Ethical dilemmas in pharmacy.

Results of surveys in which pharmacy students and pharmacists responded to ethical dilemmas are discussed. Respondents indicated a high level of concern about patient welfare and patient rights in dilemmas involving conflicts with socio-economic issues, and with peers and physicians. Conflicts that might arise as the roles of pharmacists change and the health-care systems evolve are also discussed.     

Blood cell transplantation: past,present and future

Blood cell transplantation is rapidly replacing bone marrow transplantation for restoration of hematopoiesis after high-dose chemotherapy in both the autologous and allogeneic settings. Future developments of BCT will be discussed.     

The Effects of Early Childhood Abuse and the Development of Resiliency

Recently, the number of young children who have suffered from the traumas of abuse and neglect has increased. There are negative cognitive, neurological, and psychological effects from this maltreatment which is described in this article. Interventions which can prevent neglect and abuse and further resiliency in the young victims are discussed. As concerned individuals, we need to advocate for preventive and therapeutic efforts which promote resiliency in maltreated children.     

Can cancer be cured by meditation and "natural therapy"? A critical review of the book You can conquer cancer by Ian Gawler

There is a widespread belief that cancer is caused, at least in part, by aberrant mental processes. A corollary of this belief is that cancer may be cured by the application of the mind. These ideas are fostered in Australia by a popular book You can conquer cancer by Ian Gawler, a veterinary surgeon who attributes, at least in part, the development and subsequent cure of his own cancer to such processes. Critical examination of these beliefs finds evidence in their support to be lacking. None the less, many patients with cancer in this country follow the book's advice, often on the basis that it "at least can do no harm". While some patients may be aided to come to terms with their disease and to lead more fulfilling lives by taking up meditation and the positive approach to living that is described in the book, it also contains recommendations about orthodox treatments, life-style and diet which, if adopted uncritically, could be quite detrimental. The potentially harmful effects of accepting such unproved ideas about cancer need to be known more widely. Furthermore, because his ideas are making such an impact on the day-to-day treatment of cancer in this country, Gawler owes it to the community to justify, with evidence, his claims that by meditation patients with cancer may be enabled to achieve a cure of their disease in a way that is unattainable with orthodox medical treatment alone.     

乳腺管状小叶癌

乳腺管状小叶癌（Tubulolobular carcinoma，TLC）最初是被作为小叶癌的管状变型。作者总结了27例TLC的组织学、免疫表型和临床特征，并与纯小管癌和经典型小叶癌进行了比较。此组患者年龄43-79岁（中位年龄60岁）。1例双侧乳腺受累，5例病变为多灶性。肿瘤直径0．5-2．5cm，色灰褐，质硬。组织学观察：TLC的肿瘤细胞形成管状和条索状两种结构模式并相互混杂，且两者比例相当（统称为管状小叶模式）。     

Does Hemopoietic Stem Cell Transplantation Have a Role in Treatment of Severe Rheumatoid Arthritis?

Based on animal models and limited clinical experience, there is considerable interest in use of high-dose immunosuppression followed by hemopoietic stem cell transplantation as treatment for severe rheumatoid arthritis. Because of its relatively low treatment-related mortality and morbidity, autologous transplantation is a more attractive option than allogeneic transplantation for initial clinical trials, even though anecdotal reports suggest that allogeneic transplantation has a greater likelihood of bringing about long-term disease control. The approach remains experimental with many unanswered questions such as the value and safety of high-dose therapy without transplantation, the need for T cell purging, the possible deleterious effects of post-transplant hemopoietic growth factors and the potential of mini allogeneic transplantation (a process whereby intense immunosuppression is combined with less intense myelosuppression). To achieve quick progress it is essential that clinical trials be carefully designed with all cases being reported to the Autoimmune Disease Stem Cell Project Database.     

Absence of simian virus 40 (SV40) DNA in lymphoma samples from Tasmania, Australia

AIMS: It has been postulated that the recent world-wide increase in the incidence of non-Hodgkin's lymphoma (NHL) may have been caused by human infection with simian virus 40 (SV40) (a lymphotropic monkey virus that was introduced to man from contaminated poliovirus vaccines between 1955 and 1963); therefore, we set out to determine the incidence of SV40 DNA positivity in lymphoma samples from patients in Tasmania, Australia. METHODS: One hundred lymph node samples, 50 from patients with lymphomas and 50 from controls, were tested using PCR amplification of three SV40-specific primer pairs followed by dot-blot hybridisation. RESULTS: All of the samples tested contained amplifiable DNA, but none contained amplifiable SV40 sequences with any of the primer sets used. CONCLUSIONS: Our results demonstrate absence of SV40 in the lymphoid tissues of our study population in Tasmania, Australia. SV40 does not explain the increasing incidence of NHL in our population.