Confined batch foaming of semi-crystalline rubbery elastomers with carbon dioxide using a mold

Confined foaming of poly(ethylene-co-vinyl acetate-co-carbon monoxide) using carbon dioxide as a physical blowing agent in a mold with either permeable or impermeable boundaries has been explored as a strategy to control final foam dimensions and morphology. The results are discussed in terms of comparisons to free-foaming experiments conducted at the same pressure and temperature conditions following the same pressurization and depressurization paths. Foaming experiments were carried out at 30 and 40°C and 100, 200, and 300 bar followed by rapid depressurization of the foaming cell. Confined foaming led to smaller pores with more uniform distributions across the polymer cross-section. However, bulk foam densities of the foams generated under confinement were higher than those generated under the free-foaming mode. Surface characteristics and skin layer formation were altered by expansion against both the permeable and impermeable boundaries. Confined foaming promotes uniform pore distribution and overall dimensional uniformity and may impart surface texture but the trade-off is in the degree to which the bulk foam density can be lowered.     

Halting the hallmarks: a cellular automaton model of early cancer growth inhibition

Cancer treatment is a fragmented and varied process, as “cancer” is really hundreds of different diseases. The “hallmarks of cancer” proposed by Hanahan and Weinberg (Cell 100(1):57–70, 2000) are a framework for viewing cancer within a common set of underlying principles—ten properties that are common to almost all cancers, allowing them to grow uncontrollably and ravage the body. We used a cellular automaton model of tumour growth paired with lattice Boltzmann methods modelling oxygen flow to simulate combination drugs targeted at knocking out pairs of hallmarks. We found that knocking out some pairs of cancer-enabling hallmarks did not prevent tumour formation, while other pairs significantly prevent tumour growth (\(p=0.0004\) using Wilcoxon signed-rank adjusted with the Bonferroni correction for multiple comparisons). This is not what would be expected from models of knocking out the hallmarks individually, as many pairs did not have an additive effect but had either no statistically significant effect or a multiplicative one. We propose that targeting certain pairs of cancer hallmarks, specifically cancers ability to induce blood vessel development paired with another cancer hallmark, could prove an effective cancer treatment option.     

Spiral-shaped inertial stem cell device for high-throughput enrichment of iPSC-derived neural stem cells

Stem cell enrichment plays a critical role in both research and clinical applications. The typical method for stem cell enrichment may use invasive processes and takes a long period of time. Spiral-shaped microfluidic devices, which combine lift and Dean drag forces to direct cells of different sizes into separate trajectories, can be used to noninvasively process samples at a rate of milliliters per minute. This paper presents a simple 2-loop spiral-shaped inertial microfluidic devices with the aid of sheath flow to enrich neural stem cells (NSCs), derived from induced pluripotent stem cells. NSCs and spontaneously differentiated non-neural cells were mixed and flowed through the spiral-shaped devices. Samples collected at the outlets were analyzed for purity and recovery. It was found that the device focused the NSCs into a narrow trajectory, which could then be collected in two out of the eight outlets. The device was tested at different flow rates and found that the most highly enriched fractions (2.1×) with NSCs recovery 93% were achieved at the flow rate (3 ml/min). Next, we extended our investigation from 2-loop design to 10-loop design to eliminate the use of sheath flow. NSCs were enriched to 2.5×, but only 38% of the NSCs were recovered from the most enriched fractions. Spiral-shaped microfluidic devices are capable of rapid, label-free enrichment of target stem cells, and have great potential in point-of-care tissue preparation.     

The effectiveness of Light Rail transit in achieving regional CO<Subscript>2</Subscript> emissions targets is linked to building energy use: insights from system dynamics modeling

Cities worldwide face the challenges of accommodating a growing population, while reducing emissions to meet climate mitigation targets. Public transit investments are often proposed as a way to curb emissions while maintaining healthy urban economies. However, cities face a system-level challenge in that transportation systems have cascading effects on land use and economic development. Understanding how an improved public transit system could affect urban growth and emissions requires a system-level view of a city, to anticipate side effects that could run counter to policy goals. To address this knowledge gap, we conducted a case study on the rapidly growing Research Triangle, North Carolina (USA) region, which has proposed to build a Light Railway by 2026 along a heavily used transportation corridor between the cities of Durham and Chapel Hill. At the same time, Durham County has set a goal of lowering greenhouse gas emissions by 30% from a 2005 baseline by 2030. In collaboration with local stakeholders, we developed a system dynamics model to simulate how Light Rail transit and concurrent policies could help or hinder these sustainable growth goals. The Durham–Orange Light Rail Project (D–O LRP) model simulates urban–regional dynamics between 2000 and 2040, including feedbacks from energy spending on economic growth and from land scarcity on development. Counter to expectations, model scenarios that included Light Rail had as much as 5% higher regional energy use and CO₂ emissions than business-as-usual (BAU) by 2040 despite many residents choosing to use public transit instead of private vehicles. This was largely due to an assumption that Light Rail increases demand for commercial development in the station areas, creating new jobs and attracting new residents. If regional solar capacity grew to 640 MW, this would offset the emissions growth, mostly from new buildings, that is indirectly due to Light Rail. National trends in building and automobile energy efficiency, as well as federal emissions regulation under the Clean Power Plan, would also allow significant progress toward the 2030 Durham emissions reduction goal. By simulating the magnitude of technology and policy effects, the D–O LRP model can enable policy makers to make strategic choices about regional growth.     

