结合龙胆泻肝丸治疗急性虹膜睫状体炎

急性虹膜睫状体炎是累及虹膜睫状体的急性疾病，是眼科常见的急重病症，也是致盲眼病之一。多发于青壮年且反复发作，久而久之视力渐降甚至可致失明，常规治疗包括散瞳、热敷、肾上腺皮质激素、抗生素及前列腺素抑制剂应用等。笔者于2005年3月-2006年3月用龙胆泻肝丸联合常规西药治疗本病42例，并与单纯用西药治疗30例进行了回顾性比较，结果前者疗效显著，能更有效地控制病情，减少复发，并且具有疗程短、费用低等特点。现报告如下。     

发育性青光眼误漏诊12例分析

即便进入了21世纪，青光眼这种致盲性疾病仍然会漏诊误诊，特别是发育性青光眼更为常见。我院眼科门诊在2004年至今遇到12例患者，现报告如下。     

晚发性抑郁症与血管紧张素转化酶基因多态性关系研究

目的 探讨晚发性抑郁症（LOD）与血管紧张素转换酶（ACE）基因第16内含子中Alu重复序列的插入/缺失（Insertion/Deletion，I/D）多态性的关系。方法 入组183例60-86岁老年人，晚发性抑郁症组（93例，下称LOD组）和正常对照组（90例，下称对照组），用聚合酶链式反应（PCR）法进行ACE基因I/D多态性分型。结果LOD组和对照组间基因型频率及等位基因频率分布差异无显著（X^2=0.241，P=0.886；X^2=0.127，P=0.722），各基因型亚型患者在年龄、性别、发病次数、病程、HAMD评分、有无精神病性症状、有无自杀企图间差异无显著（P均〉0.05）。结论ACE基因I/D多态性与晚发性抑郁症无显著相关性。     

两种静脉留置针置管在危重症患儿中的应用效果与安全性比较

目的:探讨两种静脉留置针置管在危重症患儿中的应用效果与安全性.方法:将86例危重症患儿随机分为观察组与对照组各43例,观察组给予股静脉留置针置管术,对照组给予外周浅静脉留置针置管术.观察两组患儿留置针保留时间与并发症情况.结果:观察组保留时间明显长于对照组(P＜0.01),并发症发生率明显低于对照组(P＜0.01).结论:股静脉留置针置管具有较好的留置效果和较高的安全性,提高了医护人员工作效率,适合于危重症患儿的治疗.     

脑源性神经营养因子Val66Met功能基因多态性与环境因素对抗抑郁剂临床疗效的影响

Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P ＞0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P＞0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment.     

脑源性神经营养因子Val66Met功能基因多态性与环境因素对抗抑郁剂临床疗效的影响

Objective To explore the effect of brain-derived neurotrophic factor (BDNF) Val66Met polymorphism,environmental factor and their interactions on antidepressant treatment.Methods 340 patients of major depressive disorder (MDD) who met the diagnosis criteria of MDD ( DSM-Ⅳ Axis Ⅰ) were recruited.280 patients of them were finished 12 weeks antidepressant treatment.The severity of depression was measured with the Hamilton Depression Rating Scale (HDRS) before and after 12 weeks antidepressant treatment.Childhood Trauma Questionnaire,28-item Short Form (CTQ-SF) and Life Events Scale (LES) were used to evaluate childhood adverse and life stress before onset.Genotyping of BDNF Val66Met polymorphism was detected by Illumina GoldenGate assays.Results Male patients proportion were significantly higher in non-remitters than remitters (P =0.008 ).After adjusting by gender, the frequencies of genotype and allele for the BDNF Val66Met polymorphism were no significant difference between remitters (AA: AG: GG = 28: 79: 40, A:G = 135:159 ) and non-remitters (AA: AG: GG = 29:81:23 ,A: G = 139:127 ) (P ＞0.05 ).There was no significant difference of CTQ scores and LES scores between the two groups (P＞0.05 ).The regression analysis showed that social intercourse problem and age were the risk factor for the severity of depression.The gender, HDRS baseline scores and mental disorder family history were associated with the efficacy of 12 weeks antidepressant.However,there was no significantly relationship between the interaction of BDNF Val66Met polymorphism and environment with the antidepressant treatment.Conclusion The older men with the mental disorder family history, severe depression symptom would be less-response to antidepressant treatment.However, BDNF Val66Met polymorphism, childhood trauma, life events stress and the interaction of BDNF Val66Met polymorphism and environment have no significantly effect on the 12 weeks antidepressant treatment.     

复方血栓通胶囊治疗视网膜静脉阻塞69例

目的观察补气、清热凉血、化瘀止血、活血祛瘀的药物合用治疗视网膜静脉阻塞的疗效。方法69例患者均服用中成药复方血栓通胶囊,药物组成黄芪、三七、丹参、玄参。结果总有效率为93%。提示该药对本病具有改善视野及视网膜血液循环促进局部炎症、出血、渗出物的消散和吸收。     

抑郁症病因学和治疗学的研究进展

抑郁症(major depressive disorder,MDD)以情感低落或兴趣减退为主要临床特征,并伴有认知、行为、生物学紊乱和躯体症状.抑郁症的终身患病率为15%～17%,年患病率6%～7%,全球患者高达3.4亿.     

96例先天性泪囊炎治疗分析

2008年8月至2010年8月我院眼科门诊治疗先天性泪囊炎96例,其中男性52例(54.2%),单眼患病72例(75.0%)。年龄20天至18个月,6个月以下者76例(54.2%)。所有患儿在出生后5~10天出现流泪,15~60天眼部出现较多分泌物,排除倒睫、急性结膜炎,压迫泪囊区有黏液或脓液自泪点溢出。     

龙胆泻肝丸在眼科中的应用

笔者临床上将龙胆泻肝丸用于肝胆实火所致的多种眼病，疗效显著，现举4例如下。