Synthesis and Reactions of Some New Pyrrolylfuro[2,3‐d]Pyrimidines and Pyrrolopyrazinofuropyrimidines

5‐Amino‐4‐methyl‐2‐phenyl‐6‐substitutedfuro[2,3‐d]pyrimidines ( 2a‐c ) were reacted with 2,5‐dimethoxytetrahydrfuran to afford the pyrrolyl derivatives 3a‐c . Compound 3a was chosen as intermediate for the synthesis of poly fused heterocycles incorporated furopyrimidines moiety 4–11 . Some of the synthesized compounds were screened for their antibacterial and antifungal activities.     

The focusing problem for the Eikonal equation

We study the focusing problem for the eikonal equation¶¶ ?_tu=| ?u| ², \partial _{t}u=\left| \nabla u\right| ^{2}, ¶¶i.e., the initial value problem in which the support of the initial datum is outside some compact set in R^d \mathbf{R}^{d} . The hole in the support will be filled in finite time and we are interested in the asymptotics of the hole as it closes. We show that in the radially symmetric case there are self-similar asymptotics, while in the absence of radial symmetry essentially any convex final shape is possible. However in R² \mathbf{R}^2 , for generic initial data the asymptotic shape will be either a vanishing triangle or the region between two parabolas moving in opposite directions (a closing eye). We compare these results with the known results for the porous medium pressure equation which approaches the eikonal equation in the limit as m? 1 m\rightarrow 1 .