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Gallogly Susan Fujisawa Takeshi Hung John D. Brittan Mairi Skinner Elizabeth M. Mitchell Andrew J. Medine Claire Luque Neus Zodda Erika Cascante Marta Hadoke Patrick W. Mills Nicholas L. Tura-Ceide Olga 《Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy》2021,35(6):1281-1290
Cardiovascular Drugs and Therapy - Endothelial dysfunction is central to the pathogenesis of acute coronary syndrome. The study of diseased endothelium is very challenging due to inherent... 相似文献
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Erkan Cure Medine C. Cure Levent Tumkaya Yildiray Kalkan Ibrahim Aydin Aynur Kirbas Arif Yilmaz Suleyman Yuce Mehmet F. Gokce 《Saudi Journal Of Gastroenterology》2014,20(5):297-303
Background and Aim:
Ischemia/reperfusion (I/R) injury in the liver occurs after a prolonged period of ischemia followed by restoration of hepatic blood perfusion. During the surgery of abdominal aorta, I/R injury causes damage to lower extremities and many organs, especially liver. The antioxidant and tumor necrosis factor-alpha (TNF-α) suppression effects of topiramate (TPM) have been reported in several studies. We evaluated the potential protective effect of TPM on cellular damage in liver tissue during I/R injury.Materials and Methods:
Thirty male Wistar albino rats were divided into three groups: Control, I/R, and I/R plus TPM (I/R + TPM) groups. Laparotomy without I/R injury was performed in the control group. After laparotomy, cross-ligation of infrarenal abdominal aorta was applied for 2 h in I/R groups that was followed by 2 h of reperfusion. TPM (100 mg/kg/day) was orally administrated to the animals in the I/R + TPM group for seven consecutive days before I/R procedure.Results:
The I/R group''s TNF-α and interleukin-6 (IL-6) levels were significantly higher than those of the control (P = 0.010; P = 0.002) and I/R + TPM groups (P = 0.010; P = 0.002, respectively). Asymmetric dimethyl arginine (ADMA) levels of I/R group were higher than the control (P = 0.015) and I/R + TPM groups. I/R caused serious histopathological damage to liver tissue; however, TPM led to very low histopathological changes.Conclusion:
Our data demonstrated that TPM treatment prominently decreases the severity of liver I/R injury. TPM pretreatment may have preventive effects on liver injury via I/R during intra-abdominal surgery. 相似文献4.
Serdar Özkasap Kemal Türkyilmaz Selim Dereci Veysi Öner Tuğba Calapoğlu Medine Cumhur Cüre Mustafa Durmuş 《Child's nervous system》2013,29(12):2281-2286
Purpose
Vitamin B12 deficiency is a worldwide problem. It affects all ages, including children. It is one of the most common nutritional disorders and can cause harmful effects on the nervous system. In this study, we compared the peripapillary retinal nerve fiber layer thickness (RNFLT) in a healthy control group with children with vitamin B12 deficiency. In our study, we aimed to evaluate the effect of vitamin B12 deficiency on the RNFLT in children with the optical coherence tomography (OCT) method.Methods
Sixty-six children with a diagnosis of vitamin B12 deficiency (patient group) and 66 age- and sex-matched healthy children (control group) were enrolled in this prospectively designed study. Blood counts, vitamin B12 levels, folate levels, and full biochemical parameters were obtained for all the subjects in each group. Peripapillary RNFLT measurements were performed with Cirrus HD spectral domain OCT.Results
The thickness of the superior retinal nerve fiber layer (RNFL) in the vitamin B12 deficiency group was significantly lower than that of the control group (p?=?0.037). Although the average thickness of the RNFL was lower in the patient group, there was no statistically significant differences (p?=?0.216). In the vitamin B12 deficiency group, the average RNFL thickness and the superior RNFL thickness were significantly correlated with vitamin B12 levels (r 1?=?0.353, p 1?<?0.004 and r 2?=?0.416, p 2?=?0.001, respectively).Conclusion
Our study showed that a deficiency in vitamin B12, elsewhere it is important for the development of the central nervous system, is associated with a reduction in the thickness of the superior RNFL. 相似文献5.
