same port number before they are delivered to the monitoring application. This results in improved code and data locality, and consequently, in an overall increase in the packet processing throughput and decrease in the packet loss rate. We have implemented locality buffering within the widely used libpcap packet capturing library, which allows existing monitoring applications to transparently benefit from the reordered packet stream without modifications. Our experimental evaluation shows that locality buffering improves significantly the performance of popular applications, such as the Snort IDS, which exhibits a 21% increase in the packet processing throughput and is able to handle 67% higher traffic rates without dropping any packets.     

Conversion of a benign lymphoepithelial salivary gland lesion to lymphocytic lymphoma during dilantin therapy: correlation with dilantin-induced lymphocyte transformation in vitro

A patient with a classical salivary gland benign lymphoepithelial lesion (BLL) that converted to a lymphoblastic lymphoma (LSA) localized to the salivary glands is described. The malignant transformation of the BLL was preceded by Dilantin anticonvulsant therapy, and in vitro tests subsequent to the development of LSA demonstrated positive Dilantin-induced lymphocyte transformation. The lymphoma was treated successfully by local irradiation, chemotherapy, and discontinuation of Dilantin. The case illustrates the "prelymphomatous" nature of BLL in certain patients, as well as the possible potential danger of Dilantin and other lymphoid-stimulating drugs in discussed. Further study of drugs capable lymphocyte transformation in patients with prelymphomatous disorders is warranted.     

Antenna applications of negative-refractive-index transmission-line structures

A number of new antenna-related applications that have recently been developed at the University of Toronto based on the concept of negative-refractive-index transmission-line metamaterials are reviewed. These include non-radiating phase-shifting lines that can produce either a positive or a negative phase-shift while exhibiting a broadband linear phase response, as well as compact and broadband series power dividers and associated planar series-fed printed dipole arrays with reduced beam-squinting. Moreover, a fully printed electrically small ring antenna featuring vertical polarisation and good radiation efficiency is also described     

Effects of filter concatenation for directly modulated transmissionlasers at 2.5 and 10 Gb/s

We report computer simulation results of the effects on optical signal quality of passage through a cascade of wavelength division multiplexing (WDM) filters-multiplexers and demultiplexers-for directly modulated lasers with different chirp characteristics. In particular, lasers with transient or adiabatic chirp characteristics at 2.5 Gb/s and 10 Gb/s are investigated, and we find clear differences between the laser types with respect to filter concatenation effects. Filters with an optical bandwidth suitable for a 200-GHz channel-spacing system are considered, and we evaluate the system behavior as a function of laser frequency offset for a fixed number of filters. The reference network architecture used for the simulations is an optically transparent metropolitan scale network in which the WDM signals may be demultiplexed and then multiplexed again at multiple optical network elements. The signal quality is evaluated in terms of a distortion-induced eye-closure penalty as well as the excess attenuation or loss suffered. We find that transient chirp-dominated lasers show a generally symmetric distortion penalty response to laser frequency offset, whereas the response for adiabatic chirp dominated lasers is highly asymmetric. Furthermore, the extinction ratio for the latter class of lasers can be improved, in some cases, by the appropriate offset between laser and filter center frequencies     

Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo

There has been considerable interest in the potential role of growth factors in the initiation and development of cutaneous malignant melanoma (CMM). Platelet-derived growth factor (PDGF) has been shown to be secreted by melanoma cell lines and by metastatic melanoma in vivo. PDGF also has been reported to stimulate the development of tumour stroma and new blood vessels. We studied the expression of PDGF and its receptors by both immunohistochemistry (IHC) and in situ hybridization (ISH) in primary and metastatic melanoma and in normal skin specimens. Cryostat sections were incubated with 35S-labelled riboprobes and antibodies for PDGF-AA, PDGF-alpha receptor, PDGF-BB and PDGF-beta receptor. Both primary and metastatic melanoma exhibited significant expression of PDGF-AA, PDGF-BB and PDGF-alpha receptor by both IHC and ISH, compared with only background expression in normal skin. We did not observe expression of PDGF-beta receptor in melanoma. Our results suggest that PDGF may function as an autocrine growth factor, as well as an angiogenesis factor, in CMM tumour development. This expression of the PDGF-alpha receptor rather than the beta receptor may be unique among solid tumours.     

Crystallization of amorphous silicon thin films: comparison between experimental and computer simulation results

Polycrystalline silicon obtained by the crystallization of thin amorphous silicon films has been an important material for microelectronics technology during the last decades. Many properties are improved in crystallized amorphous silicon compared to the as-deposited polysilicon such as larger grain size, smoother surface, and higher-carrier mobility. In this work, the crystallization of amorphous silicon is investigated by combining transmission electron microscopy (TEM) observations and molecular dynamics calculations. TEM observations on a series of specimens have shown that the majority of the silicon grains are oriented with a zone axis normal to the surface. In order to understand the crystallization mechanism molecular dynamic simulations were performed. It is found that the c/amorphous interface exhibits the lowest reduced interfacial energy density while the c/amorphous has the lowest reduced energy differences per unit interfacial area. The most energetically unfavorable interface is c/amorphous.     

Performance Outages in CWDM Optical Networks due to the Polarization-Dependent Gain of Semiconductor Optical Amplifiers

This letter presents, for the first time, the derivation of analytical formulae for the probability density function and the cumulative density function (cdf) of the optical signal-to-noise ratio variation in optical local and metropolitan area networks employing coarse wavelength-division multiplexing due to the weak polarization-dependent gain (PDG) of cascaded semiconductor optical amplifiers (SOAs). The cdf is used to calculate the outage probability and to derive specifications for the maximum allowable value of PDG per SOA in order to achieve a given network size     

Equilibrium in multiphase polydisperse fuids

Based on the principle of Gibbs phase equilibrium, three different algorithms are developed for phase equilibrium calculations of polydisperse mixtures. These algorithms are based on (i) the equality of the chemical potentials of components in each phase, (ii) the minimization of the total Gibbs free energy of the system with respect to all the system variables, and (iii) the equilibrium ratios constraint between the phases. All three algorithms demonstrate applicability to mixtures with different mole fraction distribution functions and different equations of state. The results of calculations using the three phase algorithms are compared with the simulated multicomponent hydrocarbon mixture data, and the results are in good agreement.Nomenclature a, b Interaction parameter in the equation of state - CP Critical point - F(I) Density distribution function - f Fugacity - G Gibbs free energy - I Distributed variable - I ₀ Initial value of density distribution function - K(I) Equilibrium ratio of component I - P Pressure (atm) - R Gas constant - T Temperature (K) - v Molar volume - Z Compressibility factor - h Variance of density distribution function - Chemical potential - F _v Moles vapor per moles in system - Y Fugacity coefficient - i, j Component identifiers - f Feed stream - L Liquid phase - V Vapor phase