"Factor structure of the BASC-2 Behavioral and Emotional Screening System Student Form": Correction to Dowdy et al. (2011).

Reports an error in "Factor structure of the BASC–2 Behavioral and Emotional Screening System Student Form" by E. Dowdy, et al. (Psychological Assessment. np). There was an omission in the author note. The author note should have included a disclosure as follows, “Randy W. Kamphaus wishes to disclose a potential conflict of interest in that he receives a portion of royalties on net sales of BESS.” (The following abstract of the original article appeared in record 2011-04578-001.) The BASC–2 Behavioral and Emotional Screening System (BESS) Student Form (Kamphaus & Reynolds, 2007) is a recently developed youth self-report rating scale designed to identify students at risk for behavioral and emotional problems. The BESS Student Form was derived from the Behavior Assessment System for Children—Second Edition Self-Report of Personality (BASC–2 SRP; Reynolds & Kamphaus, 2004) using principal component analytic procedures and theoretical considerations. Using 3 samples, the authors conducted exploratory factor analyses (EFA) and confirmatory factor analyses (CFA) to understand the underlying factor structure of the BESS Student Form. The results of the EFA suggested that the SRP contained a 4-factor (i.e., Personal Adjustment, Inattention/Hyperactivity, Internalizing, School Problems) emergent structure, which was supported by CFA in 2 additional samples. Practical and research implications are discussed. (PsycINFO Database Record (c) 2011 APA, all rights reserved)     

Improvements in partner support predict sexual satisfaction among individuals with multiple sclerosis.

Purpose: Sexual dysfunction and low sexual satisfaction are common among individuals with multiple sclerosis (MS); however, little is known about factors that influence sexual satisfaction within this population. As such, the purpose of this study was to investigate the extent to which changes in negative and positive partner support predict sexual satisfaction levels over time in individuals with MS. Design: Eighty-one individuals with MS completed measures of sexual dysfunction, sexual satisfaction, partner social support, and depression. Data from baseline and posttreatment follow-up were obtained from a larger randomized clinical trial of telephone-administered psychotherapy for depression in a population with MS. Multiple regression analyses were conducted with change in overall sexual satisfaction from baseline to posttreatment as the outcome variable. Results: After controlling for age, gender, sexual dysfunction, years diagnosed with MS, and depression severity, those with increased positive partner support reported significant improvement in sexual satisfaction over time (β = .50, p     

Testing the Interactivity Principle: Effects of Mediation, Propinquity, and Verbal and Nonverbal Modalities in Interpersonal Interaction

Early channel reliance research compared different modes of communication to assess relationships among nonverbal and verbal cues. Emerging communication technologies represent a new venue for gaining insights into the same relationships. In this article, the authors advance a principle of interactivity as a framework for decomposing some of those relationships and report an experiment in which physical proximity—whether actors are in the same place ("co-located") or interacting at a distance ("distributed")—and the availability of other nonverbal environmental, auditory, and visual information in distributed modes is varied. Results indicate that both proximity and availability of nonverbal cues affect communication processes, social judgments participants make about each other, and task performance. The authors discuss implications about gains and losses due to presence of nonverbal features.     

Low-Temperature Synthesis of Zinc Oxide Nanoparticles

Crystalline zinc oxide nanoparticles have been prepared by mixing aqueous solutions of zinc nitrate and hexamethylenetetramine (HMT) at 60°C and 80°C. Transmission electron microscopy and X-ray diffraction show that the ZnO nanoparticles of diameters ranging from 15–33 nm and 25–43 nm long are formed. Aspect ratio is observed to range from 1.18 to 1.74 at 60°C and 1.22 to 1.70 at 80°C as the HMT to zinc nitrate concentration ratio increases from 10 to 150. Nanoparticle size decreases as the concentration of HMT increases. Much larger ZnO particles are formed with ammonium hydroxide as a hydrolysis agent without HMT. In summary, HMT is an ammonium-hydroxide source in the reaction, a surfactant for retaining nanosize, and not necessarily a template for ZnO nucleation.     

Consumer assessment of safety and date labeling statements on ready-to-eat meat and poultry products designed to minimize risk of listeriosis

Point-of-purchase safety-based labeling guidance on the proper storage and handling of refrigerated ready-to-eat (RTE) meat and poultry products could help reduce the risk of listeriosis. Seniors and pregnant women are two population groups at increased risk of listeriosis due to suppressed or compromised immune systems. We conducted 11 focus groups with senior-aged women and women of childbearing age in Colorado and Ohio to assess consumer awareness of Listeria, storage practices of RTE meat products, perceptions regarding the acceptability and usefulness of common date and potential food safety labeling statements on RTE meat and poultry products, and food safety information needs. Storage times for opened and unopened RTE products varied widely, with opened products often being stored longer than recommended. Women in both age groups paid attention to date labels on packages but varied highly in their interpretation of the statements. "Use by" statements were considered clearer and more helpful than "Sell by" or "Best if used by" labels. Proposed food safety-based labeling statements listing "antilisterial" agents used in RTE products were not well received. However, labels giving consumers instructions on how long they could keep RTE products and when to discard them after opening were considered helpful and well received. Participants indicated the need for further information about Listeria and its control. Educational information at point-of-purchase and where seniors and pregnant women congregate are suggested. Manufacturers are encouraged to provide more complete information on the safe storage and use of ready-to-eat meat and poultry products on package labels.