Fatma Yurt Lambrecht Erhan Kayaalp Perihan Unak Hüseyin Enginar F. Zümrüt Biber Muftuler E. Ilker Medine Berkan Cetinkaya 《Medicinal chemistry research》2007,16(7-9):427-435
Multiple-drug therapy is common in current clinical practice. Because of this, people have been ready to embrace simplistic
approaches to cold treatment, such as vitamin C and zinc. Ascorbic acid (vitamin C) is mostly administrated together with
cough–cold drugs. The aim of this study was to investigate the effect of cough–cold drugs on the uptake of ascorbic acid using
99mTc-ascorbic acid (99mTc-AA) in male albino Wistar rats. Ascorbic acid was labeled with Tc-99m and the distribution of 99mTc-AA was investigated. The uptake of 99mTc-AA was evaluated when administrated alone (group I), with chlorpheniramine maleate (CPR) (group II), with phenylpropanolamine
hydrochloride (PPA) (group III), and with acetaminophen (APAP) (group IV). In some organs (apart from kidneys, intestinal
system, and stomach) the uptake of 99mTc-AA was not significantly affected by the administration of 99mTc with CPR or 99mTc with APAP at 120 min. On the other hand, there was significant difference in the uptake of 99mTc-AA between groups I and III. The administration of 99mTc-AA with PPA in rats caused an increase of the uptake of 99mTc-AA at 120 min in the investigated organs compared to the administration of 99mTc-AA alone. The present data show that vitamin C might be more effective for the treatment of common cold when coadministered
with PPA compared to with CPR, with APAP, or alone. 相似文献
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The aim of our study was to use an in vivo radiopharmaceutical model to investigate the cytoprotective effect of amifostine against doxorubicin-induced cardiotoxicity. Male Wistar rats were randomly divided into four groups (n = 6): 1) Saline (control); 2) Doxorubicin (DOX; 10 mg/ kg(-l) intraperitoneally); 3) Amifostine (AMI; 200 mg/kg(-1) intraperitoneally); 4) Doxorubicin plus amifostine (DOX + AMI). Amifostine was injected 30 minutes before doxorubicin in Group 4. 99mTc-MIBI, 20 MBq/0.2 ml(-1), was injected through the tail vein 72 hours after the drug administration. Rats were killed and samples of myocardium were removed by dissection 60 minutes after the injection of radiopharmaceutical. Radioactivity in each organ sample was counted using a Cd(Te) detector equipped with RAD 501 single-channel analyzer. The percent radioactivity was expressed as a percentage of the injected dose per gram of tissue (%ID/g(-1)). The %ID/g(-1) activity was calculated by dividing the activity in each sample by the total activity injected and mass of each organ. 99mTc-MIBI uptake as %ID/g(-1) was 1.194 +/- 0.502 and 0.980 +/- 0.199 in the control and AMI groups, respectively. Doxorubicin administration resulted in a significant increase in %ID/ g(-1) (3.285 +/- 0.839) (p < 0.05). Amifostine administration 30 minutes before doxorubicin injection resulted a significant decrease in %ID/g(-1) (2.160 +/- 0.791) (p < 0.05) compared with doxorubicin alone. The results showed that amifostine significantly attenuated doxorubicin-induced cardiotoxicity. 相似文献
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OBJECTIVES: The purpose of this study was to examine the underlying temperament and character properties of patients with bipolar disorder and explore the possible connections between these properties and clinical presentation of the illness. METHODS: The sociodemographic and clinical properties of 90 patients with bipolar disorder, who were euthymic according to Young Mania Rating Scale and Hamilton Depression Scale scores, were recorded. Their temperament and character features were evaluated by using Temperament and Character Inventory and results were compared with 90 age- and sex-matched healthy controls and between patients with different clinical properties. RESULTS: Patients' scores on subscales of self-directedness and cooperativeness were significantly lower compared with controls. Significant associations were found between Temperament and Character Inventory subtitles and comorbid personality disorder, number of episodes, subtype of the first episode, rapid cycling, and previous suicide attempt. CONCLUSIONS: Temperament and character features of patients with euthymic bipolar disorder show some significant differences compared to the healthy population and may vary according to different clinical presentations. 相似文献
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Teksöz S Içhedef CA Ozyüncü S Müftüler FZ Unak P Medine IE Ertay T Eren MŞ 《Cancer biotherapy & radiopharmaceuticals》2011,26(5):623-630
The current study was aimed at synthesizing a glucuronide derivative of D-penicillamine (D-PA) to be used for imaging purposes. First of all, D-PA-glucuronide (D-PA-Glu) was synthesized by experimental treatments starting with uridine 5'-diphospho-glucuronosyltransferase enzyme rich microsome preparate. Then, the synthesized compound was labeled with technetium ((99m)Tc) by using a reduction method with stannous chloride. Quality controls were performed by using high-performance liquid chromatography and thin-layer radio chromatography (TLRC). Radiolabeling yield of (99m)Tc-D-PA-Glu was more than 98% according to TLRC results. In vitro evaluations of radiolabeled complexes were investigated on PC-3 human prostate cancer cells. (99m)Tc-D-PA-Glu exhibited more accumulation on PC-3 cells versus (99m)Tc-D-PA at 240 minutes. In order to determine its radiopharmaceutical potential, biodistribution studies were carried out in male Albino Wistar rats. The biodistribution results of (99m)Tc-D-PA-Glu, showed the highest uptake in prostate at 120 minutes postinjection with the main excretion route being through kidneys and bladder. (99m)Tc-D-PA-Glu and (99m)Tc-D-PA have exhibited different biodistribution results. 相似文献
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Derya Hopanci Bicakli Msc RD Medine C. Yilmaz PhD RN Serap Aksoylar MD Mehmet Kantar MD Nazan Cetingul MD Savas Kansoy MD 《Pediatric blood & cancer》2012,59(7):1327-1329
We aimed to demonstrate whether enteral nutrition (EN) is feasible in daily practice of hematopoietic stem cell transplantation (HSCT).Nutritional records of 100 patients were evaluated. Patients with poor oral intake were fed by EN with tube. A total of 79 patients required nutritional support. Of them, 71 were fed by EN only. Five were fed by EN plus parenteral nutrition (PN),three were fed by PN only. Median duration of EN was 21 days. In the EN only group, 68% gained or maintained their weight. EN should be considered as a feasible option for nutrition support in children undergoing HSCT. Pediatr Blood Cancer 2012; 59: 1327–1329. © 2012 Wiley Periodicals, Inc. 相似文献