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排序方式: 共有2096条查询结果,搜索用时 109 毫秒
1.
Galli Carlo Sala Roberto Colangelo Maria Teresa Guizzardi Stefano 《Scientometrics》2022,127(7):3879-3910
Scientometrics - A literature search on the in vitro testing of anti-inflammatory compounds of natural origin revealed a considerable number of studies adopting a similar template for data... 相似文献
2.
Alessandro Lucidi Danilo Buca Carlo Ronsini Sara Tinari Giuseppina Bologna Davide Buca Martina Leombroni Marco Liberati Francesco DAntonio Giovanni Scambia Paola Lanuti Marco Petrillo 《International journal of molecular sciences》2020,21(22)
Extracellular vesicles (EVs) are a heterogeneous group of cell-derived submicron vesicles released under physiological or pathological conditions. EVs mediate the cellular crosstalk, thus contributing to defining the tumor microenvironment, including in epithelial ovarian cancer (EOC). The available literature investigating the role of EVs in EOC has been reviewed following PRISMA guidelines, focusing on the role of EVs in early disease diagnosis, metastatic spread, and the development of chemoresistance in EOC. Data were identified from searches of Medline, Current Contents, PubMed, and from references in relevant articles from 2010 to 1 April 2020. The research yielded 194 results. Of these, a total of 36 papers, 9 reviews, and 27 original types of research were retained and analyzed. The literature findings demonstrate that a panel of EV-derived circulating miRNAs may be useful for early diagnosis of EOC. Furthermore, it appears clear that EVs are involved in mediating two crucial processes for metastatic and chemoresistance development: the epithelial–mesenchymal transition, and tumor escape from the immune system response. Further studies, more focused on in vivo evidence, are urgently needed to clarify the role of EV assessment in the clinical management of EOC patients. 相似文献
3.
Francesco Di Girolamo Andrea Masotti Isabella Lante Margherita Scapaticci Cosima Damiana Calvano Carlo Zambonin Maurizio Muraca Lorenza Putignani 《International journal of molecular sciences》2015,16(9):20896-20912
Extra virgin olive oil (EVOO) with its nutraceutical characteristics substantially contributes as a major nutrient to the health benefit of the Mediterranean diet. Unfortunately, the adulteration of EVOO with less expensive oils (e.g., peanut and corn oils), has become one of the biggest source of agricultural fraud in the European Union, with important health implications for consumers, mainly due to the introduction of seed oil-derived allergens causing, especially in children, severe food allergy phenomena. In this regard, revealing adulterations of EVOO is of fundamental importance for health care and prevention reasons, especially in children. To this aim, effective analytical methods to assess EVOO purity are necessary. Here, we propose a simple, rapid, robust and very sensitive method for non-specialized mass spectrometric laboratory, based on the matrix-assisted laser desorption/ionization mass spectrometry (MALDI-TOF MS) coupled to unsupervised hierarchical clustering (UHC), principal component (PCA) and Pearson’s correlation analyses, to reveal corn oil (CO) adulterations in EVOO at very low levels (down to 0.5%). 相似文献
4.
In a direct-conversion transmitter system, the nonideal transfer characteristics of practical analog subsystems can have significant adverse effects on the performance of the transmitter system. While a significant body of research exists on correcting static errors (including gain imbalance, phase errors, and DC offsets) in the analog subsystems, relatively little attention has been paid to the impact of nonideal frequency-dependent characteristics in the analog reconstruction filters that are employed in direct-conversion structures. This paper presents a new computationally efficient and numerically robust method for automatic digital compensation for nonideal frequency-dependent characteristics in the signal reconstruction filters of a quadrature (IQ) modulator structure. The new compensation technique is used in conjunction with existing compensation approaches that compensate for static errors. 相似文献
5.
Giulio Croce Paola Dagaro Carlo Nonino 《International Journal of Heat and Mass Transfer》2007,50(25-26):5249-5259
6.
