全文获取类型
收费全文 | 4376篇 |
免费 | 502篇 |
国内免费 | 9篇 |
学科分类
医药卫生 | 4887篇 |
出版年
2023年 | 79篇 |
2022年 | 60篇 |
2021年 | 330篇 |
2020年 | 156篇 |
2019年 | 243篇 |
2018年 | 271篇 |
2017年 | 188篇 |
2016年 | 160篇 |
2015年 | 216篇 |
2014年 | 249篇 |
2013年 | 218篇 |
2012年 | 353篇 |
2011年 | 328篇 |
2010年 | 176篇 |
2009年 | 139篇 |
2008年 | 231篇 |
2007年 | 188篇 |
2006年 | 158篇 |
2005年 | 175篇 |
2004年 | 140篇 |
2003年 | 114篇 |
2002年 | 97篇 |
2001年 | 43篇 |
2000年 | 33篇 |
1999年 | 29篇 |
1998年 | 19篇 |
1997年 | 11篇 |
1996年 | 12篇 |
1994年 | 13篇 |
1993年 | 9篇 |
1992年 | 36篇 |
1991年 | 27篇 |
1990年 | 23篇 |
1989年 | 16篇 |
1988年 | 25篇 |
1987年 | 35篇 |
1986年 | 23篇 |
1985年 | 26篇 |
1984年 | 14篇 |
1983年 | 15篇 |
1981年 | 10篇 |
1979年 | 11篇 |
1978年 | 13篇 |
1977年 | 13篇 |
1976年 | 19篇 |
1974年 | 11篇 |
1969年 | 11篇 |
1968年 | 11篇 |
1965年 | 8篇 |
1963年 | 10篇 |
排序方式: 共有4887条查询结果,搜索用时 15 毫秒
1.
2.
3.
Facundo Davaro Jacob Roberts Allison May Coleman McFerrin Sameer Siddiqui Zachary Hamilton 《Journal of robotic surgery》2020,14(3):447-454
Partial nephrectomy is the mainstay of treatment for localized kidney cancer. A proportion of patients are upstaged post-operatively to locally advanced di 相似文献
4.
Beyond C4d: Other Complement-Related Diagnostic Approaches to Antibody-Mediated Rejection 总被引:3,自引:0,他引:3
William M. Baldwin III Edward K. Kasper rea A. Zachary Barbara A. Wasowska E. Rene Rodriguez 《American journal of transplantation》2004,4(3):311-318
Complement is a multifunctional system of receptors and regulators as well as effector molecules. Both the pathogenic and diagnostic power of complement is based on the capacity of the complement system to amplify innate and adaptive immunity. This amplification is accomplished through two strategies: (1) enzymatic reactions in the complement cascade, and (2) stimulation of leukocytes, platelets and parenchymal cells through specific receptors or receptor-independent pore formation. The mechanisms by which complement mediates and modifies nonspecific inflammation, antibody-mediated injury and T-cell responses are of particular significance to the pathogenesis of transplant rejection. Understanding the mechanisms by which complement integrates the interactions of leukocytes, platelets and parenchymal cells offers opportunities to further refine the diagnosis of rejection. 相似文献
5.
Proteins that enter the secretory pathway play important roles in virulence and pathogenesis in Candida albicans, but our understanding of the trafficking of these proteins is in its early stages. In Saccharomyces cerevisiae, dominant negative alleles of YPT1 and SEC4 interrupt secretory traffic at pre- and post-Golgi steps, respectively. We therefore used a dominant negative genetic approach to examine the intracellular trafficking of several proteins associated with virulence or azole resistance. When the dominant negative ypt1(N121I) allele of C. albicans was overexpressed, yellow-fluorescent protein (YFP) tagged forms of two plasma membrane transporters (Cdrlp and Ftrlp) and the vacuolar membrane ABC transporter Mltlp accumulated in intracellular structures that appeared related to the ER, but localization of Cdc10p and Int1p was unaffected. When the dominant negative sec4(S28N) allele of C. albicans was overexpressed, Cdrlp and Ftrlp accumulated intracellularly, and localization of Mltlp, Cdc10p and Int1p was unaffected. These results imply that (i) Cdrlp and Ftrlp are transported to the plasma membrane by the general secretory pathway, (ii) Mlt1p enters the secretory pathway but is diverted to the vacuole at an early post-Golgi step, and (iii) like Cdc10p, Int1p does not enter the general secretory pathway. 相似文献
6.
Thromboxane, a prostanoid derivative, is a central mediator of the progressive dermal ischemia seen in the distal dying flap. Prostacyclin; a vasoactive prostanoid derivative, has been found to enhance ischemic flap survival. This study examines the effects of prostacyclin and UK 38485 (specific thromboxane synthetase inhibitor), separately and combined, in axial flap survival in the pig. Each increased flap survival over control flaps; their combined use demonstrated an even greater flap survival (p less than 0.005). 相似文献
7.
8.
The effect of a carbon dioxide pneumoperitoneum on rabbit follicular oocytes and early embryonic development 总被引:1,自引:0,他引:1
C Mastroyannis Y Hosoi Y Yoshimura S J Atlas E E Wallach 《Fertility and sterility》1987,47(6):1025-1030
The effect of a carbon dioxide (CO2) pneumoperitoneum and its duration on rabbit follicular oocytes was assessed by evaluating fertilization and subsequent embryonic development rates. CO2 may cross the plasma membrane and form carbonic acid, which liberates H+, thus lowering the intracellular pH. There were no significant differences in arterial pH and [HCO3-] between CO2 and air treatment groups, whereas arterial pCO2 and pO2 were significantly increased in the CO2 treatment group. We found that the duration of pneumoperitoneum, irrespective of type of gas used, was negatively correlated with success of embryonic development. These findings necessitate that more attention be given to the gas used for creation of a pneumoperitoneum during egg retrieval for in vitro fertilization and an attempt be made to minimize duration of the pneumoperitoneum. 相似文献
9.
A S Mark P Blake S W Atlas M Ross D Brown M Kolsky 《AJNR. American journal of neuroradiology》1992,13(5):1463-1470
PURPOSE: To describe a radiographic finding--enhancement of the cisternal portion of the third cranial nerve on postcontrast MR--and to correlate it with patients' clinical symptoms and ultimate diagnosis. MATERIALS AND METHODS: Thirteen consecutive patients with enhancement of the cisternal portion of the third cranial nerve on postcontrast MR were retrospectively identified; 50 control patients referred for pituitary microadenomas were also retrospectively reviewed. FINDINGS: The enhancement was bilateral in six patients and unilateral in seven patients. Four of the six patients with bilateral enhancement had unilateral oculomotor nerve palsies; none had bilateral third cranial nerve palsy. Five of the seven patients with unilateral enhancement had ipsilateral third nerve palsies. Of the nine patients with third nerve palsies, the pupil was involved in four patients. Follow-up studies were available in six patients, four of whom had third nerve palsy. Resolution of the enhancement correlated with resolution of the symptoms in two patients. The patients' underlying diagnoses were lymphoma (four), leukemia (one), viral meningitis (one), neurofibromatosis (two), inflammatory polyneuropathy-HIV related (one), ophthalmoplegic migraine (one), Tolosa-Hunt syndrome (one), coccidioidomycosis (one), and diabetes (one). No enhancement was seen in any of the controls. CONCLUSION: Enhancement of the cisternal segment of the third cranial nerve is always abnormal, revealing an underlying inflammatory or neoplastic process. However, it is not always associated with clinically apparent oculomotor nerve dysfunction. 相似文献
10.