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1.
Éktova L. V. Goryunova O. V. Eremina V. A. Tikhonova N. I. Medvedeva L. A. 《Pharmaceutical Chemistry Journal》2019,53(7):604-609
Pharmaceutical Chemistry Journal - Use of formylindolylacetic acid as a reagent at the stage of preparing the glycosides of bis(indolyl)furan-2,5-diones and dioxane as solvent increased yields from... 相似文献
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Donor insemination: child development and family functioning in lesbian mother families 总被引:1,自引:5,他引:1
Brewaeys A; Ponjaert I; Van Hall EV; Golombok S 《Human reproduction (Oxford, England)》1997,12(6):1349-1359
Findings are presented of a comparative study investigating the family
relationships and the emotional and gender development of children raised
in lesbian mother families. A total of 30 lesbian mother families with 4-8
year old children created as a result of donor insemination (DI) were
compared with 38 heterosexual families with a DI child and with 30
heterosexual families who had a naturally conceived child. A variety of
assessment measures, including a standardized interview and questionnaires
from the parents and psychological testing of the child were used to
collect the data. The quality of the couples' relationships and the quality
of the mother-child interaction did not differ between lesbian mother
families and either of the heterosexual family groups. The quality of the
interaction between the social mother and the child in lesbian families was
superior to that between the father and the child in both groups of
heterosexual families. Childrens' own perception of their parents was
similar in all family types; the social mother in lesbian families was
regarded by the child to be as much a 'parent' as the father in both types
of heterosexual families. With regard to their emotional/behavioural
development, boys and girls raised in lesbian mother families were well
adjusted and their gender role development did not differ from that of
children raised in heterosexual families. These results indicate that child
and family development in lesbian mother families is similar to that of
heterosexual families.
相似文献
6.
Donor insemination: Dutch parents' opinions about confidentiality and donor anonymity and the emotional adjustment of their children 总被引:1,自引:4,他引:1
Brewaeys A; Golombok S; Naaktgeboren N; de Bruyn JK; van Hall EV 《Human reproduction (Oxford, England)》1997,12(7):1591-1597
Results from a comparative study investigating 38 donor insemination (DI)
Dutch families with 4-8 year old children are presented. The aims of this
study were to investigate parents' opinions on the issues of
confidentiality and donor anonymity, to assess the emotional development of
the children, and to examine in DI families the association between secrecy
with regard to the use of a donor and the emotional adjustment of the
children. The DI families were compared to families with a child conceived
by in-vitro fertilization (IVF) and to families with a naturally conceived
child. Secrecy appeared to be associated with DI and not with IVF: 74% of
the DI parents intended not to inform the child about the way in which
she/he was conceived, whereas none of the IVF parents intended to keep the
secret. Only one set of DI parents and two sets of IVF parents had actually
told the child. As to donor anonymity, a spread of opinions appeared among
DI parents; 57% preferred an anonymous donor, 31% would have liked non-
identifying information about the donor, 9% preferred the donor's identity
to be registered and 3% remained unsure. Parents' major concern was to know
more about the medical/genetic background of the donor. Mothers and fathers
in the DI families differed in their opinions concerning the issues of
confidentiality and donor anonymity: fathers, more often than mothers, were
secretive with regard to the use of a donor and husbands, more often than
their wives, were in favour of donor anonymity. With regard to the
emotional development of the children, more emotional/behavioural problems
were revealed among DI children than among children who were naturally
conceived. No association was found between secrecy and the
emotional/behavioural adjustment of the children.
相似文献
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T E Medvedeva V K Kudriavtseva I V Zhikhareva V V Romashkina G I Aleksandrova A I Klimov 《Voprosy virusologii》1991,36(2):96-100
An analysis of ts-mutations in the genomes of native and cold-adapted variants of influenza A/Leningrad/134/57 (H2N2) virus based on the use of fowl plague virus ts mutants was carried out. The recombination test was done by the conventional method in chick embryo fibroblast culture (genes PB2, PB1, PA, NP, NA, M and NS) or cell systems permissive for reproduction of human influenza virus (gene HA). The cold-adapted strain A/Len/17 used for preparation of live influenza vaccine (LIV) for adults was shown to have 4 ts mutations: three in "internal" genes (PB2, NP, and M) and one in gene 4 coding for hemagglutinin (HA). The more attenuated cold-adapted donor A/Len/47 for preparation of similar LIV for children acquired three additional ts mutations: two (PB1 and NS) in "internal" genes and one in gene 6 coding for neuraminidase (NA). The accumulation of ts mutations in the genome of cold-adapter strains was found to be accompanied by a decrease in their pneumotropicity for mice as well as their detectability in different organs of these animals. 相似文献
8.
Recombinant cold-adapted attenuated influenza A vaccines for use in children: molecular genetic analysis of the cold-adapted donor and recombinants 下载免费PDF全文
Y Z Ghendon F I Polezhaev K V Lisovskaya T E Medvedeva G I Alexandrova A I Klimov 《Infection and immunity》1984,44(3):730-733
A previously described cold-adapted attenuated virus, A/Leningrad/134/17/57 (H2N2), was further modified by 30 additional passages in chicken embryos at 25 degrees C. This virus had a distinct temperature-sensitive (ts) phenotype, grew well in chicken embryos at 25 degrees C, and failed to recombine with reference ts mutants of fowl plague virus containing ts lesions in five genes coding for non-glycosylated proteins (genes 1, 2, 5, 7, and 8). Recombination of A/Leningrad/134/47/57 with wild-type influenza virus strains A/Leningrad/322/79 (H1N1) and A/Bangkok/1/79(H3N2) yielded ts recombinants 47/25/1(H1N1) and 47/7/2 (H3N2). These recombinants inherited their ts phenotype and ability to reproduce in chicken embryos at 25 degrees C from the cold-adapted parent. Analysis of the genome composition of the recombinants obtained by recombination of the cold-adapted donor with wild-type influenza virus strains A/Leningrad/322/79(H1N1) and A/Bangkok/1/79(H3N2) showed that recombinants 47/25/1(H1N1) and 47/7/2 (H3N2) inherited five and six genes, respectively, from the cold-adapted parent, and hemagglutinin and neuraminidase genes from the wild-type strains. 相似文献
9.
A comparative analysis of the antihaemagglutinating, virus-neutralizing and complement-fixing activities of 19 S, 7 S, 4S and 1.5 S fractions of blood sera from goats of different ages pastured in a tick-borne encephalitis focus was carried out. Changes in the immunological activity of different fractions in relation to the age of the animals are discussed. 相似文献
10.
Neuroprotective effect of epinephrine is revealed against the background of prazosin, β-antagonists and their combinations
protect against cerebral ischemia. α2-Antagonists (but not α1) block the neuroprotective effect of these combinations, methyldopa, guanabenz, clonidine, and oxymetazoline and decrease
brain resistance to ischemia. α2-Adrenoreceptors participate in the endogenic mechanism of brain resistance to ischemia and in the neuroprotective effect.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 10, pp. 413–416, October, 1997 相似文献