We describe a Gauss–Seidel algorithm for optimizing a three‐dimensional unstructured grid so as to conform to a given metric. The objective function for the optimization process is based on the maximum value of an elemental residual measuring the distance of any simplex in the grid to the local target metric. We analyse different possible choices for the objective function, and we highlight their relative merits and deficiencies. Alternative strategies for conducting the optimization are compared and contrasted in terms of resulting grid quality and computational costs. Numerical simulations are used for demonstrating the features of the proposed methodology, and for studying some of its characteristics. Copyright © 2004 John Wiley & Sons, Ltd. 相似文献
7.
D Pende R Biassoni C Cantoni S Verdiani M Falco C di Donato L Accame C Bottino A Moretta L Moretta 《Canadian Metallurgical Quarterly》1996,184(2):505-518
Human natural killer (NK) cells express inhibitory receptors that are specific for different groups of HLA-C or HLA-B alleles. The majority of these receptors belong to the immunoglobulin (Ig) superfamily and are characterized by two or three extracellular Ig-like domains. Here we describe a novel inhibitory NK receptor that is specific for a group of HLA-A alleles. The HLA-A3-specific NK cell clone DP7 has been used for mice immunization. Two mAbs, termed Q66 and Q241, bound to the immunizing clone and stained only a subset of NK cell populations or clones. Among Q66 mAb-reactive clones, we further selected those that did not express any of the previously identified HLA-class I-specific NK receptors. These clones did not lyse HLA-A3+ (or -A11+) target cells, but lysis of these targets could be detected in the presence of Q66 or Q241 mAbs. On the other hand, target cells expressing other HLA-A alleles, including -A1, -A2, and -A24, were efficiently lysed. Moreover, none of the HLA-C or HLA-B alleles that were tested exerted a protective effect. Q66+, but not Q66- NK cell clones, expressed messenger RNA coding for a novel 3 Ig domain protein homologous to the HLA-C (p58) and HLA-B (p70) receptors. The corresponding cDNA (cl.1.1) was used to generate transient and stable transfectants in COS7 and NIH3T3 cell lines, respectively. Both types of transfectants were specifically stained by Q66 and Q241 mAbs. Since the cytoplasmic tail of Q66-reactive molecules was at least 11 amino acid longer than the other known p58/p70 molecules, we could generate an antiserum specific for the COOH-terminus of Q66-reactive molecules, termed PGP-3. PGP-3 immunoprecipitated, only from Q66+ NK cells, molecules displaying a molecular mass of 140 kD, under nonreducing conditions, which resolved, under reducing conditions, in a 70-kD band. Thus, differently from the other p58/p70 receptors, Q66-reactive molecules appear to be expressed as disulphide-linked dimers and were thus termed p140. The comparative analysis of the amino acid sequences of p58, p70, and p140 molecules revealed the existence of two cysteins proximal to the transmembrane region, only in the amino acid sequence of p140 molecules. 相似文献
8.
9.
Manual responses can be defined by differing response parameters. Any of them may generate a Simon effect. For all those response parameters, the same implementation of the Simon effect (in terms of subserving mechanism) is assumed. In 3 experiments, subjects had to respond with either fingers or sticks. Temporal properties of the Simon effect changed with response parameters relevant in a task. The Simon effect for manual responses decayed. For stick responses, in which the action goal differed from the anatomical mapping of the acting hand, a sustained Simon effect was observed. However, if the action goal for stick responses was not instrumental for selecting the correct response, the Simon effect decayed. The findings are consistent with the notion of different mechanisms involved in generating a Simon effect. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.
We exhibit small size measure-once one-way quantum finite automata (mo-1qfa’s) inducing multiperiodic stochastic events. Moreover, for certain classes of multiperiodic languages, we exhibit: (i) isolated cut point mo-1qfa’s whose size logarithmically depends on the periods; (ii) Monte Carlo mo-1qfa’s whose size logarithmically depends on the periods and polynomially on the inverse of the error probability. 相似文献