全文获取类型
收费全文 | 2175篇 |
免费 | 108篇 |
国内免费 | 94篇 |
学科分类
医药卫生 | 2377篇 |
出版年
2021年 | 16篇 |
2020年 | 18篇 |
2019年 | 24篇 |
2018年 | 24篇 |
2017年 | 31篇 |
2016年 | 27篇 |
2015年 | 47篇 |
2014年 | 63篇 |
2013年 | 89篇 |
2012年 | 73篇 |
2011年 | 79篇 |
2010年 | 77篇 |
2009年 | 55篇 |
2008年 | 67篇 |
2007年 | 110篇 |
2006年 | 70篇 |
2005年 | 73篇 |
2004年 | 56篇 |
2003年 | 67篇 |
2002年 | 69篇 |
2001年 | 42篇 |
2000年 | 31篇 |
1999年 | 45篇 |
1998年 | 48篇 |
1997年 | 66篇 |
1996年 | 44篇 |
1995年 | 49篇 |
1994年 | 41篇 |
1993年 | 36篇 |
1992年 | 31篇 |
1991年 | 22篇 |
1990年 | 33篇 |
1989年 | 46篇 |
1988年 | 34篇 |
1987年 | 32篇 |
1986年 | 22篇 |
1985年 | 29篇 |
1984年 | 19篇 |
1983年 | 16篇 |
1982年 | 15篇 |
1981年 | 15篇 |
1977年 | 14篇 |
1976年 | 19篇 |
1975年 | 12篇 |
1972年 | 13篇 |
1967年 | 13篇 |
1966年 | 15篇 |
1965年 | 19篇 |
1963年 | 15篇 |
1959年 | 15篇 |
排序方式: 共有2377条查询结果,搜索用时 15 毫秒
1.
2.
3.
Dr. Ewald Hering 《Virchows Archiv : an international journal of pathology》1863,26(5-6):560-572
Ohne ZusammenfassungSiehe dies. Archiv Bd. XXV. S. 1. 相似文献
4.
5.
6.
Gopala K RANGAN Yiping WANG Yuet-Ching TAY Liguang CHEN David CH HARRIS 《Nephrology (Carlton, Vic.)》1998,4(1-2):57-64
SUMMARY: The effect of mild acute tubular injury on the progression of tubulointerstitial fibrosis was studied in pair-fed uninephrectomized male Wistar rats with established adriamycin nephrosis ( n = 34). Rats were stratified into three groups according to endogenous creatinine clearance (CrCl), proteinuria (Upr) and body weight (BW): (i) group 1 (Fe, n = 12) received a single intraperitoneal injection of ferric nitrilotriacetate (5 mg Fe/kg BW); (ii) group 2 (G, n = 10) three daily subcutaneous injections of gentamicin (60 mg/kg BW) and; (iii) group 3 (C, n = 12) saline injections. Serial CrCl (day 2, day 5, weeks 2, 4, 6 and 8) and renal histology (week 8) were examined following administration of nephrotoxin. CrCl was reduced on d2 (Fe: 0.78 ± 0.23 mL/min; mean ± SD) and day 5 (G: 0.91 ± 0.36 mL/min) as compared with C (1.22 ± 0.12 mL/min; P <0.05). There was no change in the serum creatinine and functional recovery occurred by d5 (Fe) and week 2 (G). Upr decreased transiently in G at week 2 (G: 482 ± 208 mg/day vs C: 716 ± 233; P = 0.05) despite similar food intake, baseline Upr and CrCl. At week 8, CrCl in Fe (0.84 ± 0.40 mL/min) was similar to C (0.84 ± 0.58 mL/min), whereas in G it remained stable (1.27 ± 0.39 mL/min; P <0.05). By morphometric analysis, mean relative interstitial volume (RIV) and glomerulosclerosis (GS) in Fe (RIV: 28.5 ± 13.4%; GS: 10.3 ± 12.3%) was no different to C (RIV: 24.5 ± 12.5%; GS: 20.9 ± 20.0%), whereas both parameters were reduced in G (RIV: 14.1 ± 8.1%; GS: 4.0 ± 4.8%; P <0.05). Mild gentamicin nephrotoxicity therefore reduced the progression of adriamycin nephrosis. the mechanism of this finding is unclear, but it may relate to altered glomerular and tubular cell handling of protein. 相似文献
7.
Macrophages and translymphatic absorption represent the first line of host defense of the peritoneal cavity 总被引:5,自引:0,他引:5
D L Dunn R A Barke D C Ewald R L Simmons 《Archives of surgery (Chicago, Ill. : 1960)》1987,122(1):105-110
To quantitate the host defenses of the rat peritoneal cavity, nonviable radiolabeled Escherichia coli were injected intraperitoneally and clearance, leukocyte influx, and phagocytosis were examined. Macrophages (MCs) were present initially and remained relatively constant in number. The polymorphonuclear leukocyte (PMN) response began at one to two hours and was maximal at 24 to 72 hours. A previously unidentified inoculum-dependent PMN response was defined. Clearance and phagocytosis were extremely rapid, and few (less than 3%) free bacteria were present after two hours. Phagocytic activity of MCs and PMNs was identical, but MCs were numerically predominant initially and thus accounted for the majority of early phagocytosis. Thus, MC phagocytosis and clearance represent the primary line of host peritoneal defenses. We hypothesize that the subsequent inoculum-dependent PMN response may have evolved to cope with those larger inocula for which this initial response is inadequate. 相似文献
8.
9.
无环鸟苷亲脂性前体药物脂质体的制备及体外抗病毒活性(英文) 总被引:2,自引:0,他引:2
本文通过将无环鸟苷(acyclovir,简称ACV)2’位羟基分别与月桂酰氯或棕榈酰氯进行酯化反应,制得亲脂性前体药物无环鸟苷月桂酸酯和无环鸟苷棕榈酸酯(分别简称为C12-ACV和C16-ACV),使脂质体包封率从ACV的29.9%提高到C12-ACV的95.6%和C16-ACV的97.1%;漏泄实验表明在4℃透析60h后,一半以上的ACV从脂质体中漏泄,而C12-ACV和C16-ACV的滞留率分别为70%和80%;体外抗疱疹病毒的试验中,在最低试验浓度0.044μmol/L时,ACV不显示抗病毒活性,而C16-ACV脂质体抑制细胞病变率达75%,说明前体药物通过与脂质体脂膜的结合增加了药物的进入细胞能力,从而提高了ACV的抗病毒能力。 相似文献
10.
Kundel HL; Gefter W; Aronchick J; Miller W Jr; Hatabu H; Whitfill CH; Miller W Sr 《Radiology》1997,205(3):859