Efficacy and Safety of Crisaborole Ointment, 2%, for the Treatment of Mild-to-Moderate Atopic Dermatitis Across Racial and Ethnic Groups

Background

Atopic dermatitis is highly prevalent in black/African American, Asian, and Hispanic patients, making assessment of these populations in clinical trials important. Crisaborole ointment, 2%, is a nonsteroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. In two pivotal phase III clinical trials in patients aged ≥ 2 years, crisaborole was superior to vehicle in reducing global disease severity. The most common treatment-related adverse event was application site pain.

Objective

The objective of this study was to investigate the efficacy and safety of crisaborole according to patient race and ethnicity.

Methods

A pooled post hoc analysis by race and ethnicity of the two pivotal trials and a safety extension trial was performed. Race included white or nonwhite (encompassing Asian/native Hawaiian/other Pacific Islander, black/African American, and other/American Indian/Alaskan native); ethnicity included Hispanic/Latino or not Hispanic/Latino.

Results

In white, nonwhite, Hispanic/Latino, and not Hispanic/Latino groups at day 29, more crisaborole- than vehicle-treated patients achieved improvements in global disease severity [Investigator’s Static Global Assessment of clear/almost clear with a ≥ 2-grade improvement (white: 33.5% vs. 22.3%, nominal p < 0.001; nonwhite: 30.0% vs. 21.3%, nominal p < 0.05; Hispanic/Latino: 35.4% vs. 18.2%, nominal p < 0.01; not Hispanic/Latino: 31.3% vs. 22.8%, nominal p < 0.01)]. Crisaborole treatment also improved atopic dermatitis signs/symptoms and quality of life. Frequency of crisaborole-related adverse events was 7.1–8.5% in the pivotal trials.

Conclusion

Across races and ethnicities, crisaborole demonstrated efficacy for the treatment of mild-to-moderate atopic dermatitis, with a low frequency of treatment-related adverse events.

     

Efficacy and Safety of Brodalumab in Patients with Moderate-to-Severe Plaque Psoriasis and Skin of Color: Results from the Pooled AMAGINE-2/-3 Randomized Trials

American Journal of Clinical Dermatology - Data on treatment outcomes in patients with psoriasis who have skin of color are limited. Brodalumab has shown efficacy in patients with...     

Hyperpigmentation Therapy: A Review

With an increasing number of multicultural patients and those of different backgrounds presenting in dermatology clinics, issues facing patients with higher Fitzpatrick skin classifications, often referred to as skin of color patients, are on the rise. Knowledge of the diagnostic dilemmas, cutting edge treatment options, and latest clinical research in the diagnosis and management of cutaneous anomalies in skin of color patients is of paramount importance. Of the most common complaints in patients with skin of color is hyperpigmentation. Despite the availability of multiple treatments for the condition, hyperpigmentation continues to present clinical management challenges for dermatologists. Difficulty may be traced to physician or patient reluctance to use certain agents or interventions, failure to identify and avoid contributing factors, and insufficient attention paid to the psychosocial aspects of the disease. This review addresses a variety of issues including the diagnosis and management of hyperpigmentation.Message from Seemal R. Desai, MD, FAADDisorders of pigmentation, dyschromias, scarring from acne, and other conditions, along with a host of other dermatoses are treatment challenges that all dermatologists face on a daily basis. Dr. Andrew Alexis and I are honored to serve as the Section Editors of the new Skin of Color Special Section of The Journal of Clinical and Aesthetic Dermatology and would like to personally thank Dr. Jim Del Rosso for welcoming this increasingly relevant topic into this highly respected journal. We welcome your ideas, comments, and suggestions for future pieces that you think would be valuable in treating your patients with skin of color and hope that this first article on hyperpigmentation will pique your interest in the topic of skin of color and its diagnosis and management. Whenever approaching patients with skin of color, it is important to understand that no single therapy exists to achieve the perfect balance of skin lightening and maintaining cutaneous integrity. This mantra is most relevant in the treatment of hyperpigmentation, including melasma, postinflammatory pigmentary alteration, drug-induced causes, or other etiologies. The bottom line is that it is important to keep an open mind regarding a multi-therapy approach, possibly involving in-office based procedures, and/or newer more literature-based treatment modalities.