锁骨下动脉损伤及创伤性假性动脉瘤手术方法探讨

目的探讨锁骨下动脉损伤及创伤性动脉瘤的外科治疗方略。方法1991—2005年对2例锁骨下动脉损伤，6例锁骨下假性动脉瘤根据病变的部位、程度及受伤时间、累及范围等选择手术入路，采用血管缝扎、血管壁修补、血管吻合、血管移植、辅助体外循环及球囊止血技术实施手术。结果6例痊愈，1例动静脉狭窄，1例动脉闭塞伴臂丛损伤。平均失血800mL。结论锁骨下动脉损伤及假性动脉瘤手术复杂，术前对病变进行仔细评估，选择合理的切口及手术方法是减少并发症的关键。     

大肠癌组织中细胞胀亡及MMP-2检测

目的 :检测大肠癌组织中胀亡细胞及MMP - 2。方法 :应用透射电镜和免疫组化方法检测 5 1例大肠癌组织中胀亡细胞和MMP - 2的表达。结果 :①大肠癌组织中可检测到不同时期的胀亡细胞。②大肠癌组织中MMP- 2表达率 5 4 .9% (2 8/ 5 1 ) ,明显高于正常大肠粘膜 (P <0 .0 5 )。③MMP - 2在淋巴结转移组的阳性表达率为 6 9.5 7% (1 6 / 2 3) ,明显高于无淋巴结转移组的 4 2 .86 % (1 2 / 2 8) ;有淋巴结转移组胀亡指数明显低于无淋巴结转移组 (P<0 .0 5 )。④MMP - 2表达阳性组OI高于MMP - 2阴性组。结论 :大肠癌组织中存在胀亡细胞和MMP - 2的表达 ,2者关系密切 ,且均与大肠癌的转移有关。     

Expression of autocrine motility factor correlates with the angiogenic phenotype of and poor prognosis for human gastric cancer.

Autocrine motility factor (AMF) is a cytokine known to regulate tumor cell motility. Recent studies have extended its role to many other aspects of cancer biology. In the present study, we examined the level of AMF expression and its relationship with vascular endothelial growth factor (VEGF) expression and the angiogenic phenotype in human gastric cancer and their effect on survival. The AMF and VEGF expression level and tumor microvessel density (MVD) status in archived tissue specimens from 86 resected gastric cancer cases were determined. AMF expression was significantly higher in both primary tumors and lymph node metastases than in adjacent normal gastric mucosa and normal gastric mucosa from individuals without gastric cancer. In univariate survival analyses, strong AMF expression was associated with inferior survival (P = 0.028). In a Cox proportional hazards model, strong AMF expression (P = 0.019) was independently prognostic of poor survival. Strong AMF expression in the lymph node metastases was associated with poor survival (P = 0.011). Furthermore, AMF expression in the primary tumors was directly correlated with VEGF expression and MVD status. We found the first clinical evidence that AMF expression is directly correlated with VEGF expression and MVD status and predicts clinical outcome in patients with gastric cancer, supporting the hypothesis that the AMF/AMF receptor pathway plays an important role in multiple aspects of cancer biology.     

Q.STATIC呼吸门控与非门控扫描肺结节的临床价值:65例前瞻性研究

目的比较Q.STATIC呼吸门控（QSRG）与非门控(UG)扫描对肺结节图像质量、定量分析的影响，评价其临床应用价值。方法本项前瞻性研究纳入2019年11月~2020年5月疑诊肺结节且同意行QSRG采集患者65例，共295个肺结节，有4例患者因持续呼吸不规律未能完成门控检查而排除。记录QSRG和UG下可测量肺结节的最大标准摄取值（SUV_max）、肿瘤代谢体积（MTV）、平均标准摄取值（SUV_mean）、主动脉弓标准差值和临床扫描时间。比较QSRG和UGPET在肺结节检出、可测量肺结节、SUV_max、MTV、信噪比（SNR）和临床扫描时间的差异。结果QSRGPET和UGPET的PET肺结节检出肺结节数、可测量肺结节数、SUV_max、MTV、SNR和扫描时间分别为295个vs 275个、196个vs 182个、6.90±4.40g/mL vs 6.64±4.28g/mL（P < 0.05）、3.23±8.01cm3 vs 3.44±8.66cm3（P < 0.05）、30.30±20.91 vs 30.22±21.97（P>0.05）、16.45±3.74min vs 13.21±3.98min（P < 0.05），单个床位QSRG增加全身扫描的时间为3min。结论QSRG不增加放射性剂量，与UG图像相比，QSRG图像肺结节检出率和可测量能力更高，SUV_max和MTV定量分析更准确，稍有所增加总扫描时间。      

