全文获取类型
收费全文 | 13243篇 |
免费 | 995篇 |
国内免费 | 19篇 |
学科分类
医药卫生 | 14257篇 |
出版年
2023年 | 91篇 |
2021年 | 167篇 |
2020年 | 173篇 |
2019年 | 239篇 |
2018年 | 236篇 |
2017年 | 215篇 |
2016年 | 241篇 |
2015年 | 255篇 |
2014年 | 301篇 |
2013年 | 471篇 |
2012年 | 582篇 |
2011年 | 605篇 |
2010年 | 368篇 |
2009年 | 361篇 |
2008年 | 634篇 |
2007年 | 538篇 |
2006年 | 565篇 |
2005年 | 582篇 |
2004年 | 517篇 |
2003年 | 473篇 |
2002年 | 429篇 |
2001年 | 476篇 |
2000年 | 410篇 |
1999年 | 364篇 |
1998年 | 142篇 |
1997年 | 109篇 |
1996年 | 122篇 |
1995年 | 118篇 |
1994年 | 113篇 |
1993年 | 111篇 |
1992年 | 270篇 |
1991年 | 295篇 |
1990年 | 318篇 |
1989年 | 316篇 |
1988年 | 229篇 |
1987年 | 251篇 |
1986年 | 247篇 |
1985年 | 241篇 |
1984年 | 177篇 |
1983年 | 170篇 |
1982年 | 117篇 |
1980年 | 82篇 |
1979年 | 167篇 |
1978年 | 113篇 |
1977年 | 94篇 |
1975年 | 93篇 |
1974年 | 106篇 |
1973年 | 96篇 |
1972年 | 77篇 |
1971年 | 81篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
1.
2.
3.
4.
Anders Elm Pedersen Esben Gjerløff Wedebye Schmidt Jesper Freddie Sørensen Carsten Faber Boye Schnack Nielsen Kim Holmstrøm Silje Haukali Omland Peter Tougaard Søren Skov Bo Bang 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(7):547-555
TL1A is a TNF‐like cytokine which has been shown to co‐stimulate TH1 and TH17 responses during chronic inflammation. The expression of this novel cytokine has been investigated in inflammatory disorders like rheumatoid arthritis and inflammatory bowel disease, but little is known about expression and induction in psoriasis. Indeed, the pathogenesis in psoriasis is still not fully understood and it is speculated that cytokines other than TNF‐α are important in subsets of patients. Also, for patients with severe disease that are treated with systemic anti‐TNF‐α blockade, novel candidates to be used as disease and response biomarkers are of high interest. Here, we demonstrate TL1A expression in biopsies from psoriatic lesions. Also, we investigated spontaneous and induced TL1A secretion from PBMCs and blood levels from a cohort of psoriasis patients. Here, increased spontaneous secretion from PBMCs was observed as compared to healthy controls and a small subset of patients had highly elevated TL1A in the blood. Interestingly, activation of PBMCs with various cytokines showed a decreased sensitivity for TL1A activation in psoriasis patients compared to healthy controls.TL1A levels in blood and biopsies could not be correlated with disease activity with this patient cohort. Thus, additional large‐scale studies are warranted to investigate TL1A as a biomarker. 相似文献
5.
6.
7.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
8.
Fronto-ethmoidal mucocoeles: a histopathological analysis. 总被引:1,自引:0,他引:1
From a series of 118 fronto-ethmoidal mucocoeles, 40 specimens have been submitted to detailed histological analysis. The frequency of each epithelial and sub-epithelial component is considered and reveals features which support a dynamic theory of bone resorption and formation rather than that of pressure erosion in the pathogenesis of mucocoeles. 相似文献
9.
Clinical application of epiderm growth factor in patients with most severe eye burns 总被引:2,自引:0,他引:2
M Reim T Kehrer M Lund 《Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde》1988,197(4):179-184
20 eyes of 11 patients suffering from most severe eye burns of grade 4 or worse were treated in addition to various other drugs with epiderm growth factor (EGF) or placebo in a double-blind test. Among 10 eyes treated with EGF, 6 achieved complete regeneration of the corneal epithelium, and 1 additional case, of the conjunctival epithelium. Among the eyes receiving placebo, only 3 out of 10 healed; all of them were also treated with fibronectin. Although in these very difficult cases EGF could not be investigated as a single therapy, and various other undefined factors may have been effective, in the extended course of the disease the period of EGF treatment was marked by a significant better regeneration of the epithelium. 相似文献
10.
Martin Heine Evgeni Ponimaskin Ulf Bickmeyer Diethelm W. Richter 《Pflügers Archiv : European journal of physiology》2002,443(3):418-426
The HvCNG channel from the moth Heliothis virescens is highly sensitive to cAMP concentrations ranging between 0.1 microM and 5 microM. This HvCNG channel was over-expressed in Spodoptera frugiperda (Sf.9) cells to measure endogenous cAMP levels. Hyperpolarization-activated inward currents were measured in the whole-cell patch-clamp configuration with pipettes filled with different cAMP concentrations to calibrate the system. Varying the cAMP concentration between 0 microM and 100 microM in the pipette, the half-maximal activation voltage ( V1/2) was shifted by +28.5+/-1.7 mV. The activation time constant (tau(a)) was used as a parameter for cAMP quantification because it was independent of the expression level of HvCNG channels. tau(a) changed from 1106+/-60 ms at 0 microM cAMP to 265+/-7 ms at a saturating concentration of 1 mM cAMP. A dose-response relationship yielded values of 0.6 microM for the half-maximal cAMP concentration and 1.5 for the Hill coefficient. Activation of endogenous adenylyl cyclases by 50 microM forskolin induced an elevation of the cAMP level by about 1.6+/-0.2 microM. Co-expressions of HvCNG channels in combination with the mouse 5-HT4a- or 5-HT1A- receptors and the corresponding Gs- or Gi-proteins were successful and allowed us to also verify receptor-induced changes of the cAMP level. Stimulation of m5-HT4a-receptors by 0.1 microM 5-HT induced an increase of cAMP of about 4.6+/-1.5 microM, whereas cAMP levels decreased from a control value of 1+/-0.2 microM to 0.41+/-0.1 microM after stimulation of the m5-HT1A-receptors. 相似文献