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Hayrullah Manyas Berna Eroğlu Filibeli İlkay Ayrancı Merve S. Güvenç Bumin N. Dündar Gönül Çatlı 《Andrologia》2021,53(6):e14017
17β-hydroxysteroid dehydrogenase type 3 deficiency is a rare cause of 46 XY disorders of sexual development. Mutations in the HSD17B3 gene result in reduced activity of the 17β-HSD3 enzyme, decreasing the conversion of androstenedione to testosterone. In this report, two cases, admitted with different clinical findings in the neonatal and adolescent periods and were decided to be raised in different genders are presented. The first case who had complete female external genitalia presented on the third postnatal day with the complaint of swelling in the groin. He was decided to be raised as a male and was treated successfully with parenteral testosterone in order to increase phallus size before surgical correction of the external genitalia. The second case was an adolescent girl who presented due to pubertal virilisation and primary amenorrhoea and chose female gender. Molecular genetic analyses of the HSD17B3 gene revealed two different previously reported homozygous variants. We emphasise that patients with 17β-hydroxysteroid dehydrogenase type 3 deficiency can present with heterogeneous clinical findings in different age groups. Early diagnosis is important to prevent future gender confusion and related problems. 相似文献
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Derici H Bozdağ AD Tansug T Nazli O Reyhan E 《Surgical laparoscopy, endoscopy & percutaneous techniques》2007,17(6):521-523
Perforation of the gall bladder is a frequent complication during laparoscopic cholecystectomy. Grasping the perforated part of the gall bladder, clip application, or endoscopic loop application are possible solutions to prevent spillage. We propose laparoscopic rubber band application to close the perforated part of the gall bladder as an easy and safe method. We performed rubber band application after iatrogenic perforation of the gall bladder during laparoscopic cholecystectomy in 5 patients. Two-millimeter-wide multiple rubber rings, cut from a 14-Fr Foley catheter, are loaded on a grasper. When a perforation occurred during the dissection of the gall bladder, the hole is grasped with this instrument and 1 of the rings is placed on the gall bladder by the aid of a dissector. Thus, the grasper remained available for traction of the Hartmann's pouch during further dissection of the gall bladder. The rubber bands were placed successfully in all cases. Two perforations occurred in 1 case, and 2 bands were placed with ease. Bile leakage or gall stone spillage did not occur. Operation time was not prolonged. Rubber band ligation of perforation of the gall bladder is a simple, safe, inexpensive, and effective method to prevent spillage of the bile or gallstones in laparoscopic surgery. 相似文献
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Diagnosis and treatment of gallbladder perforation 总被引:2,自引:0,他引:2
Derici H Kara C Bozdag AD Nazli O Tansug T Akca E 《World journal of gastroenterology : WJG》2006,12(48):7832-7836
INTRODUCTION Gallbladder perforation (GBP) is a rare but life threatening complication of acute cholecystitis. Sometimes GBP may not be different from uncomplicated acute cholecystitis with high morbidity and mortality rates because of delay in diagnosis[… 相似文献
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Ali Dogan Bozdag Ismail Yaman Hayrullah Derici Tugrul Tansug Vedat Deniz 《World journal of gastroenterology : WJG》2009,15(44):5573-5578
AIM: To compare the results of the anoscope of the PPH kit and a modified anoscope during stapled haemorrhoidopexy.METHODS: The hospital records of 37 patients who underwent stapled haemorrhoidopexy between 2001 and 2006 were reviewed. The purse-string suture anoscope in the PPH kit was used on 15 patients (Group 1),and the modified anoscope was used on 22 patients(Group 2). Demographic characteristics of the patients,operation time, surgeon's performance, analgesic requirement, and complications were compared.RESULTS: Operation time was significantly longer in Group 1 (42.0±8.4 min vs 27.7±8.0 min, P = 0.039).The surgeons reported their operative performance as significantly better in Group 2 (the results of the assessments were poor in ten, medium in four and good in one in Group 1, while good in all patients in Group 2, P < 0.001). The need for haemostatic sutures was significantly higher in Group 1 (six cases) and was needed in two cases in Group 2 ( P = 0.034).CONCLUSION: Operation time decreased and the surgeon's satisfaction increased with use of the modified anoscope, and fewer haemostatic sutures were required if the surgeon waited longer before and after firing the stapler. 相似文献
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Beray Selver Eklio?lu Mehmet Emre Atabek Nesibe Akyürek Hayrullah Alp 《Journal of clinical research in pediatric endocrinology》2015,7(3):222-227
Objective:The aim of this study was to evaluate the periaortic fat thickness (PAFT) using conventional echocardiography in obese children and adolescents with non-alcoholic fatty liver disease (NAFLD).Methods:Two hundred and ninety-seven obese children and adolescents were included in the study. Anthropometric measurements were made in all subjects, and fasting venous blood samples were taken for determination of glucose, insulin, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels. Ultrasonography of the liver was used for assessment of NAFLD and the subjects were grouped as NAFLD and non-NAFLD. Echocardiography was performed in all subjects.Results:PAFT was higher in patients with NAFLD compared with the non-NAFLD group. In patients with NAFLD, PAFT was positively correlated with waist circumference and with total cholesterol levels. In multiple regression analysis, waist circumference (β=0.28, p=<0.001) was found to be the best predictor of PAFT.Conclusion:Conventional echocardiography may be used to determine increased PAFT at an early stage in obese children and adolescents with NAFLD for careful monitoring of cardiovascular risk. 相似文献
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Objective
This study was conducted to examine the effect of education on quality of life and constipation severity in patients with primary constipation.Methods
This randomised controlled study was conducted with 80 patients who applied at the gastroenterology outpatient clinic of a university hospital. In the study, the Constipation Questionnaire, Constipation Quality-of-Life Questionnaire (PAC-QOL), and Constipation Severity Instrument (CSI) were used.Results
It was that found after 4 weeks of education, the total PAC-QOL mean score decreased to 60.85?±?5.65 and total CSI mean score decreased to 20.17?±?4.05 in the intervention group (p?<?0.001). No change was observed in the patients in the control group (p?>?0.05). After 4 weeks, a statistical difference was found between the two groups in PAC-QOL mean score and CSI mean score (p?<?0.05).Conclusion
It was determined that the education given to individuals with primary constipation decreased the constipation severity and increased the quality of life.Practice implications
Constipation education will make a contribution to the active use of follow-up forms by nurses in the clinic for the diagnosis of constipation, individual assessment of each patient, and their active role in constipation management. 相似文献10.
Hayrullah Derici Haluk R. Unalp Okay Nazli Erdinc Kamer Murat Coskun Tugrul Tansug Ali D. Bozdag 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2010,395(5):575-579