Correction to: Identification of prognostic factors and construction of a nomogram for patients with relapse/refractory adult-onset Still’s disease

Clinical Rheumatology -     

Comparison of the efficacy and safety of the adalimumab biosimilar TQ-Z2301 and adalimumab for the treatment of Chinese patients with active ankylosing spondylitis: a multi-center,randomized, double-blind,phase III clinical trial

Clinical Rheumatology - To assess the clinical equivalence of TQ-Z2301, a biosimilar of adalimumab, to the reference adalimumab in the treatment of Chinese patients with active ankylosing...     

不同类型感染性骶髂关节炎临床表现与影像学特点分析

总结并分析不同类型感染性骶髂关节炎的临床与影像学特点。回顾性分析40例感染性骶髂关节炎患者的临床资料,其中非布鲁菌非结核性感染性骶髂关节炎(ISI)16例,结核性骶髂关节炎(TSI)13例,布鲁菌感染性骶髂关节炎(BSI)11例。ISI者中女性11例,TSI者中女性12例。ISI者中骶髂关节单侧受累15例,TSI者中12例。与ISI者、TSI者比,BSI者男性(8例)和骶髂关节双侧受累(6例)多见。磁共振成像(MRI)见骨侵蚀ISI者6例,TSI者7例,BSI者2例;MRI见脓肿形成ISI者3例,TSI者4例,BSI者1例。40例患者经抗感染和抗结核治疗后症状多于1~2周缓解,但MRI恢复较慢,3例(2例ISI者,1例BSI者)患者治疗6(3~9)个月复查MRI基本正常,8例(4例ISI者,4例TSI者)患者治疗3.5(2~18)个月复查MRI仍异常。ISI、TSI多为骶髂关节单侧受累,女性多见,骶髂关节骨质破坏明显,周围软组织受累及脓肿形成多见。BSI较少出现骨质破坏及脓肿形成。感染性骶髂关节炎患者MRI影像学恢复滞后于临床表现。     

Myocardial involvement in idiopathic inflammatory myopathies: a multi-center cross-sectional study in the CRDC-MYO Registry

Clinical Rheumatology - This study aimed to investigate the associated factors of myocardial involvements (MIs) in patients with idiopathic inflammatory myopathies (IIMs). In this multi-center...     

基于PKC通路调控的P2X3受体在疼痛中的研究进展

疼痛作为临床上最常见的症状之一,极大地影响了患者的行为与情绪。本文总结了目前P2X3受体基于PKC通路在疼痛机制中的研究,为疼痛的研究和治疗提供思路。     

降钙素原对自身免疫性疾病患者合并细菌感染的诊断价值

目的探讨降钙素原对自身免疫性疾病(autoimmune disease,AID)患者合并细菌感染的诊断价值。方法检测181例确诊AID患者的降钙素原(procalcitonin,PCT)、C反应蛋白(C-reaction protein,CRP)、红细胞沉降率(erythrocyte sedimentation rate,ESR)及白细胞计数,比较上述指标诊断细菌感染的敏感性及特异性,评价PCT对于细菌感染的诊断价值。结果 AID患者合并细菌感染组PCT、CRP较非感染组高(P<0.05),两组WBC和ESR差异无统计学意义(P>0.05),ROC曲线提示PCT诊断AID合并细菌感染具有更高的特异性和敏感性。病情稳定的SLE合并细菌感染组PCT、CRP均高于非感染组(P<0.05),ROC曲线提示CRP诊断病情稳定的SLE合并细菌感染的特异性和敏感性高于PCT。结论 PCT在AID合并细菌感染中具有诊断价值,并受疾病种类及病情活动